Results 101 to 110 of about 1,086,832 (253)

The Effect of Equine-Assisted Therapy and Play Therapy on Gross Perceptual-Motor Performance and Related Biomechanical Parameters in Adolescents with Autism [PDF]

open access: yesBiyumikānīk-i varzishī
Objective Autism Spectrum Disorder (ASD) is a neurodevelopmental condition marked by social communication difficulties and repetitive behaviors, often accompanied by motor skill impairments.
zahra Ghadimi kalateh   +4 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Effectiveness of mandala coloring and playing with Lego on children’s preoperative anxiety: A Randomized Clinical Trial [PDF]

open access: yesJournal of Research Development in Nursing and Midwifery
Background: Mandala Coloring and Playing are distraction strategies to reduce the anxiety level in children. However, their effects are inconsistent and have received little attention for the management and prevention of anxiety in hospitalized children.
Azam Shirinabadi Farahani   +5 more
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The Effectiveness of Filial Therapy on Fear of Coronavirus in Children

open access: yesدانش و پژوهش در روان‌شناسی کاربردی
The purpose of current study was to investigate the effectiveness of filial therapy on fear of coronavirus in children. The present study was a quasi-experimental study with a pretest, posttest, and control group.
zahra ahmadian   +2 more
doaj  

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