Results 31 to 40 of about 158,362 (293)

Platelets at the vascular interface [PDF]

, 2018
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Bergmeier, Wolfgang, Stefanini, Lucia
core   +1 more source

Potentiation of thrombus instability: a contributory mechanism to the effectiveness of antithrombotic medications [PDF]

, 2018
© The Author(s) 2018The stability of an arterial thrombus, determined by its structure and ability to resist endogenous fibrinolysis, is a major determinant of the extent of infarction that results from coronary or cerebrovascular thrombosis.
A Gast, AD Michelson, B Labarthe, B Shen, C Patrono, CT Ammollo, D Capodanno, D Gailani, DA Gorog, Diana A. Gorog, DM Coenen, E Álvarez, ER Bates, F Kabirian, F Müller, F Semeraro, G Stephens, H Brogren, HE Speich, HE Speich, HJ Weiss, HJ Weiss, HR Baumgartner, J Zilberman-Rudenko, JD McFadyen, JI Weitz, JM Cosemans, JP Collet, JP Collet, K Hosokawa, K Nagatsuka, KS Sakariassen, L Valerio, LF Brass, M Cattaneo, M Farag, M Humbert, M Larsson, M Li, M Ungerer, MA Bailey, MI Furman, MJ Price, ML Montfoort von, MS Sabatine, P Andre, P Seizer, PA Borne von dem, PP Wadowski, R Hellmuth, R Nergiz-Unal, RA Ajjan, S Goto, S Goto, SA Shaya, SB Larsen, SJ Marciniak, T Heitzer, T Renné, VT Turitto, VT Turitto, WA Schumacher, WS Nesbitt, X Wang, Y Yano, YC Lau, ZM Ruggeri   +66 more
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Tricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns

Cell Reports, 2019
Summary: Increased glycolysis parallels immune cell activation, but the role of pyruvate remains largely unexplored. We found that stimulation of dendritic cells with the fungal surrogate zymosan causes decreases of pyruvate, citrate, itaconate, and α ...
Saioa Márquez, José Javier Fernández, Cristina Mancebo, Carmen Herrero-Sánchez, Sara Alonso, Tito A. Sandoval, Macarena Rodríguez Prados, Juan R. Cubillos-Ruiz, Olimpio Montero, Nieves Fernández, Mariano Sánchez Crespo   +10 more
doaj   +1 more source

Data showing effects of a PI3K-δ inhibitor on neutrophil superoxide production during FPR2 activation and reactivation

Data in Brief, 2020
Reactive oxygen species (ROS) generated by the NADPH oxidase are crucial for antimicrobial host defense and also play a role in the regulation of inflammatory processes.
André Holdfeldt, Martina Sundqvist, Claes Dahlgren, Huamei Forsman   +3 more
doaj   +1 more source

Platelets and galectins [PDF]

, 2014
A major function of platelets is keeping the vascular system intact. Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug.
Schattner, Mirta Ana
core   +1 more source

Potential mechanisms involved on how systemic IgG antibodies specific to vascular endothelial growth factor (VEGF) and induced by active immunotherapy decrease platelet derived free-VEGF

Platelets, 2022
CIGB-247 is a vascular endothelial growth factor (VEGF)-based active immunotherapy and it is currently under investigation for cancer treatment. This specific active immunotherapy encompasses two vaccine candidates that use a human VEGF variant molecule ...
Javier Sánchez Ramírez, Yanelys Morera Díaz, Mónica Bequet-Romero, Marta Ayala Ávila   +3 more
doaj   +1 more source

Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. [PDF]

, 2020
Alcoholic liver disease (ALD) is a leading cause of cirrhosis in the United States, which is characterized by extensive deposition of extracellular matrix proteins and formation of a fibrous scar.
Baglieri, Jacopo, Benner, Chris, Brenner, David, Chen, Yibu, Diggle, Karin, Dorko, Ken, Hosseini, Mojgan, Kisseleva, Tatiana, Lam, Kevin, Liu, Xiao, Meshgin, Nairika, Musallam, Sami G, Pan, Stephanie Q, Presnell, Sharon, Rosenthal, Sara Brin, Tsukamoto, Hidekazu, Wu, Raymond   +16 more
core   +1 more source

A Study of the PDGF Signaling Pathway with PRISM [PDF]

, 2011
In this paper, we apply the probabilistic model checker PRISM to the analysis of a biological system -- the Platelet-Derived Growth Factor (PDGF) signaling pathway, demonstrating in detail how this pathway can be analyzed in PRISM.
A. Aziz, A. Gutiérrez-Uzquiza, A. L. Reddi, A. Regev, A. Sadot, C. A. Joazeiro, C. E. Bazenet, C.-H. Heldin, D. Hanahan, E. M. Hahn, Erik de Vink, F. Ciocchetta, G. Krauss, Ion Petre, J. Cools, J. Fisher, J. Fisher, J. Heath, J. Krivine, J. Yu, J. Yu, Jun Pang, K. Anan, K. Yokote, M. Miettinen, M. Schwarick, M. Tallquist, M. Z. Kwiatkowska, M. Z. Kwiatkowska, M. Z. Kwiatkowska, M. Z. Kwiatkowska, Monique Wiesinger, N. Bonzanni, N. Bonzanni, P. Drábik, Panuwat Trairatphisan, Qixia Yuan, S. Hart, S. K. Jha, S. Valgeirsdóttir, Sjouke Mauw, T. Han, T. R. Golub, Thomas Sauter, U.S. Bhalla   +44 more
core   +3 more sources

Human platelets and their capacity of binding viruses: Meaning and challenges? [PDF]

, 2015
Blood platelets are first aimed at ensuring primary hemostasis. Beyond this role, they have been acknowledged as having functions in the maintenance of the vascular arborescence and, more recently, as being also innate immune cells, devoted notably to ...
Chabert, Adrien, Cognasse, Fabrice, Garraud, Olivier, Gomez, Ricardo Martin, Hamzeh Cognasse, Hind, Pozzetto, Bruno, Schattner, Mirta Ana   +6 more
core   +2 more sources

Paradigm of biased PAR1 (protease-activated receptor-1) activation and inhibition in endothelial cells dissected by phosphoproteomics [PDF]

, 2017
Thrombin is the key serine protease of the coagulation cascade and mediates cellular responses by activation of PARs (protease-activated receptors). The predominant thrombin receptor is PAR1, and in endothelial cells (ECs), thrombin dynamically regulates
Hoogendijk, Arie J., Meijer, Alexander B., Mertens, Koen, Simpson, Pelle J., van Alphen, Floris P.J., van den Biggelaar, Maartje, van den Eshof, Bart L., Zanivan, Sara   +7 more
core   +2 more sources