Results 41 to 50 of about 5,864 (216)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
IEEE Access, 2019 Bonus computing is a new metacomputing form that takes advantage of free computing power from the public Cloud market. To maximize the value of free Cloud resources and facilitate dividing Bonus computing tasks, it would particularly be crucial to ...
Zheng Li, Xue Guo
doaj +1 more source
Data Trusts as a Service: Providing a platform for multi‐party data sharing
International Journal of Information Management Data Insights, 2022 The major setback for data sharing is that data producers (i.e., subjects) are not able to determine how their data is being used/misused by data collectors (custodians).
Richard K. Lomotey +2 more
doaj +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
CrowdPower: A Novel Crowdsensing-as-a-Service Platform for Real-Time Incident Reporting
Applied Sciences, 2022 Crowdsensing using mobile phones is a novel addition to the Internet of Things applications suite. However, there are many challenges related to crowdsensing, including (1) the ability to manage a large number of mobile users with varying devices ...
Sujith Samuel Mathew +2 more
doaj +1 more source
Globus platform‐as‐a‐service for collaborative science applications [PDF]
Concurrency and Computation: Practice and Experience, 2014 SummaryGlobus, developed as software‐as‐a‐service for research data management, also provides APIs that constitute a flexible and powerful platform‐as‐a‐service to which developers can outsource data management activities such as transfer and sharing, as well as identity, profile, and group management. By providing these frequently important but always
Rachana Ananthakrishnan +3 more
openaire +3 more sources
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Architecture Design of Healthcare Software-as-a-Service Platform for Cloud-Based Clinical Decision Support Service [PDF]
Healthcare Informatics Research, 2015 ObjectivesTo design a cloud computing-based Healthcare Software-as-a-Service (SaaS) Platform (HSP) for delivering healthcare information services with low cost, high clinical value, and high usability.MethodsWe analyzed the architecture requirements of ...
Sungyoung Oh +10 more
doaj +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source