Results 101 to 110 of about 491,468 (315)

Platelet Apoptosis in Adult Immune Thrombocytopenia: Insights into the Mechanism of Damage Triggered by Auto-antibodies [PDF]

, 2016
Mechanisms leading to decreased platelet count in immune thrombocytopenia (ITP) are heterogeneous. This study describes increased platelet apoptosis involving loss of mitochondrial membrane potential (ΔΨm), caspase 3 activation (aCasp3) and ...
Contrufo, Geraldine, Espasandin, Yesica Romina, García, Alejandro Jorge, Glembotsky, Ana Claudia, Goette, Nora Paula, Grodzielski, Matías, Heller, Paula Graciela, Lev, Paola Roxana, Marta, Rosana Fernanda, Molinas, Felisa Concepción, Pierdominici, Marta S., Riveros, Dardo Alberto   +11 more
core   +1 more source

Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals

Advanced Functional Materials, EarlyView.
This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee, Sojin Kim, Myeongeun Lee, Kyoungsuk Jin, Jimin Park   +4 more
wiley   +1 more source

High-mobility group box 1 increases platelet surface P2Y12 and platelet activation in sickle cell disease

JCI Insight
Thrombosis and inflammation are intimately linked and synergistically contribute to the pathogenesis of numerous thromboinflammatory diseases, including sickle cell disease (SCD).
Deirdre Nolfi-Donegan, Gowtham K. Annarapu, Claudette St. Croix, Michael Calderon, Cheryl A. Hillery, Sruti Shiva   +5 more
doaj   +1 more source

Endothelial Cells Angiogenesis in Sulfated Glycosaminoglycan (GAG) Hydrogels Enhanced by Bioactive Glass‐Released Ions

Advanced Functional Materials, EarlyView.
A mechanically tunable hydrogel composed of gelatin, chondroitin sulfate and laminin promotes angiogenesis in vitro without the supplement of growth factors. Endothelial cells morphogenesis was further enhanced by medium conditioned with bioactive glass 58S‐released ions (Ca and Si), thus offering a promising strategy to vascularize 3D tissue ...
Marco Piazzoni, Ilaria Borghi, Francesca Cadamuro, Sophia Dalfino, Riccardo Campanile, Sofia Nizzolo, Valeria Cassina, Francesca Tallia, Julian R. Jones, Francesco Mantegazza, Sabrina Bertini, Lorenzo Moroni, Francesco Nicotra, Laura Russo   +13 more
wiley   +1 more source

Cyclic nucleotides and mitogen-activated protein kinases: regulation of simvastatin in platelet activation

Journal of Biomedical Science, 2010
Background 3-Hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have been widely used to reduce cardiovascular risk. These statins (i.e., simvastatin) may exert other effects besides from their cholesterol-lowering actions ...
Hou Ssu-Yu, Jayakumar Thanasekaran, Chou Duen-Suey, Chen Wei-Fan, Lee Ye-Ming, Lee Jie-Jen, Hsiao George, Sheu Joen-Rong   +7 more
doaj   +1 more source

Impaired factor X and prothrombin activation associated with decreased phospholipid exposure in platelets from a patient with a bleeding disorder [PDF]

, 1985
Jan Rosing, EM Bevers, Paul Comfurius, H.C. Hemker, G. van Dieijen, HJ Weiss, RF Zwaal   +6 more
openalex   +1 more source

Shape‐Morphing Nanoengineered Hydrogel Ribbons as Hemostats

Advanced Functional Materials, EarlyView.
This study introduces a self‐assembling, shape‐morphing nanoengineered hydrogel ribbon system that rapidly forms porous aggregates in situ for efficient hemostasis in trauma and surgical applications. Abstract Rapid and effective hemorrhage control remains a major challenge in trauma and surgical care, particularly for complex or noncompressible wounds.
Ryan Davis Jr, Saptarshi Biswas, Jacob Aragon, Asaf Dana, Jasmine Sureka, Vaaridhi Ramanuja, Jeevika Thazhaiselvam, Sarah E. Miller, Taylor H. Ware, Akhilesh K. Gaharwar   +9 more
wiley   +1 more source

Real-Time Monitoring of Platelet Activation Using Quartz Thickness-Shear Mode Resonator Sensors [PDF]

, 2016
Huiyan Wu, Guangyi Zhao, Hongfei Zu, James H‐C. Wang, Qing‐Ming Wang   +4 more
openalex   +1 more source

Enantioselective Growth of Chiral Serine‐Induced β‐Ag2Se Crystals from an Organoselenium Compound

Advanced Functional Materials, EarlyView.
Chiral amino acids direct the enantioselective crystallization of β‐Ag2Se nanocrystals from an organoselenium precursor. L‐ and D‐serine induce distinct morphologies and opposite homochiral adsorption preferences, transferring molecular handedness into the inorganic lattice.
Matan Oliel, Yarden B. Moshe, Gil Otis, Dana D. Medina, Yitzhak Mastai, Subhomoy Das   +5 more
wiley   +1 more source

Defective Platelet Activation and Bleeding Complications upon Cholestasis in Mice

Cellular Physiology and Biochemistry, 2017
Background/Aims: Platelets are essential mediators of hemostasis to avoid excessive blood loss. Cirrhosis and chronic liver diseases are characterized by alterations in hemostasis.
Nina Sarah Gowert, Meike Klier, Maria Reich, Friedrich Reusswig, Lili Donner, Verena Keitel, Dieter Häussinger, Margitta Elvers   +7 more
doaj   +1 more source