Results 81 to 90 of about 374,751 (237)
Compressive modulus of adhesive bonded rubber block [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2008 The present study examined the effect of a thin adhesive layer on the modulus of an elastic rubber block bonded between two plates. The plates were assumed to be rigid, both in extension and flexure, and subjected to vertical compression loading.
Wiriya Thongruang +1 more
doaj
Computing second-order scattering of obtuse dihedral for any incident angle
The Journal of Engineering, 2019 In this study, the second-order scattering area and field of obtuse dihedral is derived in detail. The obtuse angle, interior angle of dihedral, breaks the symmetry of the two plates in some extent, thus making the illumination case of double bounce more
Haibo Song, Gongjian Wen
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Influence of Applied Loads on Free Vibrations of Functionally Graded Material Plate–Shell Panels
Applied SciencesAn analysis of the influence of applied loads on free vibrations of plate and shell panels made of functionally graded materials is analyzed in the present work.
José Simões Moita +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
MathematicsThe solution of the nonlinear (NL) vibration problem of the interaction of laminated plates made of exponentially graded orthotropic layers (EGOLs) with elastic foundations within the Kirchhoff–Love theory (KLT) is developed using the modified Lindstedt ...
Mahmure Avey +3 more
doaj +1 more source
Revista Facultad de Ingeniería Universidad de Antioquia, 2015 The accuracy of the Boundary Element Method (BEM) is strongly dependent on an accurate evaluation of boundary integrals. For thin-walled structures, collocation points and integration elements are often very close, making the kernel of the integrations ...
Marco Antonio González De León +2 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source