Pharmacodynamic Effect of Clopidogrel in Patients Undergoing Transcatheter Aortic Valve Implantation [PDF]
, 2013 The aim of this study was to analyze periprocedural and mid-term effect of clopidogrel on platelet function using the VerifyNow P2Y12 point-of-care assay in patients undergoing TAVI.
Frantisek Bednar +5 more
core +2 more sources
Effect of gender difference on platelet reactivity [PDF]
Netherlands Heart Journal, 2011 Previous studies have suggested that women do not accrue equal therapeutic benefit from antiplatelet medication as compared with men. The physiological mechanism and clinical implications behind this gender disparity have yet to be established.On-treatment platelet reactivity was determined in 717 men and 234 women on dual antiplatelet therapy ...
J. M. ten Berg +9 more
openaire +4 more sources
The genetics of normal platelet reactivity
Blood, 2010 AbstractGenetic and environmental factors contribute to a substantial variation in platelet function seen among normal persons. Candidate gene association studies represent a valiant effort to define the genetic component in an era where genetic tools were limited, but the single nucleotide polymorphisms identified in those studies need to be validated
Diane J. Nugent, Thomas J. Kunicki
openaire +4 more sources
Novel Strategies for Assessing Platelet Reactivity [PDF]
Future Cardiology, 2016 There are many approaches to assessing platelet reactivity and many uses for such measurements. Initially, measurements were based on the ability of platelets separated from other blood cells to aggregate together following activation with an appropriate 'aggregating agent'.
Algahtani, Mohammad, Heptinstall, Stan
openaire +4 more sources
Efficacy of cilostazol on platelet reactivity and cardiovascular outcomes in patients undergoing percutaneous coronary intervention: insights from a meta-analysis of randomised trials [PDF]
, 2014 Background: Cilostazol overcomes high on-treatment platelet reactivity (HTPR) and reduces adverse cardiovascular (CV) outcomes after percutaneous coronary intervention (PCI).
Bangalore, Sripal +6 more
core +1 more source
Platelet Receptor Proteolysis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2007 The platelet plasma membrane is literally at the cutting-edge of recent research into proteolytic regulation of the function and surface expression of platelet receptors, revealing new mechanisms for how the thrombotic propensity of platelets is controlled in health and disease.
Andrews, Robert K. +3 more
openaire +4 more sources
Dynamic platelet function: A novel biomarker in inflammatory arthritis?
PLoS ONE, 2022 Background Patients with inflammatory arthritis die prematurely of cardiovascular disease. Inflammation activates platelets. Since treatment of inflammatory arthritis is associated with reduced mortality, and decreased platelet reactivity reduces ...
Eithne Nic an Riogh +6 more
doaj +2 more sources
Gender-based differences in platelet function and platelet reactivity to P2Y12 inhibitors.
PLoS ONE, 2019 BACKGROUND:Gender influences platelet biology. Women have a larger platelet count, but gender-based differences in platelet function remain debated.
Marco Ranucci +6 more
doaj +1 more source
Serotonin reuptake inhibitors and cardiovascular disease [PDF]
, 2005 Selective serotonin re-uptake inhibiting drugs (SSRIs) are widely used for endogenous depression. In addition to depleting the nerve terminals of serotonin they also lower blood platelet serotonin levels.
Belcher, P.R. +2 more
core +1 more source
Impaired platelet reactivity in patients with septic shock: a proof-of-concept study
Platelets, 2020 Coagulation disorders and thrombocytopenia are common in patients with septic shock, but only few studies have focused on platelet variables beyond platelet count. The aim of this study was to evaluate whether platelets reactivity predicts sepsis-induced
Alberto Fogagnolo +10 more
doaj +1 more source