α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
The Social Responsibility of Young Professionals Working with Information Systems and Technologies
PlatformsResearch purpose—Economy digital transformation has had a strong impact on several areas, such as employment, economic organization modus operandi, or the digital modernization of economic agents.
Pedro Anunciação +2 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Relationship Between Visual Marketing Elements and Consumer Satisfaction
PlatformsWith the rapid expansion of online shopping, website design has become a critical factor influencing user experience and consumer satisfaction. This study examines the relationship between visual marketing elements embedded in e-commerce web page design ...
Ruiyang Tang, Xuanzhen Cui, Yuki Inoue
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Voices in Videos: How YouTube Is Used in #BLM and #StopAAPIHate Movements
PlatformsVideo-sharing platforms have significantly influenced social justice movements by creating unprecedented opportunities for mobilization and support.
Aanandita Bali, Shuo Niu
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The Attitude-Behavior Gap in Technology Adoption: A Consumer Behavior Perspective on HRIS Use
PlatformsHuman Resource Information Systems (HRIS) are often introduced as platforms expected to deliver strategic value through workforce analytics, decision support, and alignment with organizational goals.
Fadi Sofi, Anas Al-Fattal
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Systematic Assessment of Modeling Techniques to Support the Conceptual Design of Digital Ecosystems
PlatformsDigital ecosystems are sociotechnical systems that connect various business actors via digital platforms. While they drive digital transformation across domains, their conceptual design remains challenging due to the need to address legal, technical, and
Karina Villela +2 more
doaj +1 more source