Platelet activating factor receptor antagonists improve the efficacy of experimental chemo- and radiotherapy [PDF]
Clinics, 2018 Platelet activating factor is a lipid mediator of inflammation, and in recent decades, it has emerged as an important factor in tumor outcomes. Platelet activating factor acts by specific binding to its receptor, which is present in both tumor cells and ...
Ildefonso Alves da Silva Junior +3 more
doaj +5 more sources
Systemic Chemotherapy Is Modulated by Platelet-Activating Factor-Receptor Agonists [PDF]
Mediators of Inflammation, 2015 Chemotherapy is used to treat numerous cancers including melanoma. However, its effectiveness in clinical settings is often hampered by various mechanisms.
Ravi P. Sahu +2 more
doaj +5 more sources
Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor [PDF]
Nature Communications, 2022 The functional consequence of G protein-coupled receptor oligomerization remains debated. Here the authors show that platelet-activating factor receptor oligomerization enhances G protein coupling, and restrains β-arrestin recruitment and internalization.
Junke Liu +11 more
doaj +2 more sources
Cells, 2021 The platelet-activating factor receptor (PAFR) and its ligand (PAF) are important inflammatory mediators that are overexpressed in ovarian cancer. The receptor is an important player in ovarian cancer development.
Eileen Deuster +14 more
doaj +3 more sources
Bovine Respiratory Syncytial Virus Enhances the Adherence of Pasteurella multocida to Bovine Lower Respiratory Tract Epithelial Cells by Upregulating the Platelet-Activating Factor Receptor [PDF]
Frontiers in Microbiology, 2020 Coinfection by bovine respiratory syncytial virus (BRSV) and Pasteurella multocida (PM) frequently has been observed in cattle that develop severe pneumonia.
Putu Eka Sudaryatma +13 more
doaj +2 more sources
A Possible Role for Platelet-Activating Factor Receptor in Amyotrophic Lateral Sclerosis Treatment [PDF]
Frontiers in Neurology, 2018 Amyotrophic lateral sclerosis (ALS) is the third most prevalent neurodegenerative disease affecting upper and lower motor neurons. An important pathway that may lead to motor neuron degeneration is neuroinflammation.
Marcelo R. S. Briones +6 more
doaj +2 more sources
Platelet-Activating Factor Receptor Ligands Protect Tumor Cells from Radiation-Induced Cell Death [PDF]
Frontiers in Oncology, 2018 Irradiation generates oxidized phospholipids that activate platelet-activating factor receptor (PAFR) associated with pro-tumorigenic effects. Here, we investigated the involvement of PAFR in tumor cell survival after irradiation. Cervical cancer samples
Ildefonso Alves da Silva-Junior +4 more
doaj +2 more sources
Upregulated pneumococcal adhesion molecule (platelet-activating factor receptor) may predispose COPD patients to community-acquired pneumonia [PDF]
International Journal of COPD, 2017 Shakti Dhar Shukla,1,2 Philip M Hansbro,1,2 Eugene Haydn Walters3 1School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, 2Hunter Medical Research Institute, New Lambton Heights, NSW, 3School of Medicine, University of ...
Shukla SD, Hansbro PM, Walters EH
doaj +2 more sources
Platelet-activating factor receptor (PAFR) regulates neuronal maturation and synaptic transmission during postnatal retinal development [PDF]
Frontiers in Cellular NeuroscienceIntroductionPlatelet-activating factor (PAF), PAF receptor (PAFR), and PAF- synthesis/degradation systems are involved in essential CNS processes such as neuroblast proliferation, differentiation, migration, and synaptic modulation.
Barbara Dalmaso +5 more
doaj +2 more sources
Targeting the Platelet-Activating Factor Receptor (PAF-R): Antithrombotic and Anti-Atherosclerotic Nutrients. [PDF]
Nutrients, 2022 Harishkumar R +5 more
europepmc +2 more sources