Results 191 to 200 of about 195,998 (250)

Whistleblower: the front line and critical facilitator for injury prevention policy? [PDF]

Inj Prev
West SW, Heming E, Klassen C, Lewis K, Emery CA.   +4 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

The relationship between structural campus climate and non-suicidal self-injury among middle school students: the chain-mediated roles of physical exercise and school bullying. [PDF]

Front Psychol
Zhou Y.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

FunEball: an emerging inclusive sport to enhance engagement and fundamental movement skills in physical education. [PDF]

Front Psychol
Liu Q, Dong Q, Fang Q, Oh E, Jia M, Yang D.   +5 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Persistent representation of a prior schema in the orbitofrontal cortex facilitates learning of a conflicting schema. [PDF]

Nat Commun
Maor I, Atwell J, Ascher I, Zhao Y, Takahashi YK, Hart E, Pereira F, Schoenbaum G.   +7 more
europepmc   +1 more source

The Role of Plasticity in Replay: Stability Through Anti-Hebbian Rules. [PDF]

Hippocampus
Baron L, Diba K, Amarasingham A.
europepmc   +1 more source

GDROM v2: An Inventory of Operation Variables Time Series and Rules for 2,017 Large Reservoirs across the CONUS. [PDF]

Sci Data
Zheng Z, Cai X, Zhang L, Li J, Chen Y.
europepmc   +1 more source