Results 31 to 40 of about 5,864 (216)

Towards an Agent-Based Augmented Cloud

Journal of Telecommunications and Information Technology, 2012
In the paper an agent-based framework deployed in hybrid cluster and volunteer computing environment is presented. It utilizes two concepts proposed by the authors: Augmented Cloud and Agent Platform as a Service (AgPaaS). Both concepts are discussed in
Roman Dębski, Aleksander Byrski, Marek Kisiel-Dorohinicki   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Evaluating the Impact of Cloud Computing on SME Performance: A Systematic Review

Businesses
Small and medium-sized enterprises (SMEs) face substantial barriers in accessing reliable and cost-effective IT infrastructure, primarily due to economic constraints and limited technical resources.
Ayaphila Mkhize, Katleho D. Mokhothu, Mukhodeni Tshikhotho, Bonginkosi A. Thango   +3 more
doaj   +1 more source

A Systematic Mapping Study of MMOG Backend Architectures

Information, 2019
The advent of utility computing has revolutionized almost every sector of traditionalsoftware development. Especially commercial cloud computing services, pioneered by the likesof Amazon, Google and Microsoft, have provided an unprecedented opportunity ...
Nearchos Paspallis, Nicos Kasenides
doaj   +1 more source

A Novel Blockchain-as-a-Service (BaaS) Platform for Local 5G Operators

IEEE Open Journal of the Communications Society, 2021
5G is a promising technology that has the potential to support verticals and applications such as Industrial Internet of Things IoT (IIoT), smart cities, autonomous vehicles, remote surgeries, virtual and augmented realities, and so on.
Nisita Weerasinghe, Tharaka Hewa, Madhusanka Liyanage, Salil S. Kanhere, Mika Ylianttila   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

REDCap Platform-as-a-Service

, 2023
Background In early 2023, critical vulnerabilities were exposed in REDCap, posing a significant risk to the data stored by over 6000 partners worldwide. This incident highlighted a widespread issue: the lack of IT support for REDCap among smaller universities, medical research institutes, and non-profit organisations.
openaire   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source