Results 261 to 270 of about 467,395 (313)
Some of the next articles are maybe not open access.
Scandinavian Journal of Gastroenterology, 1996
Platelet-activating factor (PAF) is a proinflammatory lipid. It has been strongly implicated in the regulation of pancreatic exocrine secretion and in the local and systemic events which occur in acute pancreatitis. PAF antagonists, when given as pretreatment, ameliorate the severity of experimental acute pancreatitis by reducing serum amylase ...
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Platelet-activating factor (PAF) is a proinflammatory lipid. It has been strongly implicated in the regulation of pancreatic exocrine secretion and in the local and systemic events which occur in acute pancreatitis. PAF antagonists, when given as pretreatment, ameliorate the severity of experimental acute pancreatitis by reducing serum amylase ...
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Integrins in platelet activation
Journal of Thrombosis and Haemostasis, 2009Heterodimeric receptors of the beta1 and beta3 integrin families mediate platelet adhesion and aggregation in hemostasis and thrombosis. In resting platelets, integrins are expressed in a low-affinity state but they shift to a high-affinity state and efficiently bind their ligands in response to cellular activation.
B, Nieswandt, D, Varga-Szabo, M, Elvers
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Blood, 2009
To the editor: Protein kinase C (PKC) is a central regulator of platelet activation, and individual PKC isoforms are likely to have distinct roles.[1][1] We and others had previously reported roles for the novel PKC isoform, PKCθ, in integrin signaling[2][2] and platelet function.[3][3] The ...
Matthew T, Harper, Alastair W, Poole
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To the editor: Protein kinase C (PKC) is a central regulator of platelet activation, and individual PKC isoforms are likely to have distinct roles.[1][1] We and others had previously reported roles for the novel PKC isoform, PKCθ, in integrin signaling[2][2] and platelet function.[3][3] The ...
Matthew T, Harper, Alastair W, Poole
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ADP-lnduced Platelet Activation
Critical Reviews in Biochemistry and Molecular Biology, 1997Platelet activation is central to the pathogenesis of hemostasis and arterial thrombosis. Platelet aggregation plays a major role in acute coronary artery diseases, myocardial infarction, unstable angina, and stroke. ADP is the first known and an important agonist for platelet aggregation.
Rajinder N. Puri +2 more
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Platelets and Plasminogen Activation
Thrombosis and Haemostasis, 1995Platelets serve as a site for assembly of the proteins of the plasminogen activator system. Once bound to the platelet surface, tissue-type plasminogen activator manifests enhanced catalytic activity. Plasmin, once formed, also binds to the platelets surface and, at low concentrations, renders the platelet dysfunctional by cleaving glycoprotein IIIa ...
J, Loscalzo +3 more
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Activated platelets and atherosclerosis
Expert Review of Cardiovascular Therapy, 2010Several studies suggest an important role for platelets in atherogenesis, not only as mediators of thrombus formation, but also as inducers of inflammation. Several lines of evidence indicate that platelets are potent inflammatory cells that induce inflammatory responses in adjacent cells such as leukocytes and endothelial cells.
Pål, Aukrust +7 more
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Platelet activation in preeclampsia
American Journal of Obstetrics and Gynecology, 1985Platelet activation was assessed in hospitalized third-trimester patients with preeclampsia (n = 11) or chronic hypertension with superimposed preeclampsia (n = 11) and in healthy outpatient pregnant controls (n = 10) by measuring plasma beta-thromboglobulin, platelet factor 4, the platelet aggregate ratio, and the amount of collagen required to ...
M L, Socol +4 more
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Seminal Platelet-Activating Factor
Seminars in Thrombosis and Hemostasis, 2007Platelet-activating factor (PAF; 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphorylcholine) is a potent signaling phospholipid with pleiotropic biologic activities. Since its discovery more than 30 years ago, numerous investigators have documented its presence in a variety of tissues.
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Platelet-activating factor antagonists
Clinical Reviews in Allergy, 1995The great number of PAF antagonists reviewed in this article clearly shows the tremendous effort made in the last 20 yr to explore the complex biological background of the mechanism of action of PAF and the potential clinical benefit of its antagonists. It is obvious that now highly potent, long-acting, and perorally applicable PAF-receptor antagonists
M, Koltai, P G, Braquet
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Platelet activation by heparin
Blood, 2011In this issue of Blood , Gao et al provide important insights into the proactivating effects of negatively charged anticoagulants on platelets.[1][1] They show outside-in signaling via the glycoprotein (GP) IIb-IIIa complex (integrin αIIbβ3) induced by heparin, low molecular weight heparin ...
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