Results 71 to 80 of about 478,140 (363)

Platelet-Derived Inhibitors of Platelet Activation [PDF]

, 2017
Negative regulators of platelet activation are a relatively unexplored aspect of platelet physiology yet have an important role in tempering thrombus development by contributing much needed negative regulation to a process that is amplified by several positive feedback mechanisms.
Unsworth, AJ, Bye, AP, Gibbins, JM
openaire   +2 more sources

Acute cardiac inflammatory responses to postischemic reperfusion during cardiopulmonary bypass [PDF]

, 1999
Objectives: The investigation centers on whether there is a reperfusion-induced specific cardiac inflammatory reaction after bypass surgery. Background: Cardiopulmonary bypass (CPB) leads to systemic inflammation.
Becker, Bernhard F., Hartl, Heinz, Hähnel, Christoph, Massoudy, Parwis, Meisner, Hans, Zahler, Stefan   +5 more
core   +1 more source

Report on the 2nd MObility for Vesicle research in Europe (MOVE) symposium—2024

FEBS Open Bio, EarlyView.
The 2nd MObility for Vesicle research in Europe (MOVE) Symposium in Belgrade brought over 280 attendees from 28 countries to advance extracellular vesicle (EV) research. Featuring keynotes, presentations, and industry sessions, it covered EV biogenesis, biomarkers, therapies, and manufacturing.
Dorival Mendes Rodrigues‐Junior, Michaela Kocholata, Marilena E. Lekka, Olga Janouskova, Moran Yadid, Maja Kosanovic   +5 more
wiley   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Complement C3 inhibition reduces complement activation in clinical platelet concentrates but does not counteract platelet storage lesions

Platelets
Platelet storage is associated with storage lesions, including platelet morphological changes and a gradual functional loss. We investigated the impact of complement C3 inhibition on complement activation and platelet storage lesions in clinical platelet
Linnea I. Andersson, Per Sandgren, Dick J. Sjöström, Camilla Mohlin, Kim Hägerström, Ivar Tjernberg, Tom Eirik Mollnes, Per H. Nilsson   +7 more
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

The effects of arterial flow on platelet activation, thrombus growth, and stabilization [PDF]

, 2017
Injury of an arterial vessel wall acutely triggers a multifaceted process of thrombus formation, which is dictated by the high-shear flow conditions in the artery. In this overview, we describe how the classical concept of arterial thrombus formation and
Angelillo-Scherrer, Anne, Cosemans, Judith M.E.M., Heemskerk, Johan W.M., Mattheij, Nadine J.A.   +3 more
core  

Role of P-selectin in platelet sequestration in pulmonary capillaries during endotoxemia [PDF]

, 2006
Background: There is growing evidence that platelets accumulate in the lung and contribute to the pathogenesis of acute lung injury during endotoxemia.
Alwin Eduard Goetz, Barry BE, Bevilacqua MP, Body SC, Brunk DK, Deuel TF, Dore M, Feuerhake F, Forde RC, Frenette PS, Greenberg AW, Handa K, Hattori R, Heffner JE, Kai Heckel, Kiefmann R, Kubes P, Kubo H, Kuebler WM, Kuhnle GE, Kuhnle GE, Kuklin V, Leo R, Ley K, Li N, Martina Dörger, Massberg S, Matsui NM, Okada Y, Parish CR, Piccardoni P, Rainer Kiefmann, Rinko LJ, Rodgers SD, Ruf A, Sonja Schenkat, Wang L, Williams MJ   +37 more
core   +1 more source

Impact of Stress‐Induced Hyperglycemia on In‐Hospital Medical Complications in Patients With Acute Stroke: From a Large‐Scale Nationwide Longitudinal Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aims This study aimed to explore the relationship between stress‐induced hyperglycemia (SIH) and in‐hospital medical complications in patients with acute stroke. Methods We enrolled 865,765 patients with acute stroke from the Chinese Stroke Center Alliance cohort.
Xintong Song, Yi Ju, Hongqiu Gu, Zhikai Zhu, Zixiao Li, Qian Zhang, Xingquan Zhao   +6 more
wiley   +1 more source

Acetylsalicylic acid differentially limits the activation and expression of cell death markers in human platelets exposed to Staphylococcus aureus strains

Scientific Reports, 2017
Beyond their hemostatic functions, platelets alter their inflammatory response according to the bacterial stimulus. Staphylococcus aureus is associated with exacerbated inflammation and thrombocytopenia, which is associated with poor prognosis during ...
Adrien Chabert, Pauline Damien, Paul O. Verhoeven, Florence Grattard, Philippe Berthelot, Fabrice Zeni, Laurence Panicot-Dubois, Stéphane Robert, Françoise Dignat-George, Marie-Ange Eyraud, Bruno Pozzetto, Bernard Payrastre, Fabrice Cognasse, Olivier Garraud, Hind Hamzeh-Cognasse   +14 more
doaj   +1 more source