Results 71 to 80 of about 625,438 (268)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
PlatformsThis article examines how platform-mediated crisis policy shaped inclusion and exclusion outcomes for small, medium, and micro enterprises (SMMEs) in the Western Cape during COVID-19.
Carin Loubser-Strydom, Klavdij Logožar
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Use-Case-Driven Architectures for Data Platforms in Manufacturing
PlatformsSince the term “Industry 4.0” was coined in 2011, machine data retrieval, storage and processing has been one of the major drivers for process optimization and factory management.
Eike Permin +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
From Key Role to Core Infrastructure: Platforms as AI Enablers in Hospitality Management
PlatformsThe increasing complexity of managing maintenance activities across geographically dispersed hospitality facilities necessitates advanced digital solutions capable of effectively balancing operational costs and service quality.
Antonio Grieco +2 more
doaj +1 more source
Journal of Antitrust Enforcement, 2020 Abstract The proposition that certain digital platforms act as ‘regulators’ within their own business models is a key pillar of the European Commission report on Competition Policy for the Digital Era, and the basis upon which its authors build a wide-ranging duty for dominant platforms to secure competition that is ‘fair, unbiased and ...
openaire +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Empirical Analysis of Social Media Influencers’ Effect on Consumer Purchase Intentions and Behavior
PlatformsSocial media influencers (SMIs) have become pivotal stakeholders in digital marketing. This study examines how SMIs influence consumer decision-making and investigates the role of trust in this process. Drawing on the theory of planned behavior (TPB), we
Godfried B. Adaba +2 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source