Platelet activating factor receptor antagonists improve the efficacy of experimental chemo- and radiotherapy. [PDF]
Clinics (Sao Paulo), 2018 Platelet activating factor is a lipid mediator of inflammation, and in recent decades, it has emerged as an important factor in tumor outcomes. Platelet activating factor acts by specific binding to its receptor, which is present in both tumor cells and ...
da Silva Junior IA +3 more
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Systemic chemotherapy is modulated by platelet-activating factor-receptor agonists. [PDF]
Mediators Inflamm, 2015 Chemotherapy is used to treat numerous cancers including melanoma. However, its effectiveness in clinical settings is often hampered by various mechanisms.
Sahu RP, Ferracini M, Travers JB.
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Platelet-Activating Factor-Receptor and Tumor Immunity. [PDF]
JSM Cell Dev Biol, 2014 First described in 1972 by Benveniste and colleagues, platelet-activating factor (PAF) remains one of the potent phospholipid known to date. The role of PAF produced enzymatically in mediating diverse biological and pathophysiological processes including
Sahu RP, Konger RL, Travers JB.
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Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor. [PDF]
Nat Commun, 2022 The functional consequence of G protein-coupled receptor oligomerization remains debated. Here the authors show that platelet-activating factor receptor oligomerization enhances G protein coupling, and restrains β-arrestin recruitment and internalization.
Liu J +11 more
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Macrophage Derived Platelet Activating Factor Implicated in the Resolution Phase of Gouty Inflammation [PDF]
International Journal of Inflammation, 2014 Human blood derived in vitro differentiated monocytes or macrophages are a population of cells which have been investigated over the years to determine the role these cells play in the resolution phase of gout.
Darshna Yagnik
doaj +3 more sources
Bovine Respiratory Syncytial Virus Enhances the Adherence of Pasteurella multocida to Bovine Lower Respiratory Tract Epithelial Cells by Upregulating the Platelet-Activating Factor Receptor. [PDF]
Front Microbiol, 2020 Coinfection by bovine respiratory syncytial virus (BRSV) and Pasteurella multocida (PM) frequently has been observed in cattle that develop severe pneumonia.
Sudaryatma PE +6 more
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A Possible Role for Platelet-Activating Factor Receptor in Amyotrophic Lateral Sclerosis Treatment. [PDF]
Front Neurol, 2018 Amyotrophic lateral sclerosis (ALS) is the third most prevalent neurodegenerative disease affecting upper and lower motor neurons. An important pathway that may lead to motor neuron degeneration is neuroinflammation.
Briones MRS +5 more
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Platelet-Activating Factor Receptor Ligands Protect Tumor Cells from Radiation-Induced Cell Death. [PDF]
Front Oncol, 2018 Irradiation generates oxidized phospholipids that activate platelet-activating factor receptor (PAFR) associated with pro-tumorigenic effects. Here, we investigated the involvement of PAFR in tumor cell survival after irradiation. Cervical cancer samples
da Silva-Junior IA +4 more
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Platelet-Activating Factor Disrupts the Nasal Epithelial Barrier Independently of the Platelet-Activating Factor Receptor Pathway. [PDF]
Allergy Asthma Immunol ResPlatelet-activating factor (PAF) mediates nasal congestion and rhinorrhea by affecting vascular permeability, but the underlying mechanisms remain unclear. Here, we sought to explore the effect of PAF on the nasal epithelial barrier in chronic rhinosinusitis with nasal polyps (CRSwNP).Human nasal epithelial cells (hNECs) were pre-treated with Apafant ...
Tan J +7 more
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Upregulated pneumococcal adhesion molecule (platelet-activating factor receptor) may predispose COPD patients to community-acquired pneumonia. [PDF]
Int J Chron Obstruct Pulmon Dis, 2017 Shakti Dhar Shukla,1,2 Philip M Hansbro,1,2 Eugene Haydn Walters3 1School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, 2Hunter Medical Research Institute, New Lambton Heights, NSW, 3School of Medicine, University of ...
Shukla SD, Hansbro PM, Walters EH.
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