RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists. [PDF]
, 2018 Platelets express ≥2 members of the regulators of G protein signaling (RGS) family. Here, we have focused on the most abundant, RGS10, examining its impact on the hemostatic response in vivo and the mechanisms involved.
Brass, Lawrence F. +7 more
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Role of platelets and platelet receptors in cancer metastasis
Journal of Hematology & Oncology, 2018 The interaction of tumor cells with platelets is a prerequisite for successful hematogenous metastatic dissemination. Upon tumor cell arrival in the blood, tumor cells immediately activate platelets to form a permissive microenvironment.
M. Schlesinger
semanticscholar +1 more source
Japanese Journal of Thrombosis and Hemostasis, 2007 Atherosclerosis is the leading cause of death in patients with diabetes mellitus, increasing mortality in all forms of the disease. Classical risk factors, including hyperlipidemia, hypertension and obesity, do not completely account for the increased incidence of atherosclerosis in diabetes. Some platelet activation markers such as CD62P, CD63, PAC-1,
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Defective ADP-Induced Platelet Factor 3 Activation in Uremia [PDF]
, 1967 Herbert I. Horowitz +3 more
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Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms [PDF]
, 2018 Platelet-activating factor (PAF) stimulates numerous cell types via activation of the G protein-coupled PAF receptor (PAFR). PAFR activation not only induces acute proinflammatory responses, but it also induces delayed systemic immunosuppressive effects ...
FitzGerald, Garret A. +6 more
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Defective Platelet Activation and Bleeding Complications upon Cholestasis in Mice
Cellular Physiology and Biochemistry, 2017 Background/Aims: Platelets are essential mediators of hemostasis to avoid excessive blood loss. Cirrhosis and chronic liver diseases are characterized by alterations in hemostasis.
Nina Sarah Gowert +7 more
doaj +1 more source
Activated protein C inhibits platelet prothrombin-converting activity [PDF]
, 1979 PC Comp, CT Esmon
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Nanoparticle biointerfacing via platelet membrane cloaking
Nature, 2015 Development of functional nanoparticles can be encumbered by unanticipated material properties and biological events, which can affect nanoparticle effectiveness in complex, physiologically relevant systems.
C. J. Hu +21 more
semanticscholar +1 more source
Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor. [PDF]
, 1992 We recently isolated a cDNA clone encoding a functional platelet thrombin receptor that defined a unique mechanism of receptor activation. Thrombin cleaves its receptor's extracellular amino terminal extension, unmasking a new amino terminus that ...
Coughlin, SR +3 more
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Mechanism of complement-mediated activation of human blood platelets in vitro: comparison of normal and paroxysmal nocturnal hemoglobinuria platelets. [PDF]
, 1977 Richard H. Dixon, Wendell F. Rosse
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