Results 11 to 20 of about 115,616 (306)

Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat [PDF]

Journal of Occupational Medicine and Toxicology, 2008
Background Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
Groneberg David A, Staats Petra, Schmidt Rene, Wagner Ulrich   +3 more
doaj   +2 more sources

Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture [PDF]

Reproductive Biology and Endocrinology, 2004
Background Platelet-activating factor and nitric oxide may be involved in the initiation of human labour as inflammatory mediators. The aim of this study was to test whether platelet-activating factor and lipopolysaccharide were able to induce nitric ...
Seyffarth Gunter, Nelson Paul N, Dunmore Simon J, Rodrigo Nalinda, Murphy Damian J, Carson Ray J   +5 more
doaj   +2 more sources

Platelet activating factor receptor antagonists improve the efficacy of experimental chemo- and radiotherapy

Clinics, 2018
Platelet activating factor is a lipid mediator of inflammation, and in recent decades, it has emerged as an important factor in tumor outcomes. Platelet activating factor acts by specific binding to its receptor, which is present in both tumor cells and ...
Ildefonso Alves da Silva Junior, Luciana Nogueira de Sousa Andrade, Sonia Jancar, Roger Chammas   +3 more
doaj   +2 more sources

Impact of prostaglandin glaucoma drops on platelet-activating factor action: an in vitro study

Drug Design, Development and Therapy, 2016
Marilita M Moschos,1 Eirini Nitoda,1 Irini P Chatziralli,1 Georgios D Panos,2 Constantinos A Demopoulos3 11st Department of Ophthalmology, Medical School, National and Kapodistrian University of Athens, Athens, Greece; 2Department of Ophthalmology ...
Moschos MM, Nitoda E, Chatziralli IP, Panos GD, Demopoulos CA   +4 more
doaj   +1 more source

Platelet-activating factor receptor plays a role in lung injury and death caused by influenza A in mice [PDF]

, 2010
Influenza A virus causes annual epidemics which affect millions of people worldwide. A recent Influenza pandemic brought new awareness over the health impact of the disease.
Sousa, Lirlandia P., Garcia, Cristina C., Remo C Russo, Salgado, Ana Paula C., Geovanni D. Cassali, Mauro M. Teixeira, Tavares, L.P., Polidoro, Rafael B., Caio T Fagundes, Luciana P Tavares, Tavares, Luciana P., Machado, A.V., Salgado, Ana Paula Carneiro, Rodrigo Guabiraba, Garcia, C.C., Russo, R.C., Cristiana C Garcia, Guabiraba Brito, R., Remo C. Russo, Alexandre V Machado, Machado, Alexandre Vieira, Polidoro, Rafael Barbosa, Caio T. Fagundes, Cassali, Geovanni D., Teixeira, Mauro Martins, Cassali, Geovanni Dantas, Mauro M Teixeira, Lirlândia P. Sousa, Fagundes, C.T., Salgado, A.P.C., Ana Paula C. Salgado, Cassali, G.D., Garcia, Cristiana Couto, Russo, Remo de Castro, Russo, Remo C., Rafael B. Polidoro, Sousa, L.P., Teixeira, M.M., Ana Paula C Salgado, Alexandre V. Machado, Rafael B Polidoro, Machado, Alexandre V., Fagundes, Caio T., Guabiraba, Rodrigo, Cristiana C. Garcia, Polidoro, R.B., Lirlândia P Sousa, Sousa, Lirlândia Pires de, Geovanni D Cassali, Luciana P. Tavares, Teixeira, Mauro M.   +50 more
core   +1 more source

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]

, 2005
Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Siedler, F., Sellmayer, Alois, Gopfert, M. S., Siess, W.   +3 more
core   +1 more source

A Review of Platelet-Activating Factor As a Potential Contributor to Morbidity and Mortality Associated with Severe COVID-19

Clinical and Applied Thrombosis/Hemostasis, 2021
The precise mechanisms of pathology in severe COVID-19 remains elusive. Current evidence suggests that inflammatory mediators are responsible for the manifestation of clinical symptoms that precedes a fatal response to infection. This review examines the
Mark Klein MD, Vinh Dao PharmD, BCPS, Fatima Khan MD, MPH   +2 more
doaj   +1 more source

To hydrolyze or not to hydrolyze: the dilemma of platelet-activating factor acetylhydrolase

Journal of Lipid Research, 2014
Mounting ambiguity persists around the functional role of the plasma form of platelet-activating factor acetylhydrolase (PAF-AH). Because PAF-AH hydrolyzes PAF and related oxidized phospholipids, it is widely accepted as an anti-inflammatory enzyme.
Gopal Kedihitlu Marathe, Chaitanya Pandit, Chikkamenahalli Lakshminarayana Lakshmikanth, Vyala Hanumanthareddy Chaithra, Shancy Petsel Jacob, Cletus Joseph Michael D'Souza   +5 more
doaj   +1 more source

Platelet-activating factor acetyl hydrolase IB2 dysregulated cell proliferation in ovarian cancer

Cancer Cell International, 2021
Background Ovarian cancer is the leading cause of death from gynaecologic illnessed worldwide. Platelet-activating factor acetyl hydrolase IB2 (PAF-AH IB2) is an intracellular serine esterase that hydrolyzes platelet-activating factor, a G-protein-like ...
YingYing He, Zhicheng He, Xiaoyu Zhang, Shubai Liu   +3 more
doaj   +1 more source

Anaphylactic shock depends on endothelial Gq/G11 [PDF]

, 2009
Anaphylactic shock is a severe allergic reaction involving multiple organs including the bronchial and cardiovascular system. Most anaphylactic mediators, like platelet-activating factor (PAF), histamine, and others, act through G protein – coupled ...
Nina Wettschureck, Fleming, Ingrid, Schutz, G., Stefan Offermanns, Fleming, I., Angela Wirth, Habermehl, D., Günther Schütz, Offermanns, S., Fißlthaler, Beate, Wirth, A., Moers, Alexandra, Wettschureck, N., Moers, A., Korhonen, H., Habermehl, Daniel, Ingrid Fleming, Fisslthaler, B., Daniel Habermehl, Offermanns, Stefan, Thomas Wieland, Wieland, Thomas, Beate Fisslthaler, Wieland, T., Alexandra Moers, Korhonen, Hanna, Schütz, Günther, Wettschureck, Nina, Hanna Korhonen, Wirth, Angela   +29 more
core   +1 more source