Results 81 to 90 of about 625,438 (268)

Designing Predictive Analytics Frameworks for Supply Chain Quality Management: A Machine Learning Approach to Defect Rate Optimization

Platforms
Efficient supply chain management (SCM) is essential for enterprises seeking to enhance operational efficiency, reduce costs, and mitigate risks while ensuring product quality and customer satisfaction. Addressing quality concerns within the supply chain
Zainab Nadhim Jawad, Balázs Villányi
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Qualitative Imbalance in Quantitative Growth: An Empirical Time Series Analysis of Korea’s Open Banking Platform

Platforms
Despite remarkable quantitative growth in Application Programming Interface (API) call volume, Korea’s Open Banking Platform faces a critical qualitative imbalance. This paper investigates this hidden challenge, revealing a significant divergence between
Gyongchan Chung
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Digital Transformation for Smart and Resilient Cities: Assessing Platform Maturity and ISO 37123 Compliance

Platforms
This paper explores the transformative potential of digital platforms in fostering resilient and intelligent urban environments, a critical need considering rapid urbanization and climate change.
Daiane Maria de Genaro Chiroli, Thallita Puzi Ferrassa, Leticia do Nascimento Idalgo, Marcela Marçal Alves Pinto Mick, João Luiz Kovaleski, Franciely Velozo Aragão, Sergio Mazurek Tebcherani, Fernanda Cavicchioli Zola   +7 more
doaj   +1 more source

PLATFORM CAPITALISM AND PLATFORMIZATION IN SCIENCE

, 2022
Oligopólios editoriais de publicações científicas têm reconfigurado seus modelos de negócios para atuarem como empresas de análise de dados, capturando e processando dados e metadados produzidos ao longo do processo de pesquisa e de sua comunicação. Frente ao avanço desses novos modelos de negócios, o trabalho busca apresentar conceitos de plataforma e
Pacanaro Trinca, Tatiane, Papi, Miguel Enrique Silveira, Albagli, Sarita   +2 more
openaire   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Industry 4.0 and Sustainability: Empirical Validation of Constructs of Industry Technology and Sustainable Development

Platforms
The study has as purpose to identify, analyze, and validate challenge constructs of Industry 4.0, which can affect the promotion of sustainability within the industry.
Lucas da Silva Melo, Reimison Moreira Fernandes, Denilson Ricardo de Lucena Nunes, Renata Melo e Silva de Oliveira, Jonhatan Magno Norte da Silva, Lucas Veiga Avila, Vitor William Batista Martins   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Construction of a Socialized Service Platform and System for “Internet + Agriculture” in China

Platforms
The mismatch between supply and demand and inefficient supply in China’s agricultural product market is quite severe, making agricultural supply-side structural reform an important topic and task for rural economic work in China.
Run Tang, Qirui Liu, Ya Ou
doaj   +1 more source