Results 81 to 90 of about 1,086,832 (253)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Cognitive-Behavioral Play Therapy and COVID-19 Pandemic Trauma in Preschool Children. [PDF]

Cureus, 2023
Raudenska J, Gumančík J, Raudenský M, Pasqualucci A, Moka E, Varrassi G, Paladini A, Javurkova A.   +7 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Integration of play therapy through architectural design strategies for children with physical disabilities

Al-Qadisiyah Journal for Engineering Science
Physical disability makes it hard for a person to take a walk, run, watch closely, and do other usual life tasks. Similarly, being mischievous is something that is expected to be part of a child’s nature.
Yasser Arab, Aimi Zahirah Zulkarnain, Maryam Saeed   +2 more
doaj   +1 more source

Play therapy and storytelling intervention on children's social skills with attention deficit-hyperactivity disorder. [PDF]

J Educ Health Promot, 2023
Karbasi Amel A, Rahnamaei H, Hashemi Z.
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Effects of psychological interventions based on play therapy on clinical symptoms of restlessness in preschool children

مجله علوم روانشناختی, 2015
Currently family based Therapies have been considered one of the important approaches to prevent children from psychological pathologies these approaches have been acknowledged by parents and professionals as well.
Saee'd Rahimi, Bagher Ghobari Bonab, GholamAli Afrooz, Salar Faramarzi   +3 more
doaj  

Play therapy in children with autism: Its role, implications, and limitations. [PDF]

World J Clin Pediatr, 2023
Elbeltagi R, Al-Beltagi M, Saeed NK, Alhawamdeh R.   +3 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source