Results 91 to 100 of about 1,603,360 (267)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Development path of MaaS platforms in China

Journal of Highway and Transportation Research and Development
As urbanization progresses, a novel urban transportation paradigm known as Mobility as a Service (MaaS) has emerged, addressing the principles of environmentally friendly travel and sustainable transport development.
Wenkai Zhan, Zhendong Xie, Zhiguo Dong, Jiehan Yu, Ji Zhao   +4 more
doaj   +1 more source

Building an IoT Platform Based on Service Containerisation. [PDF]

Sensors (Basel), 2021
Antunes M, Santiago AR, Manso S, Regateiro D, Barraca JP, Gomes D, Aguiar RL.   +6 more
europepmc   +1 more source

Developing ecosystem service indicators: experiences and lessons learned from sub-global assessments and other initiatives [PDF]

, 2011
People depend upon ecosystems to supply a range of services necessary for their survival and well-being. Ecosystem service indicators are critical for knowing whether or not these essential services are being maintained and used in a sustainable manner ...
Armenteras, Dolors, Ash, Neville, Barano, Thomas, Beltrame, Coralie, Berg, Hakan, Bhagabati, Nirmal, Biala, Katarzyna, Birge, Traci, Bondarev, Alexander, Brown, Claire, Butchart, Stuart, Davidson, Nick, De Groot, Rudolf, Doswald, Natalie, Díaz, Sandra, Espaldon, Maria Victoria, Fuentes, Rodrigo, Garcia, Keisha, Ghate, Utkarsh, Girvan, Alexander, Goethals, Peter, Hadian, Oki, Höft, Robert, Koleff, Patricia, Kumar, Chetan, Larigauderie, Anne, Lasco, Rodel, Layke, Christian, Linstead, Conor, Luque Panadero, Victoria Eugenia, Mainka, Sue, Mapendembe, Abisha, Marcela, Mónica, Nybo, Signe, O'Farell, Patrick, Reyers, Belinda, Ricketts, Taylor, Ringold, Paul, Rodríguez Rodríguez, Davíd, Rosenthal, Amy, Sandlund, Odd Terje, Sarukhán, José, Scharlemann, Jorn, Schlatter, Christian, Simpson, Lucy, Stott, Andrew, Tierney, Megan, Tyrell, Tristan, UNEP-WCMC, -, Urquiza, Tania, Vackár, David, van Oudenhoven, Alexander, Viglizzo, Ernesto, Walpole, Matt, Watts, Jim, Williams, James, Yashina, Tatyana, Zandri, Edoardo   +57 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

MEDAS: an open-source platform as a service to help break the walls between medicine and informatics. [PDF]

Neural Comput Appl, 2022
Zhang L, Li J, Li P, Lu X, Gong M, Shen P, Zhu G, Shah SA, Bennamoun M, Qian K, Schuller BW.   +10 more
europepmc   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Genetics Adviser: a protocol for a mixed-methods randomised controlled trial evaluating a digital platform for genetics service delivery. [PDF]

BMJ Open, 2022
Shickh S, Hirjikaka D, Clausen M, Kodida R, Mighton C, Reble E, Sam J, Panchal S, Aronson M, Graham T, Armel SR, Glogowski E, Elser C, Eisen A, Carroll JC, Shuman C, Seto E, Baxter NN, Scheer A, Shastri-Estrada S, Feldman G, Thorpe KE, Schrader KA, Lerner-Ellis J, Kim RH, Faghfoury H, Bombard Y.   +26 more
europepmc   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source