Results 71 to 80 of about 394,734 (292)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Separation, Concentration, and Transfusion of Platelets.

Experimental Biology and Medicine, 1951
Summary(1) A simple method is presented for the efficient separation and concentration of platelets from human, dog, and guinea pig blood in quantities sufficient for transfusion. (2) This method depends upon the use of Sequesterene Na2 as an anticoagulant, which prevents the development of platelet stickiness and clumping in shed blood.
Dillard, G. H. L., Brecher, G., Cronkite, E. P.   +2 more
openaire   +2 more sources

Role of P-selectin in platelet sequestration in pulmonary capillaries during endotoxemia [PDF]

, 2006
Background: There is growing evidence that platelets accumulate in the lung and contribute to the pathogenesis of acute lung injury during endotoxemia.
Schenkat, Sonja, Kiefmann, Rainer, Dörger, Martina, Goetz, Alwin Eduard, Heckel, Kai   +4 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Clinical outcome of platelet transfusion using platelet-rich plasma-derived platelets and buffy coat-removed platelets in patients with dengue fever – A comparison

Global Journal of Transfusion Medicine, 2020
Background and Objectives: Platelet transfusions are widely used to treat thrombocytopenia of various etiology. There are two different methods of preparation of platelet concentrate from whole blood: one is platelet-rich plasma method (PRP) and the ...
Jyothis Purushothaman, Susheela Jacob Innah   +1 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Platelet factor 4 in platelet concentrates.

Journal of the Japan Society of Blood Transfusion, 1984
The release of platelet factor 4 (PF4) from platelets in platelet concentrates (PC) were investigated sequentially in the process of blood collection, and their storage at room temperature for up to 72h with agitation. No appreciable increase in PF4 release was seen immediately after blood collection.
Ishikawa, Yuko, Shimizu, Tetsuo, Hibi, Satomi, Tsurumi, Hiromi, Goto, Soji, Hasegawa, Iwazo, Fukuda, Tsuneo, Kato, Kanefusa   +7 more
openaire   +2 more sources

Optic Disc Pit treated by Vitrectomy and Platelet Concentrate

After unsuccessful pretreatment with laser along the temporal circumference of the optic disc (old scars) a vitrectomy is performed, posterior vitreous separation and platelet concentrate. The idea of platelets is to clog the pig.
eyeMoviePedia gGmbH, Kirchhof, Bernd
core   +1 more source

Methylglyoxal induces platelet hyperaggregation and reduces thrombus stability by activating PKC and inhibiting PI3K/Akt pathway [PDF]

, 2013
Diabetes is characterized by a dysregulation of glucose homeostasis and platelets from patients with diabetes are known to be hyper-reactive and contribute to the accelerated development of vascular diseases.
Voahanginirina Randriamboavonjy, Ingrid Fleming, Amro Elgheznawy, Randriamboavonjy, Voahanginirina, Fleming, Ingrid, Amro Elgheznawy (458464), Karin Hadas, Hadas, Karin, Karin Hadas (458462), Alexander Mann (262817), Elgheznawy, Amro, Mann, Alexander, Ingrid Fleming (132865), Alexander Mann, Voahanginirina Randriamboavonjy (458463)   +14 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source