Results 231 to 240 of about 550,426 (284)
Some of the next articles are maybe not open access.
The Coagulant Activity of Platelets
British Journal of Haematology, 1968When platelet‐rich plasma is incubated for 16–20 hours at 37° C. and the platelets are then separated and washed, tissue‐factor activity develops in these platelets. The active platelets accellerate the clotting of plasma samples deficient in Factor XII, XI, IX or VIII, and of normal plasma; the coagulant activity for samples deficient in Factors V ...
K. W. E. Denson +3 more
openaire +3 more sources
Integrins in platelet activation
Journal of Thrombosis and Haemostasis, 2009Heterodimeric receptors of the beta1 and beta3 integrin families mediate platelet adhesion and aggregation in hemostasis and thrombosis. In resting platelets, integrins are expressed in a low-affinity state but they shift to a high-affinity state and efficiently bind their ligands in response to cellular activation.
David Varga-Szabo +2 more
openaire +3 more sources
Platelet activation in preeclampsia
American Journal of Obstetrics and Gynecology, 1985Platelet activation was assessed in hospitalized third-trimester patients with preeclampsia (n = 11) or chronic hypertension with superimposed preeclampsia (n = 11) and in healthy outpatient pregnant controls (n = 10) by measuring plasma beta-thromboglobulin, platelet factor 4, the platelet aggregate ratio, and the amount of collagen required to ...
Karen A. Rehnberg +4 more
openaire +5 more sources
Activated platelets and atherosclerosis
Expert Review of Cardiovascular Therapy, 2010Several studies suggest an important role for platelets in atherogenesis, not only as mediators of thrombus formation, but also as inducers of inflammation. Several lines of evidence indicate that platelets are potent inflammatory cells that induce inflammatory responses in adjacent cells such as leukocytes and endothelial cells.
Thor Ueland +7 more
openaire +3 more sources
Blood, 2009
To the editor: Protein kinase C (PKC) is a central regulator of platelet activation, and individual PKC isoforms are likely to have distinct roles.[1][1] We and others had previously reported roles for the novel PKC isoform, PKCθ, in integrin signaling[2][2] and platelet function.[3][3] The ...
Matthew T. Harper, Alastair W. Poole
openaire +3 more sources
To the editor: Protein kinase C (PKC) is a central regulator of platelet activation, and individual PKC isoforms are likely to have distinct roles.[1][1] We and others had previously reported roles for the novel PKC isoform, PKCθ, in integrin signaling[2][2] and platelet function.[3][3] The ...
Matthew T. Harper, Alastair W. Poole
openaire +3 more sources
Platelets and Plasminogen Activation
Thrombosis and Haemostasis, 1995Platelets serve as a site for assembly of the proteins of the plasminogen activator system. Once bound to the platelet surface, tissue-type plasminogen activator manifests enhanced catalytic activity. Plasmin, once formed, also binds to the platelets surface and, at low concentrations, renders the platelet dysfunctional by cleaving glycoprotein IIIa ...
Joseph Loscalzo +3 more
openaire +3 more sources
Headache: The Journal of Head and Face Pain, 1982
SYNOPSISMigraine is a disease associated with increased platelet activity.The aim of this paper was to study "in vivo" platelet activation by assessing platelet serotonin (5HT) content and beta‐thromboglobulin (B‐TG) and platelet factor four (PF4) plasma levels, in headache‐free‐periods and during migraine attacks.In headache‐free‐periods, there was no
Francesco Ferro Milone +3 more
openaire +3 more sources
SYNOPSISMigraine is a disease associated with increased platelet activity.The aim of this paper was to study "in vivo" platelet activation by assessing platelet serotonin (5HT) content and beta‐thromboglobulin (B‐TG) and platelet factor four (PF4) plasma levels, in headache‐free‐periods and during migraine attacks.In headache‐free‐periods, there was no
Francesco Ferro Milone +3 more
openaire +3 more sources
Platelet activation by heparin
Blood, 2011In this issue of Blood , Gao et al provide important insights into the proactivating effects of negatively charged anticoagulants on platelets.[1][1] They show outside-in signaling via the glycoprotein (GP) IIb-IIIa complex (integrin αIIbβ3) induced by heparin, low molecular weight heparin ...
openaire +3 more sources
Stress and Platelet Activation
Acta Haematologica, 1983Severe stress, with increased secretion of adrenaline, is likely to cause platelet activation. The aim of the present study was to investigate if moderate stress, which usually is not accompanied by adrenaline secretion, could induce activation of platelets, as measured by changes in the plasma concentrations of platelet factor 4 (PF-4).
Lennart Hansson +3 more
openaire +3 more sources
2007
Platelet-activating factor (PAF) is a potent mediator that occurs at very low concentrations in cells and tissues. Accurate quantitation of PAF has always been difficult because of the physicochemical properties of PAF and its structural similarity to several much more abundant phospholipids.
Robert L. Wykle +2 more
openaire +3 more sources
Platelet-activating factor (PAF) is a potent mediator that occurs at very low concentrations in cells and tissues. Accurate quantitation of PAF has always been difficult because of the physicochemical properties of PAF and its structural similarity to several much more abundant phospholipids.
Robert L. Wykle +2 more
openaire +3 more sources