Results 61 to 70 of about 3,431,200 (298)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Venezuelan migrants in delivery platform work during the COVID-19 pandemic in Buenos Aires, Argentina: Between exploitability, precariousness, and daily resistance. [PDF]

Politics (Oxf), 2023
Lenis HFB.
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Coping with precarity during COVID-19: A study of platform work in Poland. [PDF]

Int Labour Rev, 2021
Muszyński K, Pulignano V, Domecka M, Mrozowicki A.   +3 more
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Working with collaboration platforms

, 2021
Companies increasingly use collaboration platforms that allow employees as well as customers or external employees to work and communicate in one digital space. In view of the wide range of possible uses and high potential for self-organisation, there are numerous challenges for the design of usage, such as the orchestration of different applications ...
Weissmann, Marliese, Hardwig, Thomas
openaire   +1 more source

Study of a modular extravehicular activity work platform [PDF]

Configurations for extravehicular activity work platforms for astronaut use in orbital ...

core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

How does a Network Platform Work for Participating Actors Towards Integrated Care Governance? A Case Study of a Dutch Hospital Region. [PDF]

Int J Integr Care, 2022
van der Woerd O, van Veen-Berkx E, van der Scheer W, Bal R.   +3 more
europepmc   +1 more source

Global Platform Work

, 2023
Digitale Freelance-Plattformen werben mit Flexibilität, Unabhängigkeit und dem Zugang zu einem weltweiten Arbeitsmarkt. Doch was bedeutet es, sich in diesem Umfeld zu organisieren und zu positionieren? »Global Platform Work« beleuchtet den Alltag von Grafikdesigner:innen, die von Indien aus über digitale Plattformen weltweit Aufträge erhalten.
openaire   +4 more sources