Results 61 to 70 of about 206,755 (278)

Platelet refractoriness – practical approaches and ongoing dilemmas in patient management

, 2015
Platelet refractoriness can represent a significant clinical problem that complicates the provision of platelet transfusions, is associated with adverse clinical outcomes and increases health care costs.
Judith Marsh, Simon J. Stanworth, Cristina Navarrete, Stanworth, Simon J., Marsh, Judith, Lise Estcourt, Navarrete, Cristina, Estcourt, Lise   +7 more
core   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

Current trends in platelet transfusions practice: The role of ABO-RhD and human leukocyte antigen incompatibility

Asian Journal of Transfusion Science, 2015
Platelet transfusions have contributed to the revolutionary modern treatment of hypoproliferative thrombocytopenia. Despite the long-term application of platelet transfusion in therapeutics, all aspects of their optimal use (i.e., in cases of ABO and/or ...
Serena Valsami, Dimitrios Dimitroulis, Argyri Gialeraki, Maria Chimonidou, Marianna Politou   +4 more
doaj   +1 more source

Yoda1‐Functionalized Nanozymes Coordinate Piezo1 Activation and Mitochondrial Protection to Reprogram the Diabetic Osteoimmune Micromilieu and Promote Vascularized Bone Repair

Advanced Science, EarlyView.
Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng, Ang Wang, Ren Zhang, Xu‐Ran Li, Po‐Lin Liu, Shu‐Hang He, Zi‐Yin Han, Zhi‐Han Shen, Zhan‐Ying Wei, Chang‐Ru Zhang, Fei Wang, Helen Dawes, Jian Lu, Tong‐He Zhu, Jin‐Zhong Zhao, Shang‐Chun Guo, Shi‐Cong Tao   +16 more
wiley   +1 more source

Platelet Transfusion Refractoriness

, 2013
Platelet transfusion has been used for decades as a highly beneficial therapeutic measure to prevent or stop bleeding in patients with severe thrombocytopenia by increasing the circulatory platelet numbers.
Mortazavi, Reza; id_orcid
core   +1 more source

Determination in vivo viability of a transfused platelet product by corrected count increment and percentage platelet response

The Pan African Medical Journal, 2017
INTRODUCTION: For many years, platelet concentrates have been used for the prevention as well as treatment of bleeding disorders, especially in those patients with haematological problems involving platelet disorders as well as refractoriness, In ...
Nancy Wanjiru Thuku, Kibet Shikuku, Amos Mbugua   +2 more
doaj   +1 more source

Leukofiltration plus pathogen reduction prevents alloimmune platelet refractoriness in a dog transfusion model

, 2017
Key Points Eight weekly transfusions of F-LR + pathogen-reduced donor platelets were accepted by 31 of 32 (97%) recipient dogs. Among accepting recipients, none developed lymphocyte and only 2 had platelet antibodies not associated with ...
S. Lawrence Bailey, Todd Christoffel, Sherrill J. Slichter, Irena Gettinger, Karen Nelson, Lakshmi Gaur, Doug Bolgiano, Esther Pellham, Yvette Latchman   +8 more
core   +1 more source

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

Advanced Science, EarlyView.
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Yechao Shen, Zhenguo Cao, Zenan Wang, Liang Chen, Jiahao Zhang, Linjie Zeng, Boren Tan, Hengyuan Li, Jiashan Lai, Jiangchu Lei, Fanglu Chen, Peng Lin, Zhenxuan Shao, Zhan Wang   +13 more
wiley   +1 more source

Platelet desialylation, apoptosis, and T-lymphocyte-mediated immune dysregulation: unveiling the pathways of platelet clearance in platelet transfusion refractoriness. [PDF]

Res Pract Thromb Haemost
Background: Platelet transfusion refractoriness (PTR) is a clinical challenge that can be classified into nonimmunologic and immunologic types, the latter resulting from both platelet alloimmunization and autoimmunity.
Zhou Y, Zhong Z, Mo H, Liang L, Su C, Chen Y, Lu F, Huang Y, Wu G.   +8 more
europepmc   +2 more sources