Results 21 to 30 of about 96,906 (352)

Circulating microRNAs as biomarkers and mediators of platelet activation

Platelets, 2022
Platelets are essential mediators of physiological hemostasis and pathological thrombosis. Currently available tests and markers of platelet activation did not prove successful in guiding treatment decisions for patients with cardiovascular disease ...
Clemens Gutmann, Manuel Mayr
doaj   +1 more source

The relationship between fractional flow reserve, platelet reactivity and platelet leukocyte complexes in stable coronary artery disease. [PDF]

PLoS ONE, 2013
BACKGROUND: The presence of stenoses that significantly impair blood flow and cause myocardial ischemia negatively affects prognosis of patients with stable coronary artery disease.
Jan-Willem E M Sels, Bert Rutten, Thijs C van Holten, Marieke A K Hillaert, Johannes Waltenberger, Nico H J Pijls, Gerard Pasterkamp, Philip G de Groot, Mark Roest   +8 more
doaj   +1 more source

Unfavorable Changes of Platelet Reactivity on Clopidogrel Therapy Assessed by Impedance Aggregometry Affect a Larger Volume of Acute Ischemic Lesions in Stroke

Diagnostics, 2021
Background: High on-treatment platelet reactivity or its equivalent—resistance to the antiplatelet agent—significantly reduces the efficacy of the therapy, contributing to a negative impact on stroke course.
Adam Wiśniewski, Joanna Sikora, Aleksandra Karczmarska-Wódzka, Przemysław Sobczak, Adam Lemanowicz, Elżbieta Zawada, Rytis Masiliūnas, Dalius Jatužis   +7 more
doaj   +1 more source

Biologic Nanoparticles and Platelet Reactivity [PDF]

Nanomedicine, 2009
Nanosized particles (NPs) enriched in hydroxyapatite and protein isolated from calcified human tissue accelerate occlusion of endothelium-denuded arteries when injected intravenously into rabbits. Since platelet aggregation and secretory processes participate in normal hemostasis, thrombosis and vascular remodeling, experiments were designed to ...
Kevin Chu, Phillip D Squillace, John C. Lieske, Larry W. Hunter, Muthuvel Jayachandran, Vivasvat Kaul, Virginia M. Miller   +6 more
openaire   +3 more sources

Platelet reactivity expressed as a novel platelet reactivity score is associated with higher inflammatory state after coronary artery bypass grafting

Archives of Medical Science, 2019
Introduction Despite therapy, patients operated using a cardiopulmonary bypass demonstrate increased platelet aggregation, which rebounds to above preoperative levels.
Mirosław Wilczyński, Michał Krejca, Piotr Stepinski, Marcin Rozalski, Jacek Golanski   +4 more
doaj   +1 more source

Is platelet inhibition due to thienopyridines increased in elderly patients, in patients with previous stroke and patients with low body weight as a possible explanation of an increased bleeding risk? [PDF]

, 2011
Background The TRITON-TIMI 38 study has identified three subgroups of patients with a higher risk of bleeding during treatment with the thienopyridine prasugrel: patients with a history of stroke or transient ischaemic attack (TIA), patients ≥75 years ...
C Combescure, D Sibbing, D Sibbing, DL Bhatt, DS Small, GW Stone, JW Werkum van, JW Werkum van, L Bonello, L Bonello, M Franchini, NJ Breet, OA Mokhtar, PA Gurbel, R Marcucci, S Matetzky, S Yusuf, SD Wiviott, SD Wiviott, SR Mehta, SR Steinhubl, T Cuisset, T Geisler   +22 more
core   +5 more sources

PrasugRel versus adjusted high-dose clopidogrel in patients with high on- clopidogrel platelet reactivity: the PECS-HPR randomized, multicenter study [PDF]

, 2015
background: Repeated loading doses (LD) of clopidogrel were shown to effectively overcome high on-clopidogrel platelet reactivity (HPR); however, comparison to potent P2Y12-inhibitors is lacking.
Aradi, Dániel
core   +1 more source

On-Clopidogrel Platelet Reactivity

Journal of the American College of Cardiology, 2011
Clopidogrel blocks the P2Y12 adenosine diphosphate receptor on platelets and, when given in addition to aspirin, has been shown to reduce cardiovascular events in patients with acute coronary syndromes (ACS) ([1,2][1]).
Stephen D. Wiviott, Willibald Hochholzer
openaire   +3 more sources

High Platelet Reactivity in Patients with Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention: Randomised Controlled Trial Comparing Prasugrel and Clopidogrel.

PLoS ONE, 2015
BackgroundPrasugrel is more effective than clopidogrel in reducing platelet aggregation in acute coronary syndromes. Data available on prasugrel reloading in clopidogrel treated patients with high residual platelet reactivity (HRPR) i.e. poor responders,
Tobias Geisler, Jean Booth, Elli Tavlaki, Athanasios Karathanos, Karin Müller, Michal Droppa, Meinrad Gawaz, Monica Yanez-Lopez, Simon J Davidson, Rod H Stables, Winston Banya, Azfar Zaman, Marcus Flather, Miles Dalby, Miles Dalby   +14 more
doaj   +1 more source

High platelet reactivity is a predictor of left ventricular remodelling in patients with acute myocardial infarction

ESC Heart Failure, 2022
Aims Acute myocardial infarction (AMI) is associated with left ventricular remodelling (LVR), which leads to progressive heart failure. Platelets play a pivotal role in promoting systemic and cardiac inflammatory responses during the complex process of ...
Masahiro Tsuji, Yusuke Kawai, Toru Miyoshi, Eisuke Saito, Kohei Kawamura, Tamaki Ono, Koji Tokioka, Tohru Ohe, Kazufumi Nakamura, Hiroshi Ito   +9 more
doaj   +1 more source