Results 71 to 80 of about 630,006 (269)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Voices in Videos: How YouTube Is Used in #BLM and #StopAAPIHate Movements
PlatformsVideo-sharing platforms have significantly influenced social justice movements by creating unprecedented opportunities for mobilization and support.
Aanandita Bali, Shuo Niu
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Use-Case-Driven Architectures for Data Platforms in Manufacturing
PlatformsSince the term “Industry 4.0” was coined in 2011, machine data retrieval, storage and processing has been one of the major drivers for process optimization and factory management.
Eike Permin +2 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
From Key Role to Core Infrastructure: Platforms as AI Enablers in Hospitality Management
PlatformsThe increasing complexity of managing maintenance activities across geographically dispersed hospitality facilities necessitates advanced digital solutions capable of effectively balancing operational costs and service quality.
Antonio Grieco +2 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Empirical Analysis of Social Media Influencers’ Effect on Consumer Purchase Intentions and Behavior
PlatformsSocial media influencers (SMIs) have become pivotal stakeholders in digital marketing. This study examines how SMIs influence consumer decision-making and investigates the role of trust in this process. Drawing on the theory of planned behavior (TPB), we
Godfried B. Adaba +2 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
PlatformsEfficient supply chain management (SCM) is essential for enterprises seeking to enhance operational efficiency, reduce costs, and mitigate risks while ensuring product quality and customer satisfaction. Addressing quality concerns within the supply chain
Zainab Nadhim Jawad, Balázs Villányi
doaj +1 more source