Results 11 to 20 of about 5,437,630 (278)

Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat [PDF]

Journal of Occupational Medicine and Toxicology, 2008
Background Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
Groneberg David A, Staats Petra, Schmidt Rene, Wagner Ulrich   +3 more
doaj   +2 more sources

Airway epithelial platelet-activating factor receptor expression is markedly upregulated in chronic obstructive pulmonary disease

International Journal of COPD, 2014
Shakti Dhar Shukla,1,* Sukhwinder Singh Sohal,1,* Malik Quasir Mahmood,1 David Reid,2 Hans Konrad Muller,1 Eugene Haydn Walters1 1NHMRC Centre for Research Excellence for Chronic Respiratory Disease and Lung Ageing, School of Medicine, University of ...
Shukla SD, Sohal SS, Mahmood MQ, Reid D, Muller HK, Walters EH   +5 more
doaj   +2 more sources

An antagonist of the platelet-activating factor receptor inhibits adherence of both nontypeable Haemophilus influenzae and Streptococcus pneumoniae to cultured human bronchial epithelial cells exposed to cigarette smoke

International Journal of COPD, 2016
Shakti D Shukla,1,* Rory L Fairbairn,1,* David A Gell,1 Roger D Latham,1 Sukhwinder S Sohal,1,2 Eugene H Walters,1 Ronan F O’Toole11Breathe Well Centre, School of Medicine, Faculty of Health, University of Tasmania, Hobart, TAS, Australia; 2School ...
Shukla SD, Fairbairn RL, Gell DA, Latham RD, Sohal SS, Walters EH, O’Toole RF   +6 more
doaj   +1 more source

Receptor‐independent metabolism of platelet‐activating factor by myelogenous cells [PDF]

FEBS Letters, 1989
Human neutrophils incorporate and metabolize platelet‐activating factor (PAF). We dissociated these events from PAF binding to its receptors. Cells were pretreated with either pronase, a PAF antagonist (L652731), or excess PAF. This reduced PAF receptor numbers by 70 to almost 100% but had no comparable effect upon the neutrophil's ability to ...
O'Flaherty, Joseph T., Chabot, Marie C., Redman, Jimmy, Jacobson, David, Wykle, Robert L.   +4 more
openaire   +4 more sources

The effect of PAFR on cisplatin sensitivity in ovarian cancer cells and its mechanism [PDF]

Zhongguo aizheng zazhi, 2021
Background and purpose: The current treatment of ovarian cancer is surgery and adjuvant platinum-based chemotherapy. However, relapse and drug resistance are common.
俞　弋, 丛　青, 徐丛剑, 姜　伟   +3 more
doaj   +2 more sources

UVB-Induced Microvesicle Particle Release and Its Effects on the Cutaneous Microenvironment

Frontiers in Immunology, 2022
Ultraviolet B radiation (UVB) has profound effects on human skin that results in a broad spectrum of immunological local and systemic responses and is the major cause of skin carcinogenesis.
Timothy C. Frommeyer, Michael M. Gilbert, Garrett V. Brittain, Tongfan Wu, Trang Q. Nguyen, Craig A. Rohan, Craig A. Rohan, Craig A. Rohan, Jeffrey B. Travers, Jeffrey B. Travers, Jeffrey B. Travers   +10 more
doaj   +1 more source

Lipolysis generates platelet dysfunction after in vivo heparin administration [PDF]

, 2002
Heparin, when administered to patients undergoing operations using cardiopulmonary bypass, induces plasma changes that gradually impair platelet macroaggregation, but heparinization of whole blood in vitro does not have this effect.
Day, S., Chaudhry, M.A., Muriithi, E.W., Belcher, P.R.   +3 more
core   +8 more sources

Platelet-Activating Factor Disrupts the Nasal Epithelial Barrier Independently of the Platelet-Activating Factor Receptor Pathway. [PDF]

Allergy Asthma Immunol Res
Platelet-activating factor (PAF) mediates nasal congestion and rhinorrhea by affecting vascular permeability, but the underlying mechanisms remain unclear. Here, we sought to explore the effect of PAF on the nasal epithelial barrier in chronic rhinosinusitis with nasal polyps (CRSwNP).Human nasal epithelial cells (hNECs) were pre-treated with Apafant ...
Tan J, Han X, Li S, Wang Q, Zhao L, Li Y, Duan S, Zhang L.   +7 more
europepmc   +3 more sources

Interplay Between EGFR and the Platelet-Activating Factor/PAF Receptor Signaling Axis Mediates Aggressive Behavior of Cervical Cancer

Frontiers in Oncology, 2020
Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase widely expressed in cervical tumors, being correlated with adverse clinical outcomes. EGFR may be activated by a diversity of mechanisms, including transactivation by G-protein coupled
Juliana L. Souza, Karina Martins-Cardoso, Isabella S. Guimarães, Andréia C. de Melo, Angela H. Lopes, Robson Q. Monteiro, Vitor H. Almeida   +6 more
doaj   +1 more source

Platelet-activating factor: receptors and signal transduction [PDF]

Biochemical Journal, 1993
During the past two decades, studies describing the chemistry and biology of PAF have been extensive. This potent phosphoacylglycerol exhibits a wide variety of physiological and pathophysiological effects in various cells and tissues. PAF acts, through specific receptors and a variety of signal transduction systems, to elicit diverse biochemical ...
W, Chao, M S, Olson
openaire   +2 more sources