Results 21 to 30 of about 1,044,846 (392)

Platelet activating factor

Ensho, 1981
Susumu Otomo
openalex   +4 more sources

The Roles of Platelet-Activating Factor and Magnesium in Pathophysiology of Hypertension, Atherogenesis, Cardiovascular Disease, Stroke and Aging

Cardiogenetics, 2022
Hypertension and atherosclerosis are debilitating diseases that affect millions each year. Long-term consequences include but are not limited to stroke, myocardial infarction, and kidney failure.
Nilank Shah, Roshni Sethi, Sachin Shah, Komail Jafri, Jonah Duran, Yong Chang, Chirag Soni, Hanna Wollocko   +7 more
doaj   +1 more source

Molecular Docking, Drug likeness Studies and ADMET prediction of Flavonoids as Platelet-Activating Factor (PAF) Receptor Binding [PDF]

Chemical Review and Letters, 2021
Studies and scientific research indicate that the platelet-activating factor (PAF) is a major pro-inflammatory mediator in the initiation and development of cancer.
Mohammed BOUACHRINE, Larbi Elmchichi, Abdellah El Aissouq, Assia BELHASSAN, Hanane Zaki, Abdelkrim Ouammou, Tahar Lakhlifi   +6 more
doaj   +1 more source

Radiation therapy generates platelet-activating factor agonists [PDF]

, 2016
Pro-oxidative stressors can suppress host immunity due to their ability to generate oxidized lipid agonists of the platelet-activating factor-receptor (PAF-R).
Chin-Sinex, Helen Jan, Dynlacht, Joseph R., Garrett, Joy Elizabeth, Harrison, Kathleen A., Johnston II., Michael Edward, Konger, Raymond L., Li, Gengxin, McMullen, Kevin, Mendonca, Marc, Murphy, Robert C., Sahu, Ravi P., Spandau, Dan F., Travers, Jeffrey B., Weyerbacher, Jonathan   +13 more
core   +5 more sources

Factor V activity of platelets: evidence for an activated factor V molecule and for a platelet activator [PDF]

Blood, 1977
Abstract This study was prompted by the observation that fresh platelet suspensions--prepared by gel filtration or albumin density gradient centrifugation--possessed only minimal factor V activity, whereas frozen-and-thawed platelet suspensions possessed striking factor V activity.
Samuel I. Rapaport, Samuel I. Rapaport, Kathrine K. Lavine, Kathrine K. Lavine, Bjarne Østerud, Bjarne Østerud   +5 more
openaire   +4 more sources

Increased platelet activating factor levels in chronic spontaneous urticaria predicts refractoriness to antihistamine treatment: an observational study

Clinical and Translational Allergy, 2019
Background Platelet activating factor (PAF) is an endogenous, active phospholipid released from inflammatory cells, platelets, and endothelial cells, and is involved in the regulation of immune responses. Degradation of PAF by PAF acetylhydrolase (PAF-AH)
Bastsetseg Ulambayar, Eun-Mi Yang, Hyun-Young Cha, Yoo-Seob Shin, Hae-Sim Park, Young-Min Ye   +5 more
doaj   +1 more source

Augmentation of Staphylococcal α-Toxin Signaling by the Epidermal Platelet-Activating Factor Receptor [PDF]

, 2003
Staphylococcal α-toxin is a cytolytic toxin secreted by many strains of Staphylococcus aureus that has proinflammatory and cytotoxic effects on human keratinocytes. α-toxin exerts its effects by forming a transmembrane pore that behaves like an ionophore
Alapatt, Christopher Johnson, Cundell, Dinges, Donald Y.M. Leung, Dy, Ezepchuk, Fink, Grandel, Grimminger, Ishii, Jason Cosgrove, Jeffrey B. Travers, Keith L. Clay, Lemjabbar, Leung, Mallet, Marathe, Mariangela Marques, Markey, Marques, Matsuzawa, Michel, Miwa, Nakamura, Patrick Schlievert, Pei, Prescott, Roth, Song, Stafforini, Suttorp, Tjoelker, Travers, Travers, Travers, Travers, Travers, Travers, Travers, Triggiani, Wakita, Walterscheid   +42 more
core   +1 more source

Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase

Memorias do Instituto Oswaldo Cruz, 2005
Platelet-activating factor (PAF) is one of the most potent lipid mediators involved in inflammatory events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity.
Hugo C Castro Faria Neto, Diana M Stafforini, Stephen M Prescott, Guy A Zimmerman   +3 more
doaj   +1 more source

A Review of Platelet-Activating Factor As a Potential Contributor to Morbidity and Mortality Associated with Severe COVID-19

Clinical and Applied Thrombosis/Hemostasis, 2021
The precise mechanisms of pathology in severe COVID-19 remains elusive. Current evidence suggests that inflammatory mediators are responsible for the manifestation of clinical symptoms that precedes a fatal response to infection. This review examines the
Mark Klein MD, Vinh Dao PharmD, BCPS, Fatima Khan MD, MPH   +2 more
doaj   +1 more source

Forty Years Since the Structural Elucidation of Platelet-Activating Factor (PAF): Historical, Current, and Future Research Perspectives

Molecules, 2019
In the late 1960s, Barbaro and Zvaifler described a substance that caused antigen induced histamine release from rabbit platelets producing antibodies in passive cutaneous anaphylaxis.
R. Lordan, A. Tsoupras, I. Zabetakis, C. Demopoulos   +3 more
semanticscholar   +1 more source