Results 71 to 80 of about 1,147,148 (263)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

An incomplete double movement: Spain’s legislative strategy for platform courier reclassification

International Labour Review
Digital labour platforms, which have long operated outside conventional employment frameworks, are now facing a regulatory drive. Spain seems to be at the forefront of this international effort, notably through a set of legislative initiatives – most ...
Tiago Alexandre VIEIRA
doaj   +2 more sources

Coping with precarity during COVID-19: A study of platform work in Poland. [PDF]

Int Labour Rev, 2021
Muszyński K, Pulignano V, Domecka M, Mrozowicki A.   +3 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Adopting a Universal Mandate on Platform Work: Balancing Contrasting Realities

Tilburg Law Review
The challenges that present-day globalization poses in setting international labour standards are not uncharted. The conflict between the role of global considerations, on the one hand, and national and local dimensions, on the other, is one well-known ...
Juliana Londoño Polo
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Non-standard employment in the Russian Federation: challenges and prospects for youth career development

Вестник университета
This article investigates the impact of non-standard (atypical) employment on the career trajectories of young people in the Russian Federation amid ongoing transformations in the labour market.
R. K. Dianov
doaj   +1 more source

How does a Network Platform Work for Participating Actors Towards Integrated Care Governance? A Case Study of a Dutch Hospital Region. [PDF]

Int J Integr Care, 2022
van der Woerd O, van Veen-Berkx E, van der Scheer W, Bal R.   +3 more
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Communication Inequality and the Technopolitical Structure of Platform Work: Aotearoa New Zealand Platform Workers During COVID-19

International Journal of Communication
Drawing on the culture-centered approach (CCA), we conducted 25 in-depth interviews with Aotearoa New Zealand rideshare and delivery drivers, demonstrating how the technopolitical structure of platform work intensified communication inequality, and ...
Leon A. Salter, Mohan J. Dutta
doaj