Results 241 to 250 of about 334,214 (311)

The role of digital pharmaceutical governance in alleviating health inequality: a case study of the "Sanya Model" for centralized regional prescription review. [PDF]

Front Public Health
Jia X, Xie J, Chai F, Jiang H, Shi R.
europepmc   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Implementing UK Oncology Nursing Society-Informed Digital Symptom Triage With Episode-Based Review in Routine NHS Acute Oncology: Service Evaluation. [PDF]

JMIR Cancer
Mohamed Azhar MS, Ray R, Sharma S, Chauhan H, Robinson MR, Owoseni Y, Vijay A, Hussain S.   +7 more
europepmc   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

Financial Management Innovation in Hospital Groups: An Empirical Study of Ophthalmology Specialty Care Under Consolidation. [PDF]

Risk Manag Healthc Policy
Ye B, Pan X, Wu Z.
europepmc   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

TrainTracks - federated learning for reproducible research on sensitive medical data. [PDF]

BMC Med Inform Decis Mak
Elwes M, Jaberansary M, Tang FK, Aswendt M, Beyan O, Kutafina E.   +5 more
europepmc   +1 more source

Digital-Human Public Community Care Integration for Chronic Pain in Low-Income Older Adults in a 6-Week Living Lab Setting: Quasi-Experimental Feasibility Study. [PDF]

JMIR Aging
Song S, Hwang SY, Kim HY, Kim J.
europepmc   +1 more source

Management Model for the Evaluation of needs and Acquisition of Biomedical Equipment in Healthcare Institutions: Based on WHO Recommendations, and National Regulations. [PDF]

J Med Syst
Villamizar YLQ, Parra LMC, Arevalo FAC, Lozano YAL.   +3 more
europepmc   +1 more source