Results 101 to 110 of about 103,858 (377)

Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives

American Journal of Hematology, EarlyView.
ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
wiley   +1 more source

German guideline diverticular disease/diverticulitis

United European Gastroenterology Journal, Volume 10, Issue 9, Page 923-939, November 2022., 2022
Abstract Diverticulosis and diverticular disease are ranked among the most common gastroenterological diseases and conditions. While for many years diverticulitis was found to be mainly an event occurring in the elder population, more recent work in epidemiology demonstrates increasing frequency in younger subjects.
Wolfgang Kruis, Christoph‐Thomas Germer, Stephan Böhm, Franz L. Dumoulin, Thomas Frieling, Jochen Hampe, Jutta Keller, Martin E. Kreis, Alexander Meining, Joachim Labenz, Johann F. Lock, Jörg P. Ritz, Andreas Schreyer, Ludger Leifeld, for the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS) and the German Society of General and Visceral Surgery (DGAV) (AWMF‐Register 021‐20)   +15 more
wiley   +1 more source

Transmission matrix of a uniaxial optically active crystal platelet [PDF]

, 2005
Expressions corresponding to the transmission of a uniaxial optically active crystal platelet are provided for an optical axis parallel and perpendicular to the plane of interface. The optical activity is taken into account by a consistent multipolar expansion of the crystal medium response due to the path of an electromagnetic wave. Numerical examples
arxiv   +1 more source

Allogeneic Stem Cell Transplant for Myelofibrosis and Myelodysplastic Syndromes: A Contemporary Review

American Journal of Hematology, EarlyView.
ABSTRACT Allogeneic hematopoietic stem‐cell transplantation (HCT) remains the only potentially curative therapy for patients with myelodysplastic neoplasms (MDS) and myelofibrosis (MF) and is the standard care for eligible patients with higher‐risk disease. Despite significant advancements, both diseases pose unique challenges due to their clinical and
Nico Gagelmann, Nicolaus Kröger
wiley   +1 more source

Topics of Interest in Women With Myeloproliferative Neoplasms

American Journal of Hematology, EarlyView.
Women with MPN: life‐cycle phases, specific risks, and influencing factors. ABSTRACT Overview Sex and gender have emerged as central modifiers of disease biology, phenotype, and clinical outcomes in myeloproliferative neoplasms (MPNs). This review will uniquely highlight issues affecting women with MPN and articulate their relevant determinants ...
Natasha Szuber, Paola Guglielmelli, Naseema Gangat   +2 more
wiley   +1 more source

Robust Meta-Model for Predicting the Need for Blood Transfusion in Non-traumatic ICU Patients [PDF]

Objective: Blood transfusions, crucial in managing anemia and coagulopathy in ICU settings, require accurate prediction for effective resource allocation and patient risk assessment. However, existing clinical decision support systems have primarily targeted a particular patient demographic with unique medical conditions and focused on a single type of
arxiv   +1 more source

Assessment of therapeutic platelet transfusion effectiveness in thrombocytopenic hospitalized patients in hematology unit of Emam Khomeini Hospital [PDF]

Introduction: The platelets and the endothelium plays a major role in process of hemodynamic homeostasis. According to references, the recommended dose of platelets in thrombocytopenic patient is 1 unit per 10 kg body weight, and each unit anticipated to
اصدقی, زهرا, فروزانفر, محمد, پیرزاده, اصغر   +2 more
core  

The effect of variation in donor platelet function on transfusion outcome: A semi-randomised controlled trial [PDF]

, 2017
The effect of variation in platelet function in platelet donors on patient outcome following platelet transfusion is unknown. This trial assessed the hypothesis that platelets collected from donors with highly responsive platelets to agonists in vitro ...
Bakrania, L, Cardigan, RA, Deary, A, Foukaneli, T, Garner, SF, Godec, TR, Herbert, NL, Kahan, BC, Kelly, AM, Llewelyn, C, Ouwehand, WH, Williamson, LM   +11 more
core   +1 more source

Severe myelosuppression and alopecia after thiopurine initiation in a patient with NUDT15 deficiency

British Journal of Clinical Pharmacology, EarlyView.
Thiopurines are a class of immunosuppressant and antineoplastic agents. They are widely used in the treatment of inflammatory bowel disease, haematological malignancies and autoimmune diseases, but can cause significant toxicity. Inherited gene mutations are now recognized as independent risk factors for severe adverse drug reactions to thiopurines ...
Annie Siyu Wu, Lee Mozessohn, Richard B. Kim, Jonathan S. Zipursky   +3 more
wiley   +1 more source

Neonatal Thrombocytopenia: Diagnostic Approach and Platelet Transfusion Guideline

Clinical Pediatric Hematology-Oncology, 2019
Neonatal thrombocytopenia, defined as platelet counts of less than 150,000/µL, is a frequent hematologic abnormality in neonatal period. Differential diagnosis of neonatal thrombocytopenia may be challenging to pediatric hematologists and neonatologists ...
Ji Sook Kim, Ji Yoon Kim
doaj   +1 more source