Results 61 to 70 of about 1,337,565 (255)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Online Toxicity: Birthed from Polarization, Raised by Platforms
PlatformsOnline toxicity has become a defining feature of contemporary digital discourse, permeating all forms of online discussion, from news websites and discussion forums to social media platforms. While prior research has examined toxic behaviour across these
Iliana Giannouli +1 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
PlatformsArtificial intelligence has become increasingly embedded in digital marketing, reshaping how firms collect consumer data, personalize content, automate persuasion, and evaluate campaign performance. While these developments offer clear strategic benefits,
Alexios Kaponis, Manolis Maragoudakis
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Privacy and Manipulation in the Platform Economy: An EU Framework for Regulating Dark Patterns
PlatformsTechnological advancements have transformed the ways in which individuals interact with digital platforms, giving rise to data-driven ecosystems in which interface design plays a central role. Within these environments, dark patterns and manipulative and
Panagiotis Kitsos, Paraskevi Pappa
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
PlatformsOn-site search has become a critical component of e-commerce platforms, shaping product discovery, navigation, and purchasing decisions. While prior research has extensively examined search algorithms and information retrieval, less attention has been ...
Konstantinos Papanikolaou +2 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
TWO-SIDED PLATFORMS WITH ENDOGENOUS QUALITY DIFFERENTIATION [PDF]
In this paper we construct a simple model of platform price competition with two main novel features. First, platforms endogenously decide the quality of their `access service' and second, each group exhibits preferences not only about the number of ...
María Fernanda Viecens
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