Results 321 to 330 of about 4,080,787 (408)

Ultrasound‐Induced Nitric Oxide‐Propelled Nanomotor for Multimodal Theranostics of Cancer with Deep Penetration and Extended Lifetime

Advanced Science, EarlyView.
A hollow nanomotor (PM‐HMSN/Arg) propelled by ultrasound‐triggered nitric oxide (NO) was developed. The nanomotor employs a “tethering‐relaxing‐drilling” mechanism to overcome biological barriers, enabling multimodal theranostics of cancer with deep penetration and extended lifetime.
Xue Xu, Jinxu Cao, Yan Mu, Hao Zhang, Ya‐Lei Wang, Mengzhen Chen, Yuce Li, Qian Hua   +7 more
wiley   +1 more source

Apoptotic Vesicles Attenuate Acute Lung Injury <i>via</i> CD73-Mediated Inhibition of Platelet Activation and NETosis. [PDF]

Int J Nanomedicine
Tan L, Zhang C, Kou X, Zhao L, Wu D, Li J, Yu C, Xu T, Gao L, Mao X, Zhao C.   +10 more
europepmc   +1 more source

Maximizing Efficacy of Cancer Nanovaccines and Immune Cells Landscape in Responders and Non‐Responders to Immunotherapy

Advanced Science, EarlyView.
To maximize the efficacy of cancer vaccines, adjuvants, collection, lysis, purification, oxidation, loading sites, and sizes, etc., are investigated. The optimized cancer nanovaccines loading whole tumor antigens can cure all or most tumor‐bearing mice in multiple mouse cancer models.
Xiangxiang Xu, Lu Diao, Jin Wang, Ao Zhu, Xianlan Chen, Yan Zheng, Yuhan Liu, Kang Hu, Jiashan Zhu, Cheng Ding, Chang Li, Yunzhi Pan, Jun Zhao, Mi Liu   +13 more
wiley   +1 more source

Platelet activation near point-like source of agonist: Experimental insights and computational model. [PDF]

PLoS One
Starodubtseva ES, Karogodina TY, Moskalensky AE.   +2 more
europepmc   +1 more source

Rictor Ameliorates Acute Antibody‐Mediated Rejection Following Kidney Transplantation by Suppressing Macrophage M1 Polarization Through p65‐NLRP3 Axis

Advanced Science, EarlyView.
This study elucidates the critical role of Rictor in macrophage activation in acute antibody‐mediated rejection (ABMR). Rictor increases K48‐linked ubiquitination of p65 by upregulating E3 ubiquitin ligase SOCS1, inhibiting transcriptional levels of NLRP3 and inflammasome activation.
Bin Ni, Chengcheng Yang, Junqi Zhang, Zhou Hang, Ming Zheng, Dengyuan Feng, Qinghuan Shen, Jinxu Miao, Xulin Sun, Li Sun, Baixin Shen, Min Gu, Zijie Wang   +12 more
wiley   +1 more source

Dual‐Energy CT‐Based Assessment of Thrombotic Heterogeneity for Predicting Stroke Source and Response to Machine Thrombectomy: A Step Toward Visualization Thrombus Treatment

Advanced Science, EarlyView.
The research indicates that dual energy CT scanning can accurately predict the stroke source and clinical outcomes by analyzing thrombus heterogeneity. Based on histopathological analysis of thrombus components, these scans are better able to display thrombus details than standard CT scans, which is helpful for the development of visual navigation ...
Jingxuan Jiang, Sijia Wang, Fan Xiao, Hongmei Gu, Mingkang Wang, Hao Tian, Baohui Guan, Kai Sheng, Yijia Xiong, Huilin Zhao, Minda Li, Li Xu, Zheng Sun, Haiyan Du, Wenxian Du, Yuehua Li   +15 more
wiley   +1 more source

Oxygen Concentration Plays a Critical Role in Fibrinogen-Mediated Platelet Activation via Inactivation of α_IIbβ₃ and Modulation of Fibrinogen. [PDF]

Biomolecules
Leonard SVL, Booth Z, Naylor-Adamson L, Bibby L, Wraith KS, Pula G, Arman M, Calaminus SDJ.   +7 more
europepmc   +1 more source

Red Blood Cell‐Induced Bacterial Margination Improves Microbial Hemoadsorption on Engineered Cell‐Depleted Thrombi, Restoring Severe Bacteremia in Rats

Advanced Science, EarlyView.
A highly efficient extracorporeal device for treating bacteremia is developed by integrating microfluidic bacterial margination and engineered cell‐depleted thrombi strategically constructed in the device. The rodent models, severely infected with antibiotic‐resistant bacteria, recover from bacteremia after two subsequent extracorporeal blood ...
Bong Hwan Jang, Su Hyun Jung, Seyong Kwon, Sung Jin Park, Joo H. Kang   +4 more
wiley   +1 more source

Platelet activation through CD62P and the formation of platelet-monocyte complexes are associated with the exacerbation of mucosal inflammation in patients with ulcerative colitis. [PDF]

Sci Rep
Sano Y, Tomiyama T, Yagi N, Ito Y, Honzawa Y, Tahara T, Ikeura T, Fukui T, Shimoda S, Naganuma M.   +9 more
europepmc   +1 more source

Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer

Advanced Science, EarlyView.
This review compares clinical outcomes, translational progress, and global funding trends across cancer phototherapies—photodynamic, photothermal, and photoimmunotherapy—and conventional immunotherapy. It highlights differences in treatment efficacy, clinical trial status, financial investment, and regulatory challenges, providing a comprehensive ...
Deepak S. Chauhan, Kun Shao, Roopa Hebbandi Nanjundappa, Daniel‐Jiajun Yu, Marianne Stanford, Huile Gao, Channakeshava Sokke Umeshappa   +6 more
wiley   +1 more source