Results 61 to 70 of about 3,016,933 (291)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Demonstration of an optical polarization magnifier with low birefringence
, 2004 In any polarimetric measurement technique, enhancing the laser polarization change of a laser beam before it reaches the analyzer can help in improving the sensitivity. This can be performed using an optical component having a large linear dichroism, the
Azzam R. M. A. +9 more
core +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Revista Facultad de Ingeniería Universidad de Antioquia, 2015 The accuracy of the Boundary Element Method (BEM) is strongly dependent on an accurate evaluation of boundary integrals. For thin-walled structures, collocation points and integration elements are often very close, making the kernel of the integrations ...
Marco Antonio González De León +2 more
doaj +1 more source
Journal of Clinical Orthopaedics and Trauma, 2013 Fracture shaft humerus when surgically fixed is known to go into non-union and one of the main reasons of this is implant failure. The causes of implant failure may lie in the fracture personality, faulty implant material or choice, dubious surgical technique & faulty mechanics of fixation.
Hitesh, Lal +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Numerical dynamic analysis of stiffened plates under blast loading
Latin American Journal of Solids and StructuresUsing the general purpose finite element package Abaqus, an investigation has been carried out to examine the dynamic response of steel stiffened plates subjected to uniform blast loading.
H.R. Tavakoli, F. Kiakojouri
doaj +1 more source
Translatory shock absorber for attitude sensors [PDF]
, 1976 A translatory shock absorber is provided for mounting an attitude sensor thereon for isolating a sensor from translatory vibrations. The translatory shock absorber includes a hollow block structure formed as one piece to form a parallelogram.
Kirby, C. A. +2 more
core +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source