Results 41 to 50 of about 86,152,617 (312)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Rollin’ Justin – Design considerations and realization of a mobile platform for a humanoid upper body

open access: yes, 2009
Research on humanoid robots for use in servicing tasks, e.g. fetching and delivery, attracts steadily more interest. With Rollin’ Justin a mobile robotic system and research platform is presented that allows the implementation and demonstration of ...
Hirzinger, Gerd   +44 more
core   +1 more source

Real-time HEP analysis with funcX, a high-performance platform for function as a service [PDF]

open access: yesEPJ Web of Conferences, 2020
We explore how the function as a service paradigm can be used to address the computing challenges in experimental high-energy physics at CERN. As a case study, we use funcX—a high-performance function as a service platform that enables intuitive ...
Woodard Anna Elizabeth   +9 more
doaj   +1 more source

A Service Packaging Platform for Delivering Services [PDF]

open access: yes2010 IEEE International Conference on Services Computing, 2010
For a service to be used in a commercial setting, certain service delivery functions such as monitoring, billing, authentication, etc need to be packaged with the service. Because of the growing number of available services and the diversity in their offerings, predefined service delivery functions like that offered by existing service brokers (e.g ...
Muhammad Adeel Talib   +4 more
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

CrowdPower: A Novel Crowdsensing-as-a-Service Platform for Real-Time Incident Reporting

open access: yesApplied Sciences, 2022
Crowdsensing using mobile phones is a novel addition to the Internet of Things applications suite. However, there are many challenges related to crowdsensing, including (1) the ability to manage a large number of mobile users with varying devices ...
Sujith Samuel Mathew   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Traffic Data Platform based on the Service Oriented Architecture (SOA) [PDF]

open access: yes, 2010
The DLR Traffic Data Platform (TDP) that is currently being developed by the German Aerospace Center (DLR) is an autonomous decentralised ITS system for distributed intelligent traffic data management and dissemination.
Brockfeld, Elmar   +5 more
core  

Do Google App Engine’s Runtimes Perform Homogeneously? An Empirical Investigation for Bonus Computing

open access: yesIEEE Access, 2019
Bonus computing is a new metacomputing form that takes advantage of free computing power from the public Cloud market. To maximize the value of free Cloud resources and facilitate dividing Bonus computing tasks, it would particularly be crucial to ...
Zheng Li, Xue Guo
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy