Results 11 to 20 of about 1,055,543 (397)

Macrophage Derived Platelet Activating Factor Implicated in the Resolution Phase of Gouty Inflammation [PDF]

International Journal of Inflammation, 2014
Human blood derived in vitro differentiated monocytes or macrophages are a population of cells which have been investigated over the years to determine the role these cells play in the resolution phase of gout.
Darshna Yagnik
doaj   +3 more sources

Radiation therapy generates platelet-activating factor agonists [PDF]

, 2016
Pro-oxidative stressors can suppress host immunity due to their ability to generate oxidized lipid agonists of the platelet-activating factor-receptor (PAF-R).
Chin-Sinex, Helen Jan, Dynlacht, Joseph R., Garrett, Joy Elizabeth, Harrison, Kathleen A., Johnston II., Michael Edward, Konger, Raymond L., Li, Gengxin, McMullen, Kevin, Mendonca, Marc, Murphy, Robert C., Sahu, Ravi P., Spandau, Dan F., Travers, Jeffrey B., Weyerbacher, Jonathan   +13 more
core   +5 more sources

Anti–platelet factor 4 antibodies causing VITT do not cross-react with SARS-CoV-2 spike protein

Blood, 2021
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe adverse effect of ChAdOx1 nCoV-19 COVID-19 vaccine (Vaxzevria) and COVID-19 vaccine Janssen (Ad26.COV2.S), and associated with unusual thrombosis.
A. Greinacher, K. Selleng, J. Mayerle, R. Palankar, J. Wesche, S. Reiche, A. Aebischer, T. Warkentin, M. Muenchhoff, J. Hellmuth, O. Keppler, D. Duerschmied, A. Lother, S. Rieg, M. Gawaz, K. Mueller, C. Scheer, M. Napp, K. Hahnenkamp, G. Lucchese, A. Vogelgesang, A. Floeel, P. Lovreglio, Angela Stufano, R. Marschalek, T. Thiele   +25 more
semanticscholar   +1 more source

Factor V activity of platelets: evidence for an activated factor V molecule and for a platelet activator [PDF]

Blood, 1977
Abstract This study was prompted by the observation that fresh platelet suspensions--prepared by gel filtration or albumin density gradient centrifugation--possessed only minimal factor V activity, whereas frozen-and-thawed platelet suspensions possessed striking factor V activity.
Samuel I. Rapaport, Samuel I. Rapaport, Kathrine K. Lavine, Kathrine K. Lavine, Bjarne Østerud, Bjarne Østerud   +5 more
openaire   +4 more sources

Increased platelet activating factor levels in chronic spontaneous urticaria predicts refractoriness to antihistamine treatment: an observational study

Clinical and Translational Allergy, 2019
Background Platelet activating factor (PAF) is an endogenous, active phospholipid released from inflammatory cells, platelets, and endothelial cells, and is involved in the regulation of immune responses. Degradation of PAF by PAF acetylhydrolase (PAF-AH)
Bastsetseg Ulambayar, Eun-Mi Yang, Hyun-Young Cha, Yoo-Seob Shin, Hae-Sim Park, Young-Min Ye   +5 more
doaj   +1 more source

Forty Years Since the Structural Elucidation of Platelet-Activating Factor (PAF): Historical, Current, and Future Research Perspectives

Molecules, 2019
In the late 1960s, Barbaro and Zvaifler described a substance that caused antigen induced histamine release from rabbit platelets producing antibodies in passive cutaneous anaphylaxis.
R. Lordan, A. Tsoupras, I. Zabetakis, C. Demopoulos   +3 more
semanticscholar   +1 more source

Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase

Memorias do Instituto Oswaldo Cruz, 2005
Platelet-activating factor (PAF) is one of the most potent lipid mediators involved in inflammatory events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity.
Hugo C Castro Faria Neto, Diana M Stafforini, Stephen M Prescott, Guy A Zimmerman   +3 more
doaj   +1 more source

A Review of Platelet-Activating Factor As a Potential Contributor to Morbidity and Mortality Associated with Severe COVID-19

Clinical and Applied Thrombosis/Hemostasis, 2021
The precise mechanisms of pathology in severe COVID-19 remains elusive. Current evidence suggests that inflammatory mediators are responsible for the manifestation of clinical symptoms that precedes a fatal response to infection. This review examines the
Mark Klein MD, Vinh Dao PharmD, BCPS, Fatima Khan MD, MPH   +2 more
doaj   +1 more source

Platelet activating factor receptor antagonists improve the efficacy of experimental chemo- and radiotherapy

Clinics, 2018
Platelet activating factor is a lipid mediator of inflammation, and in recent decades, it has emerged as an important factor in tumor outcomes. Platelet activating factor acts by specific binding to its receptor, which is present in both tumor cells and ...
Ildefonso Alves da Silva Junior, Luciana Nogueira de Sousa Andrade, Sonia Jancar, Roger Chammas   +3 more
doaj   +1 more source

Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat

Journal of Occupational Medicine and Toxicology, 2008
Background Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
Groneberg David A, Staats Petra, Schmidt Rene, Wagner Ulrich   +3 more
doaj   +1 more source