Results 81 to 90 of about 630,006 (269)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Qualitative Imbalance in Quantitative Growth: An Empirical Time Series Analysis of Korea’s Open Banking Platform

Platforms
Despite remarkable quantitative growth in Application Programming Interface (API) call volume, Korea’s Open Banking Platform faces a critical qualitative imbalance. This paper investigates this hidden challenge, revealing a significant divergence between
Gyongchan Chung
doaj   +1 more source

Platforms as regulators

Journal of Antitrust Enforcement, 2020
Abstract The proposition that certain digital platforms act as ‘regulators’ within their own business models is a key pillar of the European Commission report on Competition Policy for the Digital Era, and the basis upon which its authors build a wide-ranging duty for dominant platforms to secure competition that is ‘fair, unbiased and ...
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Digital Transformation for Smart and Resilient Cities: Assessing Platform Maturity and ISO 37123 Compliance

Platforms
This paper explores the transformative potential of digital platforms in fostering resilient and intelligent urban environments, a critical need considering rapid urbanization and climate change.
Daiane Maria de Genaro Chiroli, Thallita Puzi Ferrassa, Leticia do Nascimento Idalgo, Marcela Marçal Alves Pinto Mick, João Luiz Kovaleski, Franciely Velozo Aragão, Sergio Mazurek Tebcherani, Fernanda Cavicchioli Zola   +7 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Industry 4.0 and Sustainability: Empirical Validation of Constructs of Industry Technology and Sustainable Development

Platforms
The study has as purpose to identify, analyze, and validate challenge constructs of Industry 4.0, which can affect the promotion of sustainability within the industry.
Lucas da Silva Melo, Reimison Moreira Fernandes, Denilson Ricardo de Lucena Nunes, Renata Melo e Silva de Oliveira, Jonhatan Magno Norte da Silva, Lucas Veiga Avila, Vitor William Batista Martins   +6 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The Construction of a Socialized Service Platform and System for “Internet + Agriculture” in China

Platforms
The mismatch between supply and demand and inefficient supply in China’s agricultural product market is quite severe, making agricultural supply-side structural reform an important topic and task for rural economic work in China.
Run Tang, Qirui Liu, Ya Ou
doaj   +1 more source

eIF2α phosphorylation: A hallmark of immunogenic cell death

OncoImmunology, 2018
Immunogenic cell death (ICD) induced by anticancer chemotherapeutics is usually preceded by premortem stress affecting the endoplasmic reticulum (ER). This ER stress does not reflect a canonical unfolded protein response (UPR) but rather manifests solely
Lucillia Bezu, Allan Sauvat, Juliette Humeau, Marion Leduc, Oliver Kepp, Guido Kroemer   +5 more
doaj   +1 more source