Results 101 to 110 of about 4,119,343 (427)

Platelet bioenergetic screen in sickle cell patients reveals mitochondrial complex V inhibition, which contributes to platelet activation.

Blood, 2014
Bioenergetic dysfunction, although central to the pathogenesis of numerous diseases, remains uncharacterized in many patient populations because of the invasiveness of obtaining tissue for mitochondrial studies.
N. Cárdenes, Catherine G. Corey, L. Geary, Shilpa Jain, Sergey I Zharikov, S. Barge, E. Novelli, S. Shiva   +7 more
semanticscholar   +1 more source

Clinical significance of stratifying prostate cancer patients through specific circulating genes

Molecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian, Edouard Jarry, Arynne Santos, Quentin Vesval, Lucie Hamel, Rafael Sanchez‐Salas, Alexis Rompré‐Brodeur, Wassim Kassouf, Raghu Rajan, Fadi Brimo, Marie Duclos, Armen Aprikian, Simone Chevalier   +12 more
wiley   +1 more source

Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function

Cell Reports, 2017
Anucleate platelets circulate in the blood to facilitate thrombosis and diverse immune functions. Platelet activation leading to clot formation correlates with increased glycogenolysis, glucose uptake, glucose oxidation, and lactic acid production ...
Trevor P. Fidler, Robert A. Campbell, Trevor Funari, Nicholas Dunne, Enrique Balderas Angeles, Elizabeth A. Middleton, Dipayan Chaudhuri, Andrew S. Weyrch, E. Dale Abel   +8 more
doaj   +1 more source

Structure and thermodynamics of platelet dispersions [PDF]

Molec. Phys. 106, 1975 (2008), 2008
Various properties of fluids consisting of platelike particles differ from the corresponding ones of fluids consisting of spherical particles because interactions between platelets depend on their mutual orientations. One of the main issues in this topic is to understand how structural properties of such fluids depend on factors such as the shape of ...
arxiv   +1 more source

Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor. [PDF]

, 1992
We recently isolated a cDNA clone encoding a functional platelet thrombin receptor that defined a unique mechanism of receptor activation. Thrombin cleaves its receptor's extracellular amino terminal extension, unmasking a new amino terminus that ...
Coughlin, SR, Hung, DT, Nelken, NA, Vu, TH   +3 more
core   +1 more source

Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation.

Blood, 2014
Platelets are essential in maintaining hemostasis following inflammation or injury to the vasculature. Dysregulated platelet activity often results in thrombotic complications leading to myocardial infarction and stroke.
J. Yeung, Benjamin E. Tourdot, Pilar Fernández-Pérez, J. Vesci, Jin Ren, Christopher J. Smyrniotis, D. Luci, A. Jadhav, A. Simeonov, D. Maloney, T. Holman, S. Mckenzie, M. Holinstat   +12 more
semanticscholar   +1 more source

The roles and applications of extracellular vesicles in cancer

Molecular Oncology, EarlyView.
Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
wiley   +1 more source

Polyphosphate nanoparticles on the platelet surface trigger contact system activation.

Blood, 2017
Polyphosphate is an inorganic polymer that can potentiate several interactions in the blood coagulation system. Blood platelets contain polyphosphate, and the secretion of platelet-derived polyphosphate has been associated with increased thrombus ...
J. Verhoef, A. Barendrecht, Katrin F Nickel, Kim Dijkxhoorn, E. Kenne, L. Labberton, O. McCarty, R. Schiffelers, H. Heijnen, A. Hendrickx, H. Schellekens, M. Fens, S. de Maat, T. Renné, C. Maas   +14 more
semanticscholar   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Evidence of platelet activation in multiple sclerosis

Journal of Neuroinflammation, 2008
Objective A fatality in one multiple sclerosis (MS) patient due to acute idiopathic thrombocytopenic purpura (ITP) and a near fatality in another stimulated our interest in platelet function abnormalities in MS.
Alexander J Steven, Ahn Yeon S, Horstman Lawrence L, Jy Wenche, Sheremata William A, Minagar Alireza   +5 more
doaj   +1 more source