Results 71 to 80 of about 4,071,532 (408)

Effects of eltrombopag on platelet count and platelet activation in Wiskott-Aldrich syndrome/X-linked thrombocytopenia.

Blood, 2015
UNLABELLED Because Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT) patients have microthrombocytopenia, hemorrhage is a major problem.
A. J. Gerrits, Emily A Leven, A. Frelinger, Sophie L. Brigstocke, M. Berny-Lang, W. Beau Mitchell, S. Revel-Vilk, H. Tamary, S. L. Carmichael, M. Barnard, A. Michelson, J. Bussel   +11 more
semanticscholar   +1 more source

The Underestimated Role of Platelets in Severe Infection a Narrative Review

Cells, 2022
Beyond their role in hemostasis, platelets have emerged as key contributors in the immune response; accordingly, the occurrence of thrombocytopenia during sepsis/septic shock is a well-known risk factor of mortality and a marker of disease severity ...
Alberto Fogagnolo, Gianluca Calogero Campo, Matilde Mari, Graziella Pompei, Rita Pavasini, Carlo Alberto Volta, Savino Spadaro   +6 more
doaj   +1 more source

Functional redundancy between RAP1 isoforms in murine platelet production and function [PDF]

, 2018
RAP GTPases, important regulators of cellular adhesion, are abundant signaling molecules in the platelet/megakaryocytic lineage. However, mice lacking the predominant isoform, RAP1B, display a partial platelet integrin activation defect and have a ...
Becker, Bergmeier, Bermejo, Bertozzi, Bertozzi, Bokoch, Bos, Boudreaux, Boulaftali, Boulaftali, Bouschet, Burkhart, Canault, Cattaneo, Christopher I. Jones, Chrzanowska-Wodnicka, Chrzanowska-Wodnicka, Crittenden, Dan O. Kechele, David S. Paul, Deppermann, Dorsaf Ghalloussi, Durrant, Ellen C. O'Shaughnessy, Eto, Garcia, Getz, Gloerich, Goerge, Gros, Han, Ho-Tin-Noé, Jonathan M. Gibbins, Kamata, Kamata, Kasirer-Friede, Kathleen M. Caron, Kathryn O. Poe, Kato, Klapproth, Klaus M. Hahn, Lee, Lee, Lenter, Li, Li, Lin, Lozano, Lucia Stefanini, Mazharian, Molina-Ortiz, Moore, Moser, Nieswandt, Nieswandt, Nonaka, Pan, Petrich, Piatt, Pleines, Qu, Raaijmakers, Raymond Piatt, Robert H. Lee, Rowley, Shattil, Simon, Stalker, Stefanini, Stefanini, Stefanini, Stefanini, Stefanini, Stolla, Stork, Stritt, Su, Suzuki-Inoue, Séverin, Taira, Tiedt, Wang, Watanabe, Watkins, Westbury, Wittchen, Wolfgang Bergmeier, Yacine Boulaftali, Yue, Zeiler, Zhang, Zhu   +91 more
core   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Anti-HLA antibodies with complementary and synergistic interaction geometries promote classical complement activation on platelets

Haematologica, 2019
High titers of HLA antibodies are associated with platelet refractoriness, causing poor platelet increments after transfusions in a subset of patients with HLA antibodies.
Maaike Rijkers, David Schmidt, Nina Lu, Cynthia S.M. Kramer, Sebastiaan Heidt, Arend Mulder, Leendert Porcelijn, Frans H.J. Claas, Frank W.G. Leebeek, A.J. Gerard Jansen, Ilse Jongerius, Sacha S. Zeerleder, Gestur Vidarsson, Jan Voorberg, Masja de Haas   +14 more
doaj   +1 more source

Platelet activation determines angiopoietin-1 and VEGF levels in malaria: implications for their use as biomarkers. [PDF]

PLoS ONE, 2014
INTRODUCTION: The angiogenic proteins angiopoietin (Ang)-1, Ang-2 and vascular endothelial growth factor (VEGF) are regulators of endothelial inflammation and integrity.
Judith Brouwers, Rintis Noviyanti, Rob Fijnheer, Philip G de Groot, Leily Trianty, Siti Mudaliana, Mark Roest, Din Syafruddin, Andre van der Ven, Quirijn de Mast   +9 more
doaj   +1 more source

CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation [PDF]

, 2003
CD40 is a 48-kDa phosphorylated transmembrane glycoprotein belonging to the TNF receptor superfamily. CD40 has been demonstrated on a range of cell types, and it has an important role in adaptive immunity and inflammation.
Callard, R.E., Inwald, D.P., Klein, N.J., McDowall, A., Peters, M.J.   +4 more
core  

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Increased Thrombopoiesis and Platelet Activation in Hantavirus-Infected Patients.

Journal of Infectious Diseases, 2015
BACKGROUND Thrombocytopenia is a common finding during viral hemorrhagic fever, which includes hemorrhagic fever with renal syndrome (HFRS). The 2 main causes for thrombocytopenia are impaired thrombopoiesis and/or increased peripheral destruction of ...
Anne-Marie Connolly-Andersen, E. Sundberg, C. Ahlm, J. Hultdin, M. Baudin, J. Larsson, E. Dunne, D. Kenny, T. Lindahl, S. Ramström, Sofie Nilsson   +10 more
semanticscholar   +1 more source

SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19

Journal of Hematology & Oncology, 2020
Background Critically ill patients diagnosed with COVID-19 may develop a pro-thrombotic state that places them at a dramatically increased lethal risk. Although platelet activation is critical for thrombosis and is responsible for the thrombotic events ...
Shenmin Zhang, Yangyang Liu, Xiaofang Wang, Li Yang, Haishan Li, Yuyan Wang, Mengduan Liu, Xiaoyan Zhao, Youhua Xie, Yan Yang, Shenghui Zhang, Zhichao Fan, Jianzeng Dong, Zhenghong Yuan, Z. Ding, Yi Zhang, Liang Hu   +16 more
semanticscholar   +1 more source