Results 71 to 80 of about 227,390 (256)

Platelet parameters and expression of platelet membrane glycoprotein in childhood acute lymphoblastic leukemia

Genetics and Molecular Research, 2015
Platelet activation and functional changes were investigated in acute lymphoblastic leukemia (ALL) to provide the basis for early diagnosis and evaluation of curative effect. Platelet parameters, immature platelet fraction (IPF%), immature platelet count (IPC), P-selectin (CD62p) (PAC-1) expression were detected in ALL, ALL-complete remission-induced ...
Z, Huang, W J, Liu, Q L, Guo, C Y, Liu
openaire   +2 more sources

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Can platelet yield be predicted before the donation in plateletpheresis? A study on the impact of donors’ and procedural parameters on platelet yield [PDF]

Journal of Medical and Life Science
Background: Platelet transfusion plays a critical role in thrombocytopenic patients. Platelet concentrate was prepared by using apheresis technique (SDP), and its efficacy as platelet yield was correlated with donors’ demographic variables.Objectives: To
Purti Saini, Sandeep Matreja, Kushpreet Kaur, Preeti Chakrabarti   +3 more
doaj   +1 more source

Anorectal Dysfunction in Systemic Sclerosis: Clinical Phenotypes and Functional Patterns

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to characterize specific physiologic defects in anorectal dysfunction in systemic sclerosis (SSc) using anorectal manometry (ARM), evaluate associations with gastrointestinal (GI) and extraintestinal clinical phenotypes, and explore potential serologic markers for risk stratification.
Timothy Kaniecki, Alireza Amindarolzarbi, Tsion Abdi, John Clarke, Michael Hughes, Ami A. Shah, Zsuzsanna H. McMahan   +6 more
wiley   +1 more source

Association of Elevated Platelets and C‐Reactive Protein With Severe Disease and Poor Survival in Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective Elevated C‐reactive protein (CRP) levels in systemic sclerosis (SSc) have been linked with severe disease and worse survival, but the role of platelet levels remains unclear. This study examined whether elevated platelet levels, CRP levels, or both are associated with disease severity, progression, and survival in SSc.
Brian S. Lee, Shufeng Li, Srijana Davuluri, Jennifer Lee, Lorinda Chung   +4 more
wiley   +1 more source

Reactive Thrombocytosis and Changes in Platelet Parameters in Children with Iron Deficiency Anaemia: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Iron Deficiency Anaemia (IDA) is the most common type of anaemia in paediatric age group. IDA has reported to be associated with thrombotic complications such as fatal cerebrovascular thrombosis, central retinal vein thrombosis, suggesting ...
Payal Agrawal, Priyamvada Singh, Nitesh Singla, Ankit Agrawal   +3 more
doaj   +1 more source

Impact of Six‐Month Monitoring Compared to Three‐Month Monitoring of Laboratories During Methotrexate Therapy

Arthritis Care &Research, EarlyView.
Objective To evaluate whether extending the American College of Rheumatology–recommended monitoring interval for complete blood count and liver function tests in patients receiving methotrexate (MTX) affects timely detection of medication‐related toxicity.
Spencer Simko, Ray Zhang, Sohini Mukherjee, Puneet Bajaj, Bonnie L. Bermas   +4 more
wiley   +1 more source

Light‐Assisted 3D Printing Techniques and Photocrosslinking Strategies: Recent Advances in Musculoskeletal Tissue Engineering

Advanced Engineering Materials, EarlyView.
In this review, the current state of light‐assisted 3D printing as it pertains to engineering musculoskeletal tissues including bone, cartilage, skeletal muscle, tendon, and ligaments is summarized. Common printing techniques, photoreactive materials, and study design choices are compiled and reviewed.
Meagan Morgan, Bin Zhang, Roger Narayan
wiley   +1 more source

Karl Popper and the Mechanisms of Hydrogen Embrittlement

Advanced Engineering Materials, EarlyView.
Representation of the beginning of loss of ductility rather than embrittlement. Small concentrations of hydrogen in a diffusible form within iron are well‐established to harm the mechanical integrity of steels. There are theories that attempt to explain the pernicious role of hydrogen.
H. K. D. H. Bhadeshia
wiley   +1 more source

Haemostatic parameters, platelet activation markers, and platelet indices among regular plateletpheresis donors

Journal of Taibah University Medical Sciences, 2018
الملخص: أهداف البحث: يعتبر فصل صفائح الدم لإعدادها للتبرع إجراءً آمنا، بصورة عامة. وهناك دراسات محدودة عن تأثيرها على معلمات تخثر الدم، واحتمال وجود ارتباط بين الفصل الآلي للصفائح الدموية وحالة فرط التخثر.
Hulwani T.M. Tuan, MPath (Haematology), Lim S. Hock, MSc, Zaidah W. Abdullah, MPath (Haematology)   +2 more
doaj   +1 more source