Results 111 to 120 of about 228,477 (296)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Playing Gebeta in Preschool: Informal Pathways to Early Numeracy Through Directionality and Bundling
Education SciencesPreschool children develop essential mathematical concepts through play, yet little is known about how traditional board games can support this process. This small-scale microgenetic case study investigates how children unfamiliar with the Ethiopian game
Oliver Thiel
doaj +1 more source
, 2014 My degree project consists of several parts: a theorethical essay, sketches, modells, photos, experiments and an installation showed at Konstfack Spring Exhibition 2014. Departing from the infamous Fredric Jameson quote ”It’s easier to imagine the end of the world than the end of capitalism” I have investigated the relationship between play ...
openaire +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Sport rules, sport moral values and fair play
, 2011 In this paper the author considers the rules of sports (constitutive and sportsmanship rules), moral values of sports (justice, honesty, responsibility, benefi cence) and fair play. Constitutive rules are the rules which determine the essence of the game
Željko Kaluđerović +1 more
core
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Cover -- Title Page -- Copyright -- Contents -- A Speedy Sport -- Growing the Game -- International Play -- The Rules of the Game -- Lacrosse Gear -- What's Different?
Rogers, Kate.
core
The Rules We Break: Lessons in Play, Thinking and Design
, 2023 Review of: ZIMMERMAN, E.: The Rules We Break: Lessons in Play, Thinking And Design. New York, NY : Princeton Architectural Press, 2022. 208 p.
Kovalčík, Juraj
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source