Results 261 to 270 of about 478,140 (363)

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, EarlyView.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source

Role of Reactive Oxygen Species in Collagen-Induced Platelet Activation and the Protective Effects of Antioxidants. [PDF]

Antioxidants (Basel)
Han JY, Utsumi H, Chung HY.
europepmc   +1 more source

Physiological pH Transition‐Driven Protein Corona Dynamics Regulate Cellular Uptake and Inflammatory Responses of Silica Nanoparticles

Advanced Science, EarlyView.
Physiological pH transitions modulate protein corona dynamics on nanoparticles, altering their cellular uptake and inflammatory responses. Acidic pHs enhance protein adsorption, induce structural changes, and promote cellular uptake. Simultaneously, inflammatory responses are reduced due to altered protein composition, including decreased ...
Yuting Ge, Fangqin Fu, Yu Gao, Tianchang He, Volker Mailänder, Daniel Crespy, Katharina Landfester, Shuai Jiang   +7 more
wiley   +1 more source

Dioscin from smilax china rhizomes inhibits platelet activation and thrombus formation via up-regulating cyclic nucleotides. [PDF]

Sci Rep
Lee GH, Lee JP, Heo NY, Lee CD, Kim G, Wahab AA, Rhee MH, Lee S, Lee DH.   +8 more
europepmc   +1 more source

A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions.

, 1983
Ken‐Ichi Sano, Yoshimi Takai, Junji Yamanishi, Yasutomi Nishizuka   +3 more
openalex   +1 more source

Phase‐Change Materials for Volatile Threshold Resistive Switching and Neuronal Device Applications

Advanced Science, EarlyView.
Volatile threshold switching materials are an important pathway to simulate neuronal behavior. This review summarizes recent advances in the development of volatile resistive switching devices and neuronal oscillators based on three representative phase change materials, emphasizes the major challenges in this rapidly evolving field, and provides an ...
Huandong Chen, Jayakanth Ravichandran
wiley   +1 more source

Procoagulant platelet activation promotes venous thrombosis.

Blood
Kaiser R, Dewender R, Mulkers M, Stermann J, Rossaro D, Di Fina L, Li L, Gold C, Schmid M, Kääb L, Eivers L, Akgöl S, Yue K, Kammerer L, Loew Q, Anjum A, Escaig R, Akhalkatsi A, Laun L, Kranich J, Brocker T, Mueller TT, Krächan A, Gmeiner J, Pekayvaz K, Thienel M, Massberg S, Stark K, Kilani B, Nicolai L.   +29 more
europepmc   +1 more source

iMer, a naturally occurring MERTK splice variant, binds to GAS6 to decrease platelet activation and thrombus formation. [PDF]

Blood Vessel Thromb Hemost
Springborn S, Judd S, Morateck P, VanderZee D, Kidwell A, Brzezinski C, Cox A, Sather S, Neeves KB, DeRyckere D, Di Paola J, Graham DK, Branchford BR.   +12 more
europepmc   +1 more source

Targeting Multilayered Metabolic Networks in Brain Diseases: Emerging Perspectives on Nanodelivery Strategies

Advanced Science, EarlyView.
Brain diseases involve multilayered metabolic disruptions that reshape cellular interactions and microenvironments. This review outlines core metabolic features across disease states and presents emerging nanodelivery strategies as precision tools to reprogram pathological metabolism.
Jingyi Zhou, Chen Jiang
wiley   +1 more source