Results 41 to 50 of about 102,294 (349)

Impaired platelet reactivity in patients with septic shock: a proof-of-concept study

Platelets, 2020
Coagulation disorders and thrombocytopenia are common in patients with septic shock, but only few studies have focused on platelet variables beyond platelet count. The aim of this study was to evaluate whether platelets reactivity predicts sepsis-induced
Alberto Fogagnolo, Fabio Silvio Taccone, Gianluca Campo, Giacomo Montanari, Beatrice Capatti, Gioconda Ferraro, Andrea Erriquez, Riccardo Ragazzi, Jacques Creteur, Carlo Alberto Volta, Savino Spadaro   +10 more
doaj   +1 more source

Similar Inflammatory Biomarkers Reflect Different Platelet Reactivity in Percutaneous Coronary Intervention Patients Treated With Clopidogrel: A Large-Sample Study From China

Frontiers in Cardiovascular Medicine, 2021
Background: Platelet reactivity is closely associated with adverse events in percutaneous coronary intervention (PCI) patients. Inflammation plays a crucial role in the development of coronary heart disease (CHD).Aim: To investigate the association of ...
Jiawen Li, Deshan Yuan, Lin Jiang, Xiaofang Tang, Jingjing Xu, Ying Song, Jue Chen, Shubin Qiao, Yuejin Yang, Runlin Gao, Bo Xu, Jinqing Yuan, Xueyan Zhao   +12 more
doaj   +1 more source

Assessing a 600-mg Loading Dose of Clopidogrel 24 Hours Prior to Pipeline Embolization Device Treatment [PDF]

, 2018
Background: Clopidogrel/aspirin antiplatelet therapy routinely is administered 7-10 days before pipeline aneurysm treatment. Our study assessed the safety and efficacy of a 600-mg loading dose of clopidogrel 24 hours before Pipeline Embolization Device ...
Atallah, MD, Elias, Bekelis, MD, Kimon, Chalouhi, MD, Nohra, Hasan, MD, David, Jabbour, Pascal, MD, Rosenwasser, MD, MBA, FACS, FAHA, Robert H., Saad, MD, Hassan, Smith, MD, Michelle, Tjoumakaris, MD, Stavropoula, Zarzour, MD, Hekmat   +9 more
core   +2 more sources

Prostacyclin analogues decrease platelet aggregation but have no effect on thrombin generation, fibrin clot structure, and fibrinolysis in pulmonary arterial hypertension: PAPAYA coagulation

Platelets, 2022
Prostacyclin (PGI2) analogues (epoprostenol, treprostonil, iloprost) are the cornerstone of pulmonary arterial hypertension (PAH) treatment. PGI2 analogues inhibit platelet reactivity, but their impact on coagulation and fibrinolysis parameters has not ...
Aleksander Siniarski, Aleksandra Gąsecka, Miłosz Starczyński, Marta Banaszkiewicz, Szymon Darocha, Adam Torbicki, Marcin Kurzyna, Krzysztof J. Filipiak, Jadwiga Nessler, Grzegorz Gajos   +9 more
doaj   +1 more source

Clinical Implications of “Tailored” Antiplatelet Therapy in Patients With Chronic Total Occlusion

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Clopidogrel nonresponsiveness is a prognostic marker after percutaneous coronary intervention. Prasugrel and ticagrelor provide a better platelet inhibition and represent the first‐line antiplatelet treatment in acute coronary syndrome.
Maria Grazia De Gregorio, Rossella Marcucci, Angela Migliorini, Anna Maria Gori, Betti Giusti, Ruben Vergara, Rita Paniccia, Nazario Carrabba, Niccolò Marchionni, Renato Valenti   +9 more
doaj   +1 more source

Brolucizumab and Platelet Activation and Reactivity [PDF]

Current Eye Research
This study explores the potential interaction of brolucizumab with platelets and its effects on platelet activation and reactivity, crucial in retinal vasculitis and retinal vascular occlusion. Safety concerns remain of interest, although brolucizumab showed superior retinal efficacy and reduced injection frequency compared to other licensed anti-VEGF ...
B. Sobolewska, S. Poeschel, H. Kalbacher, K. Bieber, A. M. Paczulla Stanger, Konstantinos Stellos, F. Ziemssen   +6 more
openaire   +3 more sources

A hopeful therapy for Niemann-Pick C diseases [PDF]

, 2017
Not abstract ...
Erickson, Robert P., Fiorenza, Maria Teresa   +1 more
core   +1 more source

Systematic review and meta-analysis of optimal P2Y₁₂ blockade in dual antiplatelet therapy for patients with diabetes with acute coronary syndrome [PDF]

, 2016
Background: Patients with diabetes are at increased risk of acute coronary syndromes (ACS) and their mortality and morbidity outcomes are significantly worse following ACS events, independent of other comorbidities.
Brown, Oliver I, Hoye, Angela, Rossington, Jennifer A   +2 more
core   +1 more source

Clinical utility of remote platelet function measurement using P-selectin: assessment of aspirin, clopidogrel, and prasugrel and bleeding disorders [PDF]

, 2018
Vascular diseases such as myocardial infarction and ischemic stroke are associated with increased platelet function whilst the risk of recurrence is reduced by antiplatelet agents such as aspirin, clopidogrel, and prasugrel.
Adamany J, Bath PM, May J, Flaherty K, Woodhouse LJ, Dovlatova N, Fox SC, England TJ, Krishnan K, Robinson TG, Sprigg N, et al., Bath PM, Woodhouse LJ, Appleton JP, Beridze M, Christensen H, Dineen RA, Duley L, England TJ, Flaherty K, Havard D, et al., Cardoso RN, Benjo AM, DiNicolantonio JJ, Garcia DC, Macedo FY, El-Hayek G, Nadkarni GN, Gili S, Iannaccone M, Konstantinidis I, et al., Dovlatova N, Fox SC, May JA, Dovlatova N, Glenn JR, Johnson A, White AE, Radhakrishnan A, Heptinstall S., Heptinstall S, Heptinstall S, Heptinstall S, Jane May, Laohathai P, Joshi R, Radhakrishnan A, May J, Dovlatova N, Heptinstall S, Fox S., May J, Philip M Bath, Stan Heptinstall, TARDIS Trial Investigators, Krishnan K, Beridze M, Christensen H, Dineen R, Duley L, Heptinstall S, James M, Markus H, Pocock S, et al., Vlachojannis G   +15 more
core   +2 more sources

Head to Head Comparison of Two Point-of-care Platelet Function Tests Used for Assessment of On-clopidogrel Platelet Reactivity in Chinese Acute Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention

Chinese Medical Journal, 2016
Background: Platelet function tests are widely used in clinical practice to guide personalized antiplatelet therapy. In China, the thromboelastography (TEG) test has been well accepted in clinics, whereas VerifyNow, mainly used for scientific research ...
Yi Yao, Jia-Hui Zhang, Xiao-Fang Tang, Chen He, Yuan-Liang Ma, Jing-Jing Xu, Ying Song, Ru Liu, Xian-Min Meng, Lei Song, Miao Wang, Run-Lin Gao, Jin-Qing Yuan   +12 more
doaj   +1 more source