Results 231 to 240 of about 394,734 (292)

Controllable Cascade Aggregation Ion Programmed Nanomachines and Simple Isolation Enable Tumor‐Derived Small Extracellular Vesicles Detection for Enhanced Breast Cancer Assessment

Advanced Science, EarlyView.
This study developed a convenient, enzyme‐free detection platform based on controllable aggregation ion nanomachines. Its favorable anti‐interference capacity and high sensitivity meet the detection requirements for clinical samples processed via a simple filtration method within 10 min.
Zhihao Zhang, Zijing Liu, Xiangyue Meng, Pengjun Jiang, Jie Qu, Yu Jiang, Binxu Qiu, Jie Chen, Piaopiao Chen   +8 more
wiley   +1 more source

The CXCL5/CXCR2 Axis Attenuates Ferroptosis in Intrahepatic Cholangiocarcinoma Through the Positive Feedback Loop Between PTGS2 Transcriptional Activation and Neutrophil Recruitment

Advanced Science, EarlyView.
The CXCL5/CXCR2 axis directly inhibits ferroptosis in ICC cells by activating the NF‐κB/PTGS2 pathway. Meanwhile, the CXCL5/CXCR2 axis recruits N2 TANs, and the activated PTGS2 promotes the secretion of TNF‐α from the recruited N2 TANs via the CCL2/CCL7/CCR2 pathway, thereby activating the NF‐κB/PTGS2 axis and forming a positive feedback loop, which ...
Chanqi Ye, Kefeng Lin, Shuyao Yang, Yan Zhang, Wenli Gao, Jiaqi Chen, Ying Dong, Rui Bai, Yang Tian, Minghao Wang, Zhijun Yuan, Yuxiao Ma, Yuqin He, Ruyin Chen, Wenguang Fu, Qi Jiang, Qiong Li, Jian Ruan   +17 more
wiley   +1 more source

Encapsulated Leptin‐Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates

Advanced Science, EarlyView.
A clinically translatable cell line can be engineered to produce leptin, encapsulated in biomaterial and safely implanted to produce and deliver the metabolic regulating protein within the body. Implantation of these encapsulated cells decreases the time it takes for mice and non‐human primates to adjust to circadian disruptions similar to those ...
Samantha T. Fleury, Xuanyi Lin, Peter D. Rios, Christopher Olker, Eun Joo Song, Alejandra Cobos Perez, Cody Fell, Daisy Lopez, Ira Joshi, Hafsa Nasir, Cecelia Curtis, Danna Muringi, Kaiyuan Wang, José Oberholzer, Fred W. Turek, Isaac B. Hilton, Jonathan Rivnay, Martha Hotz Vitaterna, Omid Veiseh   +18 more
wiley   +1 more source

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Storage of Platelet Concentrates

Transfusion, 1976
The American National Red Cross has initiated a cooperative clinical study designed to evaluate the therapeutic effectiveness of fresh platelets and platelets stored at 4 or 22 C for up to 72 hours. Preliminary results, in confirmation of earlier work, indicate an inverse relationship between platelet count and bleeding time in patients with ...
R A, Kahn, H T, Meryman
openaire   +2 more sources

Quality of Platelet Concentrates

Immunological Investigations, 1995
Despite the current emphasis in transfusion medicine on regulatory compliance and cost containment, there is continuing activity in quality improvement of blood products. Quality can be assessed by measuring both benefit and risk. High quality products are those in which the benefit is maximized and the risk minimized.
J D, Sweeney, S, Holme, A, Heaton
openaire   +2 more sources

Aggregates in platelet concentrates

Vox Sanguinis, 2014
P. F. van der Meer, L. J. Dumont, M. Lozano, N. Bondar, J. Wong, S. Ismay, J. Pink, W. Nussbaumer, J. Coene, H. B. Feys, V. Compernolle, D. V. Devine, D. Howe, C. K. Lin, J. Sun, J. Ringwald, E. F. Strasser, R. Eckstein, A. Seltsam, P. Perseghin, P. Proserpio, S. Wakamoto, M. Akino, S. Takamoto, K. Tadokoro, D. Teo, P. H. Shu, S. S. Chua, T.
Pieter F, van der Meer, L J, Dumont, Miguel, Lozano, Noemi, Bondar, Janet, Wong, Sue, Ismay, Joanne, Pink, Walter, Nussbaumer, José, Coene, H B, Feys, Veerle, Compernolle, Dana V, Devine, David, Howe, Che Kit, Lin, Jenny, Sun, Juergen, Ringwald, Erwin F, Strasser, Reinhold, Eckstein, Axel, Seltsam, Paolo, Perseghin, Patrizia, Proserpio, Shinobu, Wakamoto, Mitsuaki, Akino, Shigeru, Takamoto, Kenji, Tadokoro, Diana, Teo, Pei Huey, Shu, Sze Sze, Chua, Teresa, Jimenez-Marco, Miguel, Lozano, Joan, Cid, Emma, Castro, Irene, Muñoz, Hans, Gulliksson, Per, Sandgren, Stephen, Thomas, Juraj, Petrik, Kevin, McColl, Hany, Kamel, James, Dugger, Joseph D, Sweeney, Jed B, Gorlin, Laurie J, Sutor, Doug, Heath, Merlyn H, Sayers   +44 more
openaire   +2 more sources

Platelet Activity in Washed Platelet Concentrates

Anesthesia & Analgesia, 2004
Life-threatening anaphylaxis or febrile nonhemolytic transfusion reactions after transfusion of platelet concentrates (PCs) is a serious clinical problem caused by the sensitizing of recipients to plasma components, such as immunoglobulin A, or by cytokines. There is a possible indication for washing of PCs in these thrombocytopenic patients.
Schoenfeld H, Muhm M, Doepfmer U, Exadaktylos A, Radtke H   +4 more
openaire   +3 more sources

Preparation of Platelet Concentrates

2011
Platelets are specialized blood cells that play central roles in physiologic and pathologic processes of hemostasis, wound healing, host defense, thrombosis, inflammation, and tumor metastasis. Activation of platelets is crucial for platelet function that includes a complex interplay of adhesion, signaling molecules, and release of bioactive factors ...
David W, Greening, Rosemary L, Sparrow, Richard J, Simpson   +2 more
openaire   +2 more sources

Effects of high platelet concentration in collecting and freezing dry platelets concentrates

Transfusion and Apheresis Science, 2004
To evaluate, in vitro, the effects of collecting and cryopreserving fresh dry platelet concentrates (PCs).Standard and dry PCs were collected in the same apheresis procedure. PCs were evaluated by mean platelet volume (MPV), pH, glucose and LDH levels.
Evaldo Pasquini, Landi, Eduardo Gasparotto, Roveri, Margareth Castro, Ozelo, Joyce Maria, Annichino-Bizzacchi, Andreia Fernanda, Origa, Aparecida Ribeiro, de Carvalho Reis, Cármino Antonio, de Souza, José Francisco Comenalli, Marques   +7 more
openaire   +2 more sources

Bacterial proliferation in platelet concentrates

Transfusion, 1986
ABSTRACT: Growth curves of bacteria in platelet concentrates were studied to determine whether increasing the shelf‐life of platelets from 3 to 7 days might have contributed to the increased number of deaths caused by contaminated platelets that have been reported to the FDA since 1980.
J M, Heal, S, Singal, E, Sardisco, T, Mayer   +3 more
openaire   +2 more sources