Results 81 to 90 of about 228,477 (296)
, 2022 A provocative study that reconsiders our notion of play—and how its deceptively wholesome image has harmed and erased people of color.Contemporary theorists present play as something wholly constructive and positive.
Trammell, Aaron
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
My own space. The study of our childhood playground and the rules that self-regulated the play [PDF]
Journal of Urban and Landscape Planning, 2018 I wanted this exercise of imagination to make a brief analysis of the playground and the way we managed to organize it during childhood. Our space is subjectively centered. It is organized around us and our needs. Most of the time this space is organized
Radu-Mihai Sansebes
doaj
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Play in Chinese kindergartens : teachers' perceptions and practices [PDF]
Play is widely recognized as a natural ability and fundamental right of children. In educational settings, the idea of integrating play into early childhood education to promote children’s learning and development has been continually advocated by ...
Yang, Yanjuan
core
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Modelling the effect of learning and evolving rules on the use of common-pool resources [PDF]
The extend to which common-pool resources are used and managed sustainably depends highly on incentives. Incentives influence the behaviour of individuals with respect to natural resource management and are determined by institutional arrangements ...
Alexander Smajgl
core
Not Playing by the Rules: Exploratory Play, Rational Action, and Efficient Search
Open Mind, 2023 Junyi Chu, Laura E. Schulz
doaj +1 more source