Results 41 to 50 of about 266,199 (261)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Evaluation of burn sepsis with reference to platelet count as a prognostic indicator

CHRISMED Journal of Health and Research, 2020
Background: Burn is the oldest form of injury to inflict humankind, and infection is a major challenge in the management of burn patients and is a leading cause of morbidity and mortality.
Surya Prakash, Chhaya Rani Shevra, Dwijendra Nath   +2 more
doaj   +1 more source

The clinical study of thromboelas-tography combined with coagulation four items and platelet count to guide platelet transfusion in critically ill patients

Zhongguo shuxue zazhi, 2022
Objective To explore the clinical value of thromboelas-tography, coagulation four items and platelet count in guiding platelet transfusion in critically ill patients.
Shuting JIANG, Lingxiao FENG, Jingli SHI, Tingting XU, Hui YAN, Beizhan YAN   +5 more
doaj   +1 more source

Advances in Platelet Counting

Hematology, 2001
Accurate and reliable platelet counting is critical for the clinical management of platelet disorders, especially in thrombocytopenia. The platelet count is used to determine if the patient requires a platelet transfusion. As the prophylactic transfusion trigger is now set anywhere between 10-20 × 10(9)/L (depending upon the institution) it is ...
P, Harrison, C, Briggs, S, Machin
openaire   +2 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Mean Platelet Volume and the Ratio of Mean Platelet Volume/Platelet Count in Acute Rheumatic Fever

Journal of Pediatric Research, 2021
Aim:Acute rheumatic fever (ARF) is an endemic disease especially in developing countries. Due to an autoimmune response to group B streptococcus throat infection, ARF develops in susceptible children. Mean platelet volume (MPV) reflects the platelet size
Dolunay Gürses, Funda Akpınar, Mustafa Doğan   +2 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Normal Value of Thrombocytes Indices in Indonesian Adults: Focus on Gender and Ages

Indonesian Biomedical Journal
BACKGROUND: Monitoring platelet count and related indices is crucial for managing hematological disorders. No studies are reporting normal platelet indices in the adult Indonesian population.
Usi Sukorini, Adika Zhulhi Arjana, Tri Ratnaningsih, Rahmat Dani Satria   +3 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Evaluation of the Efficacy of Lusutrombopag for Chronic Liver Disease Based on Pre‐Treatment Platelet Counts: A Retrospective Multicenter Study

JGH Open
Background Oral thrombopoietin receptor agonists are used to treat thrombocytopenia in patients with chronic liver disease who are scheduled for invasive procedures. The efficacy of lusutrombopag based on the pretreatment platelet count was investigated.
Takayoshi Suga, Satoru Kakizaki, Atsushi Naganuma, Takeshi Hatanaka, Satoshi Takakusagi, Daichi Takizawa, Hirotaka Arai, Takashi Ueno, Keisuke Iizuka, Toru Fukuchi, Shuichi Saito, Hiroki Tojima, Yuichi Yamazaki, Toshio Uraoka   +13 more
doaj   +1 more source