Results 11 to 20 of about 1,044,846 (392)

Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat [PDF]

open access: yesJournal of Occupational Medicine and Toxicology, 2008
Background Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
Groneberg David A   +3 more
doaj   +5 more sources

To hydrolyze or not to hydrolyze: the dilemma of platelet-activating factor acetylhydrolase

open access: yesJournal of Lipid Research, 2014
Mounting ambiguity persists around the functional role of the plasma form of platelet-activating factor acetylhydrolase (PAF-AH). Because PAF-AH hydrolyzes PAF and related oxidized phospholipids, it is widely accepted as an anti-inflammatory enzyme.
Gopal Kedihitlu Marathe   +5 more
doaj   +2 more sources

Macrophage Derived Platelet Activating Factor Implicated in the Resolution Phase of Gouty Inflammation [PDF]

open access: yesInternational Journal of Inflammation, 2014
Human blood derived in vitro differentiated monocytes or macrophages are a population of cells which have been investigated over the years to determine the role these cells play in the resolution phase of gout.
Darshna Yagnik
doaj   +3 more sources

Impact of targeting the platelet-activating factor and its receptor in cancer treatment. [PDF]

open access: yesMil Med Res
The lipid mediator platelet-activating factor (PAF) and its receptor (PAFR) signaling play critical roles in a wide range of physiological and pathophysiological conditions, including cancer growth and metastasis.
Qaderi K   +3 more
europepmc   +2 more sources

Platelet activating factor in allergies

open access: yesInternational Journal of Immunopathology and Pharmacology, 2015
The platelet-activating factor (PAF) produced and released by mast cells, basophils, neutrophils, eosinophils, fibroblasts, platelets, endothelial cells, and even cardiac muscle cells plays an important role in inflammatory and thrombotic diseases. PAF has been shown to be an important mediator in anaphylaxis. Serum level of the factor correlates with
Zbigniew Bartuzi, Krzysztof Pałgan
openaire   +4 more sources

Platelet-activating Factor

open access: yesJapanese Journal of Thrombosis and Hemostasis, 1991
血 小 板 活 性 化 因 子(platelet-activating factor, PAF)は,現 在 の と こ ろ唯 一 非 常 に 強 力 な 生 理 活 性 を持 つ リン脂 質 で あ り,そ の 本 体 は ア ル キ ル エ ー テ ル 型 コ リ ン リ ン脂 質(1-0-alkyl2-acetyl-sn-glycero-3-phosphocholine, alkylacetyl-GPCho)で あ る(Fig.1).そ の 特 異 的 な構 造 の 一 つ で あ る ア ル キ ...
Jun-ichi Kambayashi, Tomio Kawasaki
openaire   +4 more sources

Platelet-activating factor acetyl hydrolase IB2 dysregulated cell proliferation in ovarian cancer. [PDF]

open access: yesCancer Cell Int, 2021
Background Ovarian cancer is the leading cause of death from gynaecologic illnessed worldwide. Platelet-activating factor acetyl hydrolase IB2 (PAF-AH IB2) is an intracellular serine esterase that hydrolyzes platelet-activating factor, a G-protein-like ...
He Y, He Z, Zhang X, Liu S.
europepmc   +2 more sources

PAF Physiology in Target Organ Systems—A Deep Dive to Understand the PAF Mystery in Pathogenesis of Disease

open access: yesHearts, 2021
The purpose of this literature review is to gain an overview of the role of platelet-activating factor (PAF) within each of the body systems and how it contributes to normal and pathophysiological states.
Nilank Shah, Karan Kumar, Nikeith Shah
doaj   +1 more source

The Platelet-Activating Factor Receptor’s Association with the Outcome of Ovarian Cancer Patients and Its Experimental Inhibition by Rupatadine

open access: yesCells, 2021
The platelet-activating factor receptor (PAFR) and its ligand (PAF) are important inflammatory mediators that are overexpressed in ovarian cancer. The receptor is an important player in ovarian cancer development.
Eileen Deuster   +14 more
doaj   +1 more source

UVB-Induced Microvesicle Particle Release and Its Effects on the Cutaneous Microenvironment

open access: yesFrontiers in Immunology, 2022
Ultraviolet B radiation (UVB) has profound effects on human skin that results in a broad spectrum of immunological local and systemic responses and is the major cause of skin carcinogenesis.
Timothy C. Frommeyer   +10 more
doaj   +1 more source

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