Results 81 to 90 of about 200,980 (357)

Ginkgolide B inhibits the neurotoxicity of prions or amyloid-β_1-42

Journal of Neuroinflammation, 2004
Background Neuronal loss in Alzheimer's or prion diseases is preceded by the accumulation of fibrillar aggregates of toxic proteins (amyloid-β1-42 or the prion protein).
Williams Alun, Salmona Mario, Bate Clive
doaj   +1 more source

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix

Advanced Functional Materials, EarlyView.
This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor   +7 more
wiley   +1 more source

PAR1 Agonists Stimulate APC-Like Endothelial Cytoprotection and Confer Resistance to Thromboinflammatory Injury [PDF]

, 2018
Stimulation of protease-activated receptor 1 (PAR1) on endothelium by activated protein C (APC) is protective in several animal models of disease, and APC has been used clinically in severe sepsis and wound healing.
Aisiku, Omozuanvbo, Ceunynck, Karen De, Chaudhry, Sharjeel A., Dockendorff, Chris, Fitch-Tewfik, Jennifer L., Flaumenhaft, Robert, Higgins, Sarah J., Ingber, Donald E., Jain, Abhishek, Parikh, Samir M., Peters, Christian G.   +10 more
core   +1 more source

Overexpression of Na+/Mg2+ exchanger SLC41A1 attenuates pro-survival signaling [PDF]

, 2017
The Na+/Mg2+ exchanger SLC41A1 (A1), a key component of intracellular Mg homeostasis (IMH), is the major cellular Mg2+ efflux system, and its overexpression decreases [Mg2+]intracellular.
Abdulhanan, Nasrin, Aschenbach, Jörg R., Cibulka, Michal, Fröhlich, Nadine, Kolisek, Martin, Mastrototaro, Lucia, Pilchova, Ivana, Racay, Peter, Röntgen, Monika, Sponder, Gerhard   +9 more
core   +1 more source

Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]

, 2020
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P., Leuvenink, Henri G. D., Nieuwenhuijs-Moeke, Gertrude J., Pischke, Soren E., Ploeg, Rutger J., Pol, Robert A., Sanders, Jan Stephan F., Struys, Michel   +7 more
core   +2 more sources

A Self‐Curling Si3N4‐Biofunctionalized Nerve Wrap for Suture‐Free Peripheral Nerve Repair with Multimodal Regenerative Bioregulation

Advanced Functional Materials, EarlyView.
Si3N4‐enhanced bioactive nanostructured adhesive wrap enables rapid conduit formation in wet environments, simplifying surgical procedures. Incorporated Si3N4 undergoes controlled hydrolysis within nanofibers, multi‐directionally modulating the peripheral nerve repair microenvironment for effective suture‐free repair.
Pengchao Ma, Yihao Liu, Bowen Ren, Chun‐Yi Yang, Xiaobin Luo, Peilun Hu, Jia Yang, Zheng Cao, Keya Mao, Jianheng Liu, Xiumei Wang   +10 more
wiley   +1 more source

Design and Applications of Multi‐Frequency Programmable Metamaterials for Adaptive Stealth

Advanced Functional Materials, EarlyView.
This article provides a comprehensive overview of metamaterials, including their fundamental principles, properties, synthesis techniques, and applications in stealth, as well as their challenges and future prospects. It covers topics that are more advanced than those typically discussed in existing review articles, while still being closely connected ...
Jonathan Tersur Orasugh, Ankita Mohanty, Amit Malakar, Suryasarathi Bose, Suprakas Sinha Ray   +4 more
wiley   +1 more source

Circulating biologically active oxidized phospholipids show on-going and increased oxidative stress in older male mice

Redox Biology, 2013
Background: The biologically active phospholipids Platelet-activating Factor (PAF) and oxidatively truncated phospholipids from chemical oxidation are increased in the circulation of rats subject to the oxidant stress of chronic ethanol ingestion ...
Jinbo Liu, Wei Li, Rui Chen, Thomas M. McIntyre   +3 more
doaj   +1 more source

Adjunctive therapies to reduce thrombotic events in patients with a history of myocardial infarction : role of vorapaxar [PDF]

, 2015
© 2015 Farag et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) LicenseAcute myocardial infarction (AMI) is generally attributed to coronary atherothrombotic ...
Farag, Mohamed, Gorog, Diana A, Patel, Hiten   +2 more
core   +3 more sources

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source