Results 81 to 90 of about 3,016,933 (291)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Transformation cloaking and radial approximations for flexural waves in elastic plates
New Journal of Physics, 2014 It is known that design of elastic cloaks is much more challenging than that of acoustic cloaks, cloaks of electromagnetic waves or scalar problems of anti-plane shear.
M Brun +4 more
doaj +1 more source
Вестник Дагестанского государственного технического университета: Технические науки, 2019 Objectives. The finite element method for cracked reinforced concrete slabs analysis after they were reinforced with composite fabrics in order to determine the residual safety factor is considered. Method.
V. P. Agapov, K. R. Aydemirov
doaj +1 more source
No quantum friction between uniformly moving plates
, 2009 The Casimir forces between two plates moving parallel to each other are found by calculating the vacuum electromagnetic stress tensor. The perpendicular force between the plates is modified by the motion but there is no lateral force on the plates ...
Leonhardt, U., Philbin, T. G.
core +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
THE BOOK BY G.R. FOULGER: FROM MELTING ANOMALIES TO HYPOTHESES ON PLATES OR PLUMES?
Геодинамика и тектонофизика, 2015 The book «Plates vs. plumes: a geological controversy» (Fig. 1) is intended for the advanced student who is not satisfied by the presentday interpretation of intraplate volcanism.
Sergei V. Rasskazov
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source