Results 61 to 70 of about 1,603,360 (267)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
CLOUD TECHNOLOGIES IN INNOVATIVE ACCOUNTING
Вестник Кемеровского государственного университета, 2013 Тhe research focuses on the innovations in accounting enabling to accumulate the resources of the organization more effectively, to reduce the costs associated with the acquisition of spare servers, etc.
R. T. Unshchikova, A. A. Ippolitowa
doaj
WIKI-WS AS A C2 NIWA WEB SERVICE MANAGEMENT PLATFORM
TASK Quarterly, 2015 The Wiki-WS platform was implemented within the C2 NIWA project for production purposes. Wiki-WS stands for developing, managing and maintaining web services.
MAREK DOWNAR
doaj +1 more source
Quality-aware model-driven service engineering [PDF]
, 2008 Service engineering and service-oriented architecture as an integration and platform technology is a recent approach to software systems integration.
Barrett, Ronan +3 more
core
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Templet Web: the use of volunteer computing approach in PaaS-style cloud
Open Engineering, 2018 This article presents the Templet Web cloud service. The service is designed for high-performance scientific computing automation. The use of high-performance technology is specifically required by new fields of computational science such as data mining,
Vostokin Sergei +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Crowdsourced Manufacturing in Industry 4.0: Implications and Prospects
SystemsCrowdsourced manufacturing, which has emerged as a pivotal paradigm in the era of Industry 4.0, redefines traditional production models by leveraging decentralized decision-making and collaborative networks.
Xuejian Gong +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source