Results 81 to 90 of about 162,503 (302)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Late metal-silicate separation on the IAB parent asteroid: Constraints from combined W and Pt isotopes and thermal modelling

, 2018
The short-lived $^{182}$Hf-$^{182}$W decay system is a powerful chronometer for constraining the timing of metal-silicate separation and core formation in planetesimals and planets. Neutron capture effects on W isotopes, however, significantly hamper the
Cook, David L., Ek, Mattias, Golabek, Gregor J., Hunt, Alison C., Lichtenberg, Tim, Reger, Philip M., Schönbächler, Maria   +6 more
core   +1 more source

Antimony-doped graphene nanoplatelets [PDF]

, 2015
Heteroatom doping into the graphitic frameworks have been intensively studied for the development of metal-free electrocatalysts. However, the choice of heteroatoms is limited to non-metallic elements and heteroatom-doped graphitic materials do not ...
A Fasolino, A Ramelan, AA Balandin, AB Stambouli, C Zhang, C-M Gong, D Geng, H Liu, I-Y Jeon, I-Y Jeon, I-Y Jeon, I-Y Jeon, J Chen, J Greeley, J Liang, JK Nørskov, JP Collman, JW Cogswell, K Schoots, KN Kudin, KP Gong, KS Kim, L Qu, MD Stoller, MP Seah, R Bashyam, R Liu, RC Saxena, S Bae, S Jacobsson, S Wang, S Yang, T Krishnakumar, T Xing, T Yu, TO Wehling, W Sheng, WE Swartz Jr, WS Hummers Jr, X Sun, X Wang, Y Bing, Y Liang, YD Wang, Z Jin, Z Yang, Z-H Sheng, ZQ Li   +47 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Discovery of Tantalum, Rhenium, Osmium, and Iridium Isotopes [PDF]

, 2011
Currently, thirty-eight tantalum, thirty-eight rhenium, thirty-nine osmium, and thirty-eight iridium, isotopes have been observed and the discovery of these isotopes is discussed here.
Abou-Leila, Akhmadzhanov, Alkhomashi, Amaldi, Amaldi, Arblaster, Arblaster, Arlt, Arlt, Aston, Aston, Aston, Aston, Aten, Aten, Audi, Baranov, Baro, Bedrosyan, Belyaev, Belyaev, Belyaev, Benlliure, Berlovich, Berlovich, Berlovich, Bernas, Bianco, Bishop, Blachot, Blichert-Toft, Borggreen, Bosch-Wicke, Bothe, Bruchertseifer, Burde, Butement, Butement, Butement, Butement, Butement, Cabot, Cabot, Chang, Christian, Chu, Crasemann, Davids, Della Negra, Diamond, Diamond, Eichler, Fajans, Faler, Fermi, Flegenheimer, Fomin, Foster, Gallagher, Ginepro, Goodman, Goriely, Grigorev, Haldar, Harmatz, Harmatz, Haustein, Hofmann, Hofmann, Hofmann, Hofstetter, Hollander, Hughes, Jansen, Joss, Kettunen, Kistiakowsky Fischer, Kurtchatov, Kurtschatow, Lavrukhina, Leber, Lederer, Liang, Liang, Lindner, Livingood, M. Thoennessen, Mahmud, McMillan, Meissner, Nadjakov, Nadzhakov, Nier, Oldenberg, Page, Page, Poe, Pool, R. Robinson, Rezanka, Runte, Schrewe, Schrewe, Seaborg, Seaborg, Siivola, Sinma, Smith, Steer, Steer, Sterna, Stover, Strominger, Surkov, Szalay, Szymanski, Szymanski, Thoennessen, Toth, Toth, Turner, Uusitalo, Valiente-Dobón, Venkatesachar, Vonach, Wilkinson, Wilkinson, Wilkinson, Xu, Zhao, Zhou, Zingg   +131 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Asteroid 1986 DA: Radar evidence for a metallic composition [PDF]

Radar observations of the near-Earth asteroid 1986 DA were carried out at the Arecibo Observatory in April 1986, two months after its discovery. Radar results are consistent with the hypothesis that 1986 HA is a piece of NiFe metal derived from the ...
Campbell, D. B., Chandler, J. F., Hine, A. A., Hudson, R. S., Ostro, Steven J., Rosema, K. D., Shapiro, Irwin I.   +6 more
core   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source