Results 101 to 110 of about 1,337,565 (255)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Use-Case-Driven Architectures for Data Platforms in Manufacturing
PlatformsSince the term “Industry 4.0” was coined in 2011, machine data retrieval, storage and processing has been one of the major drivers for process optimization and factory management.
Eike Permin +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Chilean Presidential Candidates Platforms 1989-2017
This is a collection of pdf documents with the campaign platforms (programas de gobierno) of presidential candidates in Chile, 1989 ...
Navia, Patricio, Verdugo, Sergio
core +1 more source
From Key Role to Core Infrastructure: Platforms as AI Enablers in Hospitality Management
PlatformsThe increasing complexity of managing maintenance activities across geographically dispersed hospitality facilities necessitates advanced digital solutions capable of effectively balancing operational costs and service quality.
Antonio Grieco +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
A MODEL OF ENDOGENOUS POLITICAL PARTY PLATFORMS [PDF]
We develop a model of endogenous party platform formation in a multidimensional policy space. Party platforms depend on the composition of the parties? primary electorate.
Andrei Gomberg +2 more
core
Cellular Communications Using Aerial Platforms
, 2001 This paper is devoted to the study of cellular communications using aerial platforms (APs). A set of key equations is derived that quantify the coverage area on the ground as a function of AP elevation, the operation of the adaptive multibeam antenna on ...
Steele, R., El-Jabu, B.
core +1 more source
Empirical Analysis of Social Media Influencers’ Effect on Consumer Purchase Intentions and Behavior
PlatformsSocial media influencers (SMIs) have become pivotal stakeholders in digital marketing. This study examines how SMIs influence consumer decision-making and investigates the role of trust in this process. Drawing on the theory of planned behavior (TPB), we
Godfried B. Adaba +2 more
doaj +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source