Results 21 to 30 of about 1,166,887 (302)

Increased platelet activating factor levels in chronic spontaneous urticaria predicts refractoriness to antihistamine treatment: an observational study

Clinical and Translational Allergy, 2019
Background Platelet activating factor (PAF) is an endogenous, active phospholipid released from inflammatory cells, platelets, and endothelial cells, and is involved in the regulation of immune responses. Degradation of PAF by PAF acetylhydrolase (PAF-AH)
Bastsetseg Ulambayar, Eun-Mi Yang, Hyun-Young Cha, Yoo-Seob Shin, Hae-Sim Park, Young-Min Ye   +5 more
doaj   +1 more source

Forty Years Since the Structural Elucidation of Platelet-Activating Factor (PAF): Historical, Current, and Future Research Perspectives

Molecules, 2019
In the late 1960s, Barbaro and Zvaifler described a substance that caused antigen induced histamine release from rabbit platelets producing antibodies in passive cutaneous anaphylaxis.
R. Lordan, A. Tsoupras, I. Zabetakis, C. Demopoulos   +3 more
semanticscholar   +1 more source

Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase

Memorias do Instituto Oswaldo Cruz, 2005
Platelet-activating factor (PAF) is one of the most potent lipid mediators involved in inflammatory events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity.
Hugo C Castro Faria Neto, Diana M Stafforini, Stephen M Prescott, Guy A Zimmerman   +3 more
doaj   +1 more source

Platelet activating factor receptor antagonists improve the efficacy of experimental chemo- and radiotherapy

Clinics, 2018
Platelet activating factor is a lipid mediator of inflammation, and in recent decades, it has emerged as an important factor in tumor outcomes. Platelet activating factor acts by specific binding to its receptor, which is present in both tumor cells and ...
Ildefonso Alves da Silva Junior, Luciana Nogueira de Sousa Andrade, Sonia Jancar, Roger Chammas   +3 more
doaj   +1 more source

A Review of Platelet-Activating Factor As a Potential Contributor to Morbidity and Mortality Associated with Severe COVID-19

Clinical and Applied Thrombosis/Hemostasis, 2021
The precise mechanisms of pathology in severe COVID-19 remains elusive. Current evidence suggests that inflammatory mediators are responsible for the manifestation of clinical symptoms that precedes a fatal response to infection. This review examines the
Mark Klein MD, Vinh Dao PharmD, BCPS, Fatima Khan MD, MPH   +2 more
doaj   +1 more source

Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat

Journal of Occupational Medicine and Toxicology, 2008
Background Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
Groneberg David A, Staats Petra, Schmidt Rene, Wagner Ulrich   +3 more
doaj   +1 more source

Platelet-activating factor acetyl hydrolase IB2 dysregulated cell proliferation in ovarian cancer

Cancer Cell International, 2021
Background Ovarian cancer is the leading cause of death from gynaecologic illnessed worldwide. Platelet-activating factor acetyl hydrolase IB2 (PAF-AH IB2) is an intracellular serine esterase that hydrolyzes platelet-activating factor, a G-protein-like ...
YingYing He, Zhicheng He, Xiaoyu Zhang, Shubai Liu   +3 more
doaj   +1 more source

Plasma PAF-acetylhydrolase in patients with coronary artery disease: results of a cross-sectional analysis

Journal of Lipid Research, 2003
Inflammation underlies both onset and perpetuation of atherosclerosis. Plasma lipoproteins transport the platelet-activating factor-acetylhydrolase (PAF-AH) with potentially anti-inflammatory activities.
Stefan Blankenberg, Dominique Stengel, Hans J. Rupprecht, Christoph Bickel, Ju¨rgen Meyer, François Cambien, Laurence Tiret, Ewa Ninio   +7 more
doaj   +1 more source

Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture

Reproductive Biology and Endocrinology, 2004
Background Platelet-activating factor and nitric oxide may be involved in the initiation of human labour as inflammatory mediators. The aim of this study was to test whether platelet-activating factor and lipopolysaccharide were able to induce nitric ...
Seyffarth Gunter, Nelson Paul N, Dunmore Simon J, Rodrigo Nalinda, Murphy Damian J, Carson Ray J   +5 more
doaj   +1 more source

Opposing Effects of Platelet-Activating Factor and Lyso-Platelet-Activating Factor on Neutrophil and Platelet Activation

Molecular Pharmacology, 2009
Platelet-activating factor (PAF) is a potent, bioactive phospholipid that acts on multiple cells and tissues through its G protein-coupled receptor (GPCR). PAF is not stored but is rapidly generated via enzymatic acetylation of the precursor 1-O-hexadecyl-2-hydroxy-sn-glycero-3-phosphocholine (lysoPAF). The bioactivity of PAF is effectively and tightly
Emily J, Welch, Ram P, Naikawadi, Zhenyu, Li, Phoebe, Lin, Satoshi, Ishii, Takao, Shimizu, Chinnaswamy, Tiruppathi, Xiaoping, Du, Papasani V, Subbaiah, Richard D, Ye   +9 more
openaire   +3 more sources