Results 41 to 50 of about 1,337,565 (255)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Platformization in Tourism: Typology of Business Models, Evolution of Market Concentration and European Regulation Responses

Platforms
The paper serves to discuss the evolution of platform business models in tourism, the dynamics of market concentration, and regulatory interventions. We present the historical timeline of digitalization in tourism distribution models, starting from the ...
Maja Turnšek, Vladimir Radivojević
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Platforms as Proximity Enablers for Regional Development

Platforms
This study offers a theoretical contribution exploring the interplay between platforms, proximity, and regional development and highlighting platforms’ crucial role in transforming routines and enhancing regional capabilities.
Anastasia Panori
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Resource allocation algorithms for virtualized service hosting platforms [PDF]

, 2010
Commodity clusters are used routinely for deploying service hosting platforms. Due to hardware and operation costs, clusters need to be shared among multiple services.
Schanzenbach, David, Vivien, F, Schanzenbach, D, Henri Casanova, Casanova, Henri, Mark Stillwell, Stillwell, Mark Lee, Frédéric Vivien, Vivien, Frederic, David Schanzenbach, Stillwell, Mark, Stillwell, M, Casanova, H   +12 more
core   +1 more source

Servicing polar platforms using electric propulsion [PDF]

, 1992
The future of space development has been examined in the context of the infrastructure necessary support it. It is concluded that the selection of propulsion systems for in-orbit transportation requires the development of general computer codes capable
Welch, C. S.
core   +4 more sources

A Scalable Framework for Real-Time Network Security Traffic Analysis and Attack Detection Using Machine and Deep Learning

Platforms
This paper presents an advanced framework for real-time monitoring and analysis of network traffic and endpoint security in large-scale enterprises by addressing the increasing complexity and frequency of cyber-attacks.
Zineb Maasaoui, Mheni Merzouki, Abdella Battou, Ahmed Lbath   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Role of the Platform Economy in Transforming Automotive Suppliers: A Case Study of the Northern Black Forest

Platforms
The European automotive industry, particularly in Germany, faces a significant crisis, heavily impacting suppliers reliant on OEMs. To enhance resilience, participation in the platform economy has been proposed as a solution.
Bernhard Kölmel, Rebecca Bulander, Lukas Waidelich, Luc Schmerber, Luca Fischer, Abderrahim Moussaref   +5 more
doaj   +1 more source