Results 71 to 80 of about 4,112,530 (307)

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization,secondary mediators, and Rac [PDF]

, 2010
The C-type lectin-like receptor 2 (CLEC-2)activates platelets through Src and Syk tyrosine kinases via a single cytoplasmic YxxL motif known as a hem immunoreceptor tyrosine-based activation motif (hemITAM).Here, we demonstrate using sucrose gradient ...
Alice Y. Pollitt, Atkinson, Barrow, Beata Grygielska, Bertrand Leblond, Bodin, Bodin, Boggon, Christou, Colonna, Eble, Ezumi, Fuller, He, Hooley, Hughes, Huysamen, Johannes A. Eble, Kerrigan, Laurent Désiré, Lee, Locke, May, McCarty, Pestina, Piechulek, Pierce, Pleines, Quek, Sancho, Schacht, Shutes, Simons, Sobanov, Spalton, Steve P. Watson, Suzuki-Inoue, Suzuki-Inoue, Tolias, Walliser, Watson, Watson, Wonerow, Wonerow, Xu   +44 more
core   +1 more source

Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function

Cell Reports, 2017
Anucleate platelets circulate in the blood to facilitate thrombosis and diverse immune functions. Platelet activation leading to clot formation correlates with increased glycogenolysis, glucose uptake, glucose oxidation, and lactic acid production ...
Trevor P. Fidler, Robert A. Campbell, Trevor Funari, Nicholas Dunne, Enrique Balderas Angeles, Elizabeth A. Middleton, Dipayan Chaudhuri, Andrew S. Weyrch, E. Dale Abel   +8 more
doaj   +1 more source

Entecavir as a P2X7R antagonist ameliorates platelet activation and thrombus formation

Journal of Pharmacological Sciences, 2020
Platelet activation is the primary cause of thrombosis. The P2X7 receptor (P2X7R) is a therapeutic target of thrombosis. However, it is still unknown whether P2X7R activation affects platelet thrombus.
Yue Ming, Guang Xin, Beihong Ji, Chengji Ji, Zeliang Wei, Boli Zhang, Junhua Zhang, Kui Yu, Xiaoyu Zhang, Shiyi Li, Youping Li, Zhihua Xing, Hai Niu, Wen Huang   +13 more
doaj   +1 more source

Effects of High Flavanol Dark Chocolate on Cardiovascular Function and Platelet Aggregation. [PDF]

, 2015
Regular consumption of chocolate and cocoa products has been linked to reduced cardiovascular mortality. This study compared the effects of high flavanol dark chocolate (HFDC; 1064mg flavanols/day for 6 weeks) and low flavanol dark chocolate (LFDC; 88mg ...
Akita, Armstrong, Atholl Johnston, Avolio, Balzer, Buijsse, Buijsse, Butcher, Curtis, Curtis, Custodis, David J. Collier, Duprez, Engler, Flammer, Flammer, Fredholm, Grassi, Grassi, Gresele, Gu, Gurvinder Rull, Heiss, Hermann, Holland, Holt, Innes, Janszky, Julian Shiel, Kokubo, Kris-Etherton, Kris-Etherton, Lakatta, Langer, Larsson, Larsson, Laurent, Lopez-Garcia, Manisty, Martina H. Lundberg, Murphy, Pereira, Rambaran, Rein, Ried, Roger Corder, Schroeter, Sever, Sharman, Smolenski, Taubert, Thorin, Timothy D. Warner, Varughese, Williams, Yu, Zetty N. Mohd-Zain   +56 more
core   +1 more source

Platelet-Derived Inhibitors of Platelet Activation [PDF]

, 2017
Negative regulators of platelet activation are a relatively unexplored aspect of platelet physiology yet have an important role in tempering thrombus development by contributing much needed negative regulation to a process that is amplified by several positive feedback mechanisms.
Unsworth, AJ, Bye, AP, Gibbins, JM
openaire   +2 more sources

Serotonin reuptake inhibitors and cardiovascular disease [PDF]

, 2005
Selective serotonin re-uptake inhibiting drugs (SSRIs) are widely used for endogenous depression. In addition to depleting the nerve terminals of serotonin they also lower blood platelet serotonin levels.
Belcher, P.R., Drake-Holland, A.J., Noble, M.   +2 more
core   +1 more source

Complement C3 inhibition reduces complement activation in clinical platelet concentrates but does not counteract platelet storage lesions

Platelets
Platelet storage is associated with storage lesions, including platelet morphological changes and a gradual functional loss. We investigated the impact of complement C3 inhibition on complement activation and platelet storage lesions in clinical platelet
Linnea I. Andersson, Per Sandgren, Dick J. Sjöström, Camilla Mohlin, Kim Hägerström, Ivar Tjernberg, Tom Eirik Mollnes, Per H. Nilsson   +7 more
doaj   +1 more source

Evidence of platelet activation in multiple sclerosis

Journal of Neuroinflammation, 2008
Objective A fatality in one multiple sclerosis (MS) patient due to acute idiopathic thrombocytopenic purpura (ITP) and a near fatality in another stimulated our interest in platelet function abnormalities in MS.
Alexander J Steven, Ahn Yeon S, Horstman Lawrence L, Jy Wenche, Sheremata William A, Minagar Alireza   +5 more
doaj   +1 more source

The effects of arterial flow on platelet activation, thrombus growth, and stabilization [PDF]

, 2017
Injury of an arterial vessel wall acutely triggers a multifaceted process of thrombus formation, which is dictated by the high-shear flow conditions in the artery. In this overview, we describe how the classical concept of arterial thrombus formation and
Angelillo-Scherrer, Anne, Cosemans, Judith M.E.M., Heemskerk, Johan W.M., Mattheij, Nadine J.A.   +3 more
core  

The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation [PDF]

, 2016
A dynamic, properly organised actin cytoskeleton is critical for the production and haemostatic function of platelets. The Wiskott Aldrich Syndrome protein (WASp) and Actin-Related Proteins 2 & 3 Complex (Arp2/3 complex) are critical mediators of ...
Bem, Danai, Finney, Brenda, Machesky, Laura M., Poulter, Natalie S., Thomas, Steven G., Watson, Stephen P.   +5 more
core   +4 more sources