Results 61 to 70 of about 1,147,148 (263)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Italian Labour Law e-JournalThe aim of this research is to demonstrate that the centrality of Regulation (EU) 2016/679 (General Data Protection Regulation – GDPR), in its protective function of workers’ personal rights within the Member States of the European Union, is confirmed by
Anna Trojsi
doaj +1 more source
Partecipazione e Conflitto, 2023 Previous research on platform work has concentrated on questions of organization, technology and regulation, while the focus has been much less on institutions and mechanisms by which platform work challenges existing labor market and welfare state ...
Fabian Beckmann, Fabian Hoose
doaj
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
KözigazgatásTudományThe digital workplace is the result of a conceptual evolution and poses a number of challenges that affect labour law in many ways. Such challenges include teleworking and the home office, but several of these challenges may not seem to be of a (labour ...
Gábor Mélypataki +1 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The Specifics and Types of Platform Work
Abstract This chapter explores the nature and diversity of digital platform work, examining its conceptual foundations, emergence, and evolution across global and post-Soviet contexts. It identifies the main drivers of platform work, including technological advancement, labour market flexibility, and economic insecurity, highlighting ...
Remeikienė, Rita +1 more
openaire +2 more sources
Venezuelan migrants in delivery platform work during the COVID-19 pandemic in Buenos Aires, Argentina: Between exploitability, precariousness, and daily resistance. [PDF]
Politics (Oxf), 2023 Lenis HFB.
europepmc +1 more source