Results 111 to 120 of about 2,095,235 (276)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Effect of group sand play therapy on psychopathologies of adolescents with delinquent behaviors. [PDF]
Medicine (Baltimore), 2023 Lee S, Kwak HJ, Ahn UK, Kim KM, Lim MH.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Cognitive-Behavioral Play Therapy and COVID-19 Pandemic Trauma in Preschool Children. [PDF]
Cureus, 2023 Raudenska J +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
مجله علوم روانشناختی, 2015 Currently family based Therapies have been considered one of the important approaches to prevent children from psychological pathologies these approaches have been acknowledged by parents and professionals as well.
Saee'd Rahimi +3 more
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Play therapy and storytelling intervention on children's social skills with attention deficit-hyperactivity disorder. [PDF]
J Educ Health Promot, 2023 Karbasi Amel A, Rahnamaei H, Hashemi Z.
europepmc +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Taḥqīqāt-i ̒Ulūm-i Raftārī, 2022 Aim and Background: Cancer and its special treatments and hospitalization in the cold environment of the hospital have deep psychological effects on children. The present study was conducted with the aim of determining the effectiveness of the cognitive
Aida Farsham +4 more
doaj