Results 71 to 80 of about 4,119,343 (427)

Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis.

Blood, 2015
Autophagy is important for maintaining cellular homeostasis, and thus its deficiency is implicated in a broad spectrum of human diseases. Its role in platelet function has only recently been examined.
Madhu M Ouseph, Yunjie Huang, M. Banerjee, Smita Joshi, L. MacDonald, Yu Zhong, Huijuan Liu, Xianting Li, B. Xiang, Guoying Zhang, M. Komatsu, Zhenyu Yue, Zhenyu Li, B. Storrie, S. Whiteheart, Qing Jun Wang   +15 more
semanticscholar   +1 more source

Transmission matrix of a uniaxial optically active crystal platelet [PDF]

, 2005
Expressions corresponding to the transmission of a uniaxial optically active crystal platelet are provided for an optical axis parallel and perpendicular to the plane of interface. The optical activity is taken into account by a consistent multipolar expansion of the crystal medium response due to the path of an electromagnetic wave. Numerical examples
arxiv   +1 more source

RASA3 is a critical inhibitor of RAP1-dependent platelet activation.

Journal of Clinical Investigation, 2015
The small GTPase RAP1 is critical for platelet activation and thrombus formation. RAP1 activity in platelets is controlled by the GEF CalDAG-GEFI and an unknown regulator that operates downstream of the adenosine diphosphate (ADP) receptor, P2Y12, a ...
L. Stefanini, David S. Paul, R. Robledo, E. R. Chan, T. Getz, Robert A. Campbell, Daniel O. Kechele, C. Casari, Raymond Piatt, K. Caron, N. Mackman, A. Weyrich, M. C. Parrott, Y. Boulaftali, M. Adams, L. Peters, W. Bergmeier   +16 more
semanticscholar   +1 more source

The Underestimated Role of Platelets in Severe Infection a Narrative Review

Cells, 2022
Beyond their role in hemostasis, platelets have emerged as key contributors in the immune response; accordingly, the occurrence of thrombocytopenia during sepsis/septic shock is a well-known risk factor of mortality and a marker of disease severity ...
Alberto Fogagnolo, Gianluca Calogero Campo, Matilde Mari, Graziella Pompei, Rita Pavasini, Carlo Alberto Volta, Savino Spadaro   +6 more
doaj   +1 more source

The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis [PDF]

, 2009
Platelets play a fundamental role in hemostasis and thrombosis. They are also involved in pathologic conditions resulting from blocked blood vessels, including myocardial infarction and ischemic stroke.
Abtahian, Alexandra Mazharian, Arias-Salgado, Arias-Salgado, Arthur Weiss, Asselin, Auger, Avecilla, Baker, Best, Best, Cheli, Choudhuri, Dhanjal, Dorahy, Dubois, Ezumi, Gibbins, Gibbins, Harper, Hermiston, Holsinger, Jenson Lim, Jing W. Zhu, Jocelyn M. Auger, Kalia, Kato, Klages, Kovalenko, Kralisz, Kristin N. Kornerup, Le Pera, Lin, Lin, Liu, Mangin, McCarty, McNeill, Michael G. Tomlinson, Minuz, Moarefi, Mocsai, Morton, Neena Kalia, Nonne, Obergfell, Palka, Park, Pasquet, Pasquet, Pasquet, Pearce, Poole, Quek, Senis, Snell, Somani, Sorby, Steve G. Thomas, Steve P. Watson, Stuart Ellison, Superti-Furga, Suzuki-Inoue, Suzuki-Inoue, Tarvinder Dhanjal, Tsuboi, Vandendries, Wagner, Watanabe, Watson, Wonerow, Woodside, Xu, Xu, Yamaguchi, Yan Zhao, Yotis A. Senis, Young, Zhang, Zhu   +79 more
core   +2 more sources

Distinct phenotypes of platelet, monocyte, and neutrophil activation occur during the acute and convalescent phase of COVID-19 [PDF]

, 2021
SARS-CoV-2 has spread rapidly worldwide, causing the COVID-19 pandemic. Platelet activation and platelet-leukocyte complex formation are proposed to contribute to disease progression.
Bläckberg, Anna, Chao, Yashuan, Hovold, Gisela, Rasmussen, Magnus, Rebetz, Johan, Semple, John W., Shannon, Oonagh, Sunnerhagen, Torgny   +7 more
core   +1 more source

Effects of eltrombopag on platelet count and platelet activation in Wiskott-Aldrich syndrome/X-linked thrombocytopenia.

Blood, 2015
UNLABELLED Because Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT) patients have microthrombocytopenia, hemorrhage is a major problem.
A. J. Gerrits, Emily A Leven, A. Frelinger, Sophie L. Brigstocke, M. Berny-Lang, W. Beau Mitchell, S. Revel-Vilk, H. Tamary, S. L. Carmichael, M. Barnard, A. Michelson, J. Bussel   +11 more
semanticscholar   +1 more source

Glycoprotein Ib activation by thrombin stimulates the energy metabolism in human platelets [PDF]

, 2017
Thrombin-induced platelet activation requires substantial amounts of ATP. However, the specific contribution of each ATP-generating pathway i.e., oxidative phosphorylation (OxPhos) versus glycolysis and the biochemical mechanisms involved in the thrombin-
A Archiche, A Ferreta, A Kasirer-Friede, A Lechi, A Marín-Hernández, AI Schafer, AJM Verhoeven, AM Amorini, AN Sveshnikova, AR Gear, Christian Schulz, D Banerjee, DA Slatter, E De Candia, E De Candia, F Adam, F Sinigaglia, G Solsau, GN Bijur, H Kilkson, HU Bergmeyer, I Fisher, I Hernández-Reséndiz, Ileana Hernández-Reséndiz, J Deprez, JRS Day, JW Akkerman, JY Jang, KS Authi, L Brass, LR Sorbara, M Baggiolini, Manuel Gutiérrez-Aguilar, MH Rider, MR Wardell, MY Shen, N Cardenes, N Corona de la Peña, NM Bressler, Norma Corona de la Peña, RA Nakashima, RL Elstrom, RM Denton, RW Moreadith, S Kim, S Offermans, S Ravi, S Rodríguez-Enríquez, S Zharikov, Sara Rodríguez-Enríquez, SI Obydennyy, T Sabo, V Vasta, Y Dobrydneva, Y Dobrydneva, ZP Shaik, Álvaro Marín-Hernández   +56 more
core   +3 more sources

SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19

Journal of Hematology & Oncology, 2020
Background Critically ill patients diagnosed with COVID-19 may develop a pro-thrombotic state that places them at a dramatically increased lethal risk. Although platelet activation is critical for thrombosis and is responsible for the thrombotic events ...
Shenmin Zhang, Yangyang Liu, Xiaofang Wang, Li Yang, Haishan Li, Yuyan Wang, Mengduan Liu, Xiaoyan Zhao, Youhua Xie, Yan Yang, Shenghui Zhang, Zhichao Fan, Jianzeng Dong, Zhenghong Yuan, Z. Ding, Yi Zhang, Liang Hu   +16 more
semanticscholar   +1 more source

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, EarlyView.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source