Results 211 to 220 of about 105,169 (258)
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Radioimmunoassay for platelet‐activating factor
Lipids, 1991AbstractA radioimmunoassay (RIA) for measurement of platelet‐activating factor (PAF) was developed. At a final antiserum dilution of 1∶640, the lowest detection limit of PAF was 0.1 pmol (50 pg). The standard curve obtained was suitable for measurement of PAF in amounts ranging from 0.1 pmol to 30 pmol. The antiserum showed high specificity.
K, Karasawa +5 more
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Hospital Practice, 1983
Our ability to chemically characterize and synthesize this autacoid of allergy and inflammation has given us a unique opportunity to study these important molecules in a highly disciplined fashion. It has also opened the door to a vista of research approaches to define PAF's normal physiologic role as well as its actions as an immunopathologic mediator.
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Our ability to chemically characterize and synthesize this autacoid of allergy and inflammation has given us a unique opportunity to study these important molecules in a highly disciplined fashion. It has also opened the door to a vista of research approaches to define PAF's normal physiologic role as well as its actions as an immunopathologic mediator.
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Platelet Activating Factor Receptors
2003Platelet activating factor (PAF) is a potent pro-inflammatory lipid mediator. Its effects are mediated through cell surface G protein-coupled receptors (GPCRs) that are distributed on numerous cells notably on endothelium [1]. An intracrine mode of action for PAF is proposed based on evidence for intracellular PAF binding sites [2] and retention of ...
A Marilise, Marrache +15 more
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Scandinavian Journal of Gastroenterology, 1996
Platelet-activating factor (PAF) is a proinflammatory lipid. It has been strongly implicated in the regulation of pancreatic exocrine secretion and in the local and systemic events which occur in acute pancreatitis. PAF antagonists, when given as pretreatment, ameliorate the severity of experimental acute pancreatitis by reducing serum amylase ...
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Platelet-activating factor (PAF) is a proinflammatory lipid. It has been strongly implicated in the regulation of pancreatic exocrine secretion and in the local and systemic events which occur in acute pancreatitis. PAF antagonists, when given as pretreatment, ameliorate the severity of experimental acute pancreatitis by reducing serum amylase ...
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Seminal Platelet-Activating Factor
Seminars in Thrombosis and Hemostasis, 2007Platelet-activating factor (PAF; 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphorylcholine) is a potent signaling phospholipid with pleiotropic biologic activities. Since its discovery more than 30 years ago, numerous investigators have documented its presence in a variety of tissues.
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Platelet Factor 3 Activity in Washed Platelets
Thrombosis and Haemostasis, 1973SummaryPlatelets collected with an EDTA solution and simply washed in an incomplete Tyrode’s presented clotting times in the recalcification (man and rat) and the Stypven (rat) tests that were practically identical to those of the PRP when slow speed centrifugation was used (800 G in man, 1000 G in rat). This was demonstrated, in 6 pools of 5 rats each
S, Renaud, P, Gautheron, H, Rosenstein
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Platelet-activating factor acetylhydrolase
Prostaglandins & Other Lipid Mediators, 2002Platelet-activating factor (PAF) is one of the most potent lipid mediators and is involved in a variety of physiological events. The acetyl group at the sn-2 position of its glycerol backbone is required for its biological activity, and deacetylation of PAF induces loss of activity. The deacetylation reaction is catalyzed by PAF-acetylhydrolase (PAF-AH)
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Platelet-activating factor and asthma
Journal of Allergy and Clinical Immunology, 1988anaphylaxis. And if you research into the 1920s) there a very useful treatment in blocking both thrombocyare articles, particularly in the German literature, that topenia and some of the features of anaphylaxis. The report thrombocytopenia as being a feature of clinical first article (1924) stated that heparin totally prevents asthma.
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Platelet-Activating Factor and Platelet-Activating Factor Antagonists in Acute Pancreatitis
Digestive Surgery, 1999<i>Introduction:</i> Acute pancreatitis causes platelet-activating factor (PAF) to be released which induces systemic effects that contribute to circulatory disturbances and multiple organ failure. PAF has also been implicated as a key mediator in the progression of severe acute pancreatitis, which can lead to complications and unacceptably
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Monographs in allergy, 1977
Resume Il existe dans les basophiles et les mastocytes de nombreuses especes de mammiferes un facteur agregeant les plaquettes qui represente par consequent un lien entre la pathologie liee a la degranulation des basophiles/mastocytes, c'est-a-dire l'hypersensibilite immediate, et les plaquettes sanguines.
J, Benveniste, J, Camussi, J, Polonsky
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Resume Il existe dans les basophiles et les mastocytes de nombreuses especes de mammiferes un facteur agregeant les plaquettes qui represente par consequent un lien entre la pathologie liee a la degranulation des basophiles/mastocytes, c'est-a-dire l'hypersensibilite immediate, et les plaquettes sanguines.
J, Benveniste, J, Camussi, J, Polonsky
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