Results 31 to 40 of about 5,437,630 (278)

Anaphylactic shock depends on endothelial Gq/G11 [PDF]

, 2009
Anaphylactic shock is a severe allergic reaction involving multiple organs including the bronchial and cardiovascular system. Most anaphylactic mediators, like platelet-activating factor (PAF), histamine, and others, act through G protein – coupled ...
Nina Wettschureck, Fleming, Ingrid, Schutz, G., Stefan Offermanns, Fleming, I., Angela Wirth, Habermehl, D., Günther Schütz, Offermanns, S., Fißlthaler, Beate, Wirth, A., Moers, Alexandra, Wettschureck, N., Moers, A., Korhonen, H., Habermehl, Daniel, Ingrid Fleming, Fisslthaler, B., Daniel Habermehl, Offermanns, Stefan, Thomas Wieland, Wieland, Thomas, Beate Fisslthaler, Wieland, T., Alexandra Moers, Korhonen, Hanna, Schütz, Günther, Wettschureck, Nina, Hanna Korhonen, Wirth, Angela   +29 more
core   +1 more source

Functions of PDGF-A and -C. Essential ligands for the PDGF alpha receptor [PDF]

, 1996
Altered protein kinase activity is a contributing factor in many diseases including most formsof human malignancies, and there is reason to believe that protein kinases will prove to be majordrug targets in the treatment of cancer.
Lindahl, Per, Hellström, Mats, Boström, Hans, Pekna, Marcela, Boström, Hans 1967-, Kurland, Siri, Hedstrand, Håkan, Gebre-Medhin, Samuel, Betsholtz, Christer, Nilsson, Mia, Törnell, Jan, Levéen, Per, Heath, John K, Willetts, Karen, Schalling, Martin, Pekny, Milos, Pekna, M, Hellstrom, M, Willetts, K, Schalling, M,, Leveen, P, Lindahl, P, GebreMedhin, S, Pekny, M, Hedstrand, H, Bostrom, H   +25 more
core   +1 more source

PAF enhances MMP-2 production in rat aortic VSMCs via a β-arrestin2-dependent ERK signaling pathway[S]

Journal of Lipid Research, 2013
Platelet-activating factor (PAF), 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine, is a potent phospholipid mediator and has been reported to be localized in atherosclerotic plaque.
Yun H. Kim, Seung J. Lee, Kyo W. Seo, Jin U. Bae, So Y. Park, Eun K. Kim, Sun S. Bae, Jae H. Kim, Chi D. Kim   +8 more
doaj   +1 more source

Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [PDF]

, 2006
Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases.
Wolfgang Siess, Siess, Wolfgang
core   +1 more source

Regulation of the receptor for platelet-activating factor on human platelets [PDF]

Biochemical Journal, 1993
Human platelets possess about 300 receptors for platelet-activating factor (PAF) per cell with a Kd of about 0.2 nM. In the present study we investigated whether these receptors are subject to intracellular control mechanisms. Preincubation with the protein kinase C inhibitor staurosporine had no effect, and also agents that increase cyclic AMP failed ...
J A, Burgers, J W, Akkerman
openaire   +2 more sources

Tricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns

Cell Reports, 2019
Summary: Increased glycolysis parallels immune cell activation, but the role of pyruvate remains largely unexplored. We found that stimulation of dendritic cells with the fungal surrogate zymosan causes decreases of pyruvate, citrate, itaconate, and α ...
Saioa Márquez, José Javier Fernández, Cristina Mancebo, Carmen Herrero-Sánchez, Sara Alonso, Tito A. Sandoval, Macarena Rodríguez Prados, Juan R. Cubillos-Ruiz, Olimpio Montero, Nieves Fernández, Mariano Sánchez Crespo   +10 more
doaj   +1 more source

Plasmin Inhibitors Prevent Leukocyte Accumulation and Remodeling Events in the Postischemic Microvasculature [PDF]

, 2011
Clinical trials revealed beneficial effects of the broad-spectrum serine protease inhibitor aprotinin on the prevention of ischemia-reperfusion (I/R) injury. The underlying mechanisms remained largely unclear.
Nina Berberich, Rehberg, Markus, Wymann, Matthias P., Wymann, M. P., Uhl, B., Lerchenberger, Max, Uhl, Bernd, Berberich, Nina, Reichel, Christoph A., Bernd Uhl, Markus Rehberg, Matthias P. Wymann, Zahler, Stefan, Reichel, C. A., Uhl Bernd, Berberich Nina, Krombach Fritz, Lerchenberger, M., Stefan Zahler, Reichel Christoph A., Berberich, N., Fritz Krombach, Rehberg Markus, Zahler, S., Christoph A. Reichel, Krombach, Fritz, Max Lerchenberger, Krombach, F., Lerchenberger Max, Zahler Stefan, Matthias P Wymann, Rehberg, M., Christoph A Reichel, Wymann Matthias P.   +33 more
core   +1 more source

Platelet-activating factor receptor in GtoPdb v.2023.1 [PDF]

, 2023
Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is an ether phospholipid mediator associated with platelet coagulation, but also subserves inflammatory roles.
Whittaker, Mark, Oliveira Rios, Francisco Jose, Rebecca Hills, O\u27Neill, Chris, Ishii, Satoshi, Ninio, Ewa, Francisco Jose Oliveira Rios, Jeffery B. Travers, Travers, Jeffery B., Mark Whittaker, Chris O'Neill, Satoshi Ishii, Thomas McIntyre, Ewa Ninio, Hills, Rebecca, Jancar, Sonia, McIntyre, Thomas, Sonia Jancar   +17 more
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Data showing effects of a PI3K-δ inhibitor on neutrophil superoxide production during FPR2 activation and reactivation

Data in Brief, 2020
Reactive oxygen species (ROS) generated by the NADPH oxidase are crucial for antimicrobial host defense and also play a role in the regulation of inflammatory processes.
André Holdfeldt, Martina Sundqvist, Claes Dahlgren, Huamei Forsman   +3 more
doaj   +1 more source

Macrophage Derived Platelet Activating Factor Implicated in the Resolution Phase of Gouty Inflammation

International Journal of Inflammation, 2014
Human blood derived in vitro differentiated monocytes or macrophages are a population of cells which have been investigated over the years to determine the role these cells play in the resolution phase of gout.
Darshna Yagnik
doaj   +1 more source