Results 101 to 110 of about 228,477 (296)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Computers and play in early childhood: Affordances and limitations
, 2010 The widespread proliferation of computer games for children as young as six months of age, merits a reexamination of their manner of use and a review of their facility to provide opportunities for developmental play.
Verenikina, I. +3 more
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The Ecological and Civil Mainsprings of Property: An Experimental Economic History of Whalers’ Rules of Capture [PDF]
This paper uses a laboratory experiment to probe the proposition that property emerges anarchically out of social custom. We test the hypothesis that whalers in the 18th and 19th century developed rules of conduct that minimized the sum of the ...
Karl Schurter +3 more
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Official Crazy 8's add-a-play game rules [PDF]
, 2011 This document presents the game rules and guidelines for the South Carolina instant ticket game “Crazy 8's add-a-play.
South Carolina Education Lottery
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Decoding preschool children’s emerged rules during pretend play activities
, 2012 Είναι πραγματικά ιδιαίτερα ενδιαφέρον, ότι τα παιδιά κατά τη διάρκεια των αυθόρμητων δραστηριοτήτων παιχνιδιού, παρόλο που δεν είναι υποχρεωμένα, με ένα φυσικό τρόπο επιλέγουν να θεσπίσουν και να ακολουθήσουν κανόνες στις δραστηριότητες παιχνιδιού που ...
Κακανά (Domna-Mika Kakana), Δόμνα–Μίκα +1 more
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Official cash count up add-a-play game rules [PDF]
, 2010 This document presents the game rules and guidelines for the South Carolina instant ticket game “Cash count up add-a-play.
South Carolina Education Lottery
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