Results 71 to 80 of about 976,634 (303)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

THE EFFECTIVENESS OF PAPAYA LEAF EXTRACT (CARICA PAPAYA L.) AS AN ANTIAGGREGATION AGENT ON PLATELET COUNT AND PLATELET AGGREGATION: IN VITRO STUDY

Journal of Vocational Health Studies
Background: In hypertensive patients, platelet hyperaggregation may lead to acute ischemic stroke, which can increase mortality or neurological deficits.
Ganjar Noviar, Eem Hayati, Riski Nur Ramadhani   +2 more
doaj   +1 more source

A Look at Platelet Count in Chronic Hepatitis C Infection [PDF]

, 2017
A complete blood count performed in chronic hepatitis C virus (HCV) infected patients can identify thrombocytopenia or an increased number of platelets, the cause of which must be established.
Romeo-Gabriel Mihăilă
core  

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Platelet count and risk of major bleeding in venous thromboembolism

Platelets, 2021
The relationship between platelet count and risk of major bleeding in patients with venous thromboembolism (VTE) during anticoagulation remains unclear.
Håkon S. Johnsen, Sigrid K. Braekkan, Vânia M. Morelli, John-Bjarne Hansen   +3 more
doaj   +1 more source

Platelet count to predict the presence of gastroesophageal varices.

, 2021
Platelet count to predict the presence of gastroesophageal varices.
Akira Yamamoto (560236), Eiji Ehara (11534628), Tsugutoshi Suzuki (11534634), Atsushi Jogo (11534631), Yosuke Murakami (1743175), Yuga Amano-Teranishi (11534637), Daisuke Tokuhara (397283), Yoshiharu Isoura (11534625), Yuki Cho (799294), Kiyohide Kioka (11534640), Takashi Hamazaki (209801)   +10 more
core   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Associations of Platelet Count with Inflammation and Response to Anti-TNF-α Therapy in Patients with Ankylosing Spondylitis

Frontiers in Pharmacology, 2020
Background: Increased platelet count has been reported in ankylosing spondylitis (AS) patients, but its clinical significance is still largely elusive.
Hongyan Qian, Hongyan Qian, Rongjuan Chen, Rongjuan Chen, Bin Wang, Xiaoqing Yuan, Shiju Chen, Shiju Chen, Yuan Liu, Yuan Liu, Guixiu Shi, Guixiu Shi   +11 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Machine learning based prediction of platelet concentration from ROTEM measurements

Scientific Reports
Viscoelastic testing is an established standard in modern coagulation medicine, reducing transfusion needs. However, it does not provide direct information on platelet count.
Roxane Brooks, Matthias Noitz, Tina Tomić Mahečić, Diana Mühl, Ákos Kerekes, Gabor Nardai, Christa Kubasta, Mislav Kasalo, Mateja Ulamec, Alexander Maletzky, Janos Fazakas, Jens Meier   +11 more
doaj   +1 more source