Results 41 to 50 of about 45,160 (254)

Diagnostic value of platelet indices in COVID 19 infection: a case-control study from a single tertiary care center

The Egyptian Journal of Internal Medicine, 2022
Introduction Platelets are not only involved in hemostasis and coagulation, but play a significant role in innate immunity and inflammatory response.
Arundhathi Shankaralingappa, Santosh Tummidi, Thirunavukkarasu Arun Babu   +2 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Evaluation of Platelet Indices in Lung Cancer Patients [PDF]

Asian Pacific Journal of Cancer Prevention, 2015
In this study, we aimed to determine platelet indices such as platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), Plateletcrit (PCT) platelet count (PLT) in lung cancer cases, and evaluate any relationships between these parameters and stage or histologic types.This retrospective study covered 44 lung cancer patients ...
Öncel, Müfide, Kıyıcı, Aysel, Öncel, Murat, Sunam, Güven Sadi, Şahin, Emel, Adam, Bahattin   +5 more
openaire   +2 more sources

Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen, Wenting Huang, Yitian Liu, Xuan Chen, Buyu Ke, Qian Shen, Hanyu Cai, Jing Sun, Yan Li, Yungang Cao, Beilei Hu, Keyang Chen   +11 more
wiley   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications

Hematology, 2011
Diabetes mellitus (DM) has been considered as a 'prothrombotic state' with enhanced platelet reactivity. Mean platelet volume (MPV) has been evaluated in DM and correlated with retinopathy. This study was aimed at evaluating platelet indices in diabetic versus non-diabetic patients and assessing their utility as indicators of presence of complications ...
Sonali, Jindal, Shilpa, Gupta, Ruchika, Gupta, Ashima, Kakkar, Harsh V, Singh, Kusum, Gupta, Sompal, Singh   +6 more
openaire   +2 more sources

Utility of platelet count and platelet indices as a prognostic indicator in pregnancy induced hypertension

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2022
Background: Changes in the hemostatic system are observed in both normal and hypertensive pregnant patients. Although the exact pathophysiology of pregnancy induced hypertension is not completely understood, numerous pathophysiological mechanisms, alone or in combination, have been suggested to be responsible for the diverse subsets of PIH.Methods ...
Neha Saini, Roli Gautam, Shanti Jeyaseelan   +2 more
openaire   +1 more source

Evaluation of Platelet Parameters in Relation to Aspartate Aminotransferase to Platelet Ratio Index and Fibrosis-4 Scores among Non-alcoholic Fatty Liver Disease Patients and Healthy Controls: An Exploratory Study

Journal of Medical Evidence
Background: Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver condition closely linked with obesity and metabolic syndrome. Early detection of hepatic fibrosis is essential to prevent progression to cirrhosis.
Prachi Mishra, Sadhna Marwah, Vijay Kumar, Vaishali Bhardwaj, Tanvi Jha, Neha Singh   +5 more
doaj   +1 more source

Mimicking platelet indices in patients with malaria and dengue hemorrhagic fever: characteristics and clinical applications

Tropical Medicine and Health, 2022
Background Although platelet indices are routinely available using automated blood cell counters, the clinical applications of these parameters for malaria and dengue hemorrhagic fever (DHF) have not been substantially implemented.
Nant The Su Mon, Noppadon Tangpukdee, Prakaykaew Charunwatthana, Kobporn Boonnak, Srivicha Krudsood, Shigeyuki Kano, Polrat Wilairatana, Wattana Leowattana   +7 more
doaj   +1 more source