Results 91 to 100 of about 374,751 (237)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Experimental Investigation of Various Type Absorber Plates for Solar
Journal of Agricultural Sciences, 2015 In this study, four different types’ absorber plates were designed and compared of their energetic performances. These absorber plates were formed as a flat plate (Type I), V-shaped (Type II), wedge-shaped (Type III) and wavy-shaped (Type IV).
Can Ertekin +2 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
On the effective shear modulus of composite honeycomb sandwich panels [PDF]
Scientific Technical Review, 2016 In the presented paper the effective shear modulus of composite plates with honeycomb core is determined. This elastic coefficient represents one very important property, especially in constructions subjected to torsion and combined bending - torsion ...
Rebhi Lamine +4 more
doaj
Nonlinear postbuckling of eccentrically stiffened functionally graded plates and shallow shells
Vietnam Journal of Mechanics, 2011 The paper deals with the formulation of governing equations of eccentrically stiffened functionally graded plates and shallow shells based upon the classical shell theory and the smeared stiffeners technique taking into account geometrical nonlinearity ...
Dao Huy Bich +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Buckling of stepped thickness plates in the theory of plasticity [PDF]
FME Transactions, 2011 The problem of buckling has been treated for a long time as a single rectangular field with different boundary conditions loaded with inplate loads and usually applying Levy method, when two opposite edges were always simply supported.
Dunjić Momčilo
doaj
Emu - Austral Ornithology, 1903 (Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Large deformations of thin plates subjected to impulsive loading [PDF]
, 1987 Includes bibliographical references.The dynamic response of structures subjected to blast and impact loading has been obtained relatively simply using rigid-plastic or rigid-viscoplastic material idealisations.
Nurick, Gerald N
core +1 more source