Results 11 to 20 of about 105,169 (258)

Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat

Journal of Occupational Medicine and Toxicology, 2008
Background Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
Groneberg David A, Staats Petra, Schmidt Rene, Wagner Ulrich   +3 more
doaj   +1 more source

Platelet-activating factor acetyl hydrolase IB2 dysregulated cell proliferation in ovarian cancer

Cancer Cell International, 2021
Background Ovarian cancer is the leading cause of death from gynaecologic illnessed worldwide. Platelet-activating factor acetyl hydrolase IB2 (PAF-AH IB2) is an intracellular serine esterase that hydrolyzes platelet-activating factor, a G-protein-like ...
YingYing He, Zhicheng He, Xiaoyu Zhang, Shubai Liu   +3 more
doaj   +1 more source

To hydrolyze or not to hydrolyze: the dilemma of platelet-activating factor acetylhydrolase

Journal of Lipid Research, 2014
Mounting ambiguity persists around the functional role of the plasma form of platelet-activating factor acetylhydrolase (PAF-AH). Because PAF-AH hydrolyzes PAF and related oxidized phospholipids, it is widely accepted as an anti-inflammatory enzyme.
Gopal Kedihitlu Marathe, Chaitanya Pandit, Chikkamenahalli Lakshminarayana Lakshmikanth, Vyala Hanumanthareddy Chaithra, Shancy Petsel Jacob, Cletus Joseph Michael D'Souza   +5 more
doaj   +1 more source

Platelet activating factor revisited [PDF]

Thorax, 1997
8A2 and acetyltransferase on membrane alkylacyl phospholipids. PAF was found to possess many properties that made it well suited as a proinflammatory mediator of inflammation in many inflammatory diseases. 1 Interest in Degradation of PAF its potential role as a mediator of asthma was fuelled Being a potent bioactive mediator, it makes sense that PAF ...
openaire   +2 more sources

Plasma PAF-acetylhydrolase in patients with coronary artery disease: results of a cross-sectional analysis

Journal of Lipid Research, 2003
Inflammation underlies both onset and perpetuation of atherosclerosis. Plasma lipoproteins transport the platelet-activating factor-acetylhydrolase (PAF-AH) with potentially anti-inflammatory activities.
Stefan Blankenberg, Dominique Stengel, Hans J. Rupprecht, Christoph Bickel, Ju¨rgen Meyer, François Cambien, Laurence Tiret, Ewa Ninio   +7 more
doaj   +1 more source

Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture

Reproductive Biology and Endocrinology, 2004
Background Platelet-activating factor and nitric oxide may be involved in the initiation of human labour as inflammatory mediators. The aim of this study was to test whether platelet-activating factor and lipopolysaccharide were able to induce nitric ...
Seyffarth Gunter, Nelson Paul N, Dunmore Simon J, Rodrigo Nalinda, Murphy Damian J, Carson Ray J   +5 more
doaj   +1 more source

Novel molecular analogues of phosphatidylcholines in a lipid extract from bovine brain: 1-long-chain acyl-2-short-chain acyl-sn-glycero-3-phosphocholines.

Journal of Lipid Research, 1989
A vasodepressor phospholipid fraction named Depressor-IA from a bovine brain lipid extract was analyzed by capillary gas-liquid chromatography-mass spectrometry as tert-butyldimethylsilyl derivatives after hydrolysis with phospholipase C.
A Tokumura, K Takauchi, T Asai, K Kamiyasu, T Ogawa, H Tsukatani   +5 more
doaj   +1 more source

Production of platelet-activating factor by washed rabbit platelets

Journal of Lipid Research, 1985
Production of platelet-activating factor by washed rabbit platelets under stimulation with the ionophore A23187 was investigated utilizing two groups of platelet preparations.
M Oda, K Satouchi, K Yasunaga, K Saito
doaj   +1 more source

Production of platelet-activating factor in slugs.

Journal of Lipid Research, 1991
The land slug, Incilaria bilineata, was shown to contain a large amount of 1-O-alkyl-2-acyl (long chain)-sn-glycero-3-phosphocholine, which accounts for as much as 47% of the choline glycerophospholipid fraction. Since this unique either phospholipid has
T Sugiura, T Ojima, T Fukuda, K Satouchi, K Saito, K Waku   +5 more
doaj   +1 more source

Platelet aggregometry assay for evaluating the effects of platelet agonists and antiplatelet compounds on platelet function in vitro

MethodsX, 2019
Platelet aggregometry assays are generally used for the analysis of platelet function but can also be adapted for further research and therapy focused applications.
Alexandros Tsoupras, Ioannis Zabetakis, Ronan Lordan   +2 more
doaj   +1 more source