Results 31 to 40 of about 3,431,200 (298)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Platform work and beyond

European Labour Law Journal, 2023
sponsorship: The special issue was made possible thanks to the Fund of Scientific Research (FWO) - Flanders and the Odysseus Grant (Ref. 179461/G0H8118N). In addition, Sara Huybrechts's contribution in particular was made possible by the (FWO) - Flanders' project funding (Ref. G049323N).
openaire   +2 more sources

Seconds-scale coherence in a tweezer-array optical clock [PDF]

, 2019
Optical clocks based on atoms and ions achieve exceptional precision and accuracy, with applications to relativistic geodesy, tests of relativity, and searches for dark matter.
Eckner, William J., Kaufman, Adam M., Norcia, Matthew A., Oelker, Eric, Ye, Jun, Young, Aaron W.   +5 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Remote Real-Time Collaboration Platform enabled by the Capture, Digitisation and Transfer of Human-Workpiece Interactions [PDF]

, 2015
In this highly globalised manufacturing ecosystem, product design and verification activities, production and inspection processes, and technical support services are spread across global supply chains and customer networks.
Advikolanu, Yohann, Burgess, Mark, Mcnally, Rob, Oyekan, John, Prabhu, Vinayak Ashok, Tiwari, Ashutosh   +5 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Agent-oriented approach to develop context-aware applications : a case study on communities of practice [PDF]

, 2005
This paper presents and discusses the use of an agent-oriented context-aware platform to support the interactions of the participating actors of communities of practice in the health care domain.
Bonino da Silva Santos, Luiz Olavo, Guizzardi-Silva Souza, Renata, Sinderen, Marten van   +2 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Towards developing a collaborative video platform for learning [PDF]

, 2012
The work presented in this paper outlines issues relating to the development of a collaborative video platform for learning. Student adoption of collaborative and video technology is increasing dramatically, becoming part of their everyday lives. The aim
Gurrin, Cathal, Tiernan, Peter
core